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Novel biophysical methods Section edited by Werner Kremer and Alberto Diaspro

This section incorporates all aspects of novel advanced biophysical methods including fluorescence, NMR, microscopy, spectroscopy, X-ray, single molecule biophysics, nanoscale biophysics, high pressure biophysics and related biophysical techniques.

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1.

Research article   Open Access Highly Accessed

Hierarchical super-structure identified by polarized light microscopy, electron microscopy and nanoindentation: Implications for the limits of biological control over the growth mode of abalone sea shells

Andreas S Schneider, Birgit Heiland, Nicolas J Peter, Christina Guth, Eduard Arzt, Ingrid M Weiss BMC Biophysics 2012, 5:19 (12 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The hierarchical super-structure of abalone mollusc shells can be revealed by conventional light microscopy methods, opening the potential to study shell growth mechanisms in vivo at high resolution.

2.

Methodology article   Open Access

A Bayesian method for inferring quantitative information from FRET data

Catherine A Lichten, Peter S Swain BMC Biophysics 2011, 4:10 (9 May 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A new Bayesian algorithm is available for extracting quantitative information on molecular interactions from FRET (Forster resonance energy transfer) data which yields both an estimate of the dissociation constant and the uncertainty associated with that estimate.

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