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Computational and theoretical biophysics Section edited by Rebecca Wade and Dimitrios Morikis

This section incorporates all aspects of computational and theoretical biophysics including: theory, modeling, simulation and nanotechnology.

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1.

Research article   Open Access

Self-consistent field theory for the interactions between keratin intermediate filaments

Anna Akinshina, Etienne Jambon-Puillet, Patrick B Warren, Massimo G Noro BMC Biophysics 2013, 6:12 (5 September 2013)

Abstract | Full text | PDF | PubMed

2.

Methodology article   Open Access

Time-resolved force distribution analysis

Bogdan I Costescu, Frauke Gräter BMC Biophysics 2013, 6:5 (1 May 2013)

Abstract | Full text | PDF | ePUB |  Editor’s summary

Time-resolved force distribution analysis is a new method to monitor the fluctuations of internal forces in complex macromolecular structures, and is an alternative approach to coordinate-based methods for analyzing structural transitions.

3.

Research article   Open Access Highly Accessed

Stochastic dynamics of virus capsid formation: direct versus hierarchical self-assembly

Johanna E Baschek, Heinrich C R Klein, Ulrich S Schwarz BMC Biophysics 2012, 5:22 (17 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Computational modeling of the way that viruses are able to self-assemble their protein capsid coats suggests that for complex viruses with more stable bonds, a piecemeal hierarchical assembly process is most likely.

4.

Commentary   Open Access Highly Accessed

Intracellular chemical gradients: morphing principle in bacteria

Robert G Endres BMC Biophysics 2012, 5:18 (7 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Robert Endres discusses a new study in BMC Biophysics that supports the emerging view that intracellular chemical gradients can exist in bacterial cells, and how these may limit in vitro analyses.

5.

Research article   Open Access Highly Accessed

Clustering of HIV-1 Subtypes Based on gp120 V3 Loop electrostatic properties

Aliana López de Victoria, Chris A Kieslich, Apostolos K Rizos, Elias Krambovitis, Dimitrios Morikis BMC Biophysics 2012, 5:3 (7 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The spatial distributions of electrostatic potentials and charges in the V3 loop of HIV-1 protein gp120 may be responsible for both long- and short-range interactions with co-receptors, ultimately affecting viral entry into cells

6.

Research article   Open Access

Using default constraints of the spindle assembly checkpoint to estimate the associated chemical rates

Khanh Dao Duc, David Holcman BMC Biophysics 2012, 5:1 (19 January 2012)

Abstract | Full text | PDF | PubMed

7.

Research article   Open Access

Brownian dynamics simulation of analytical ultracentrifugation experiments

AI Díez, A Ortega, J Garcia de la Tore BMC Biophysics 2011, 4:6 (2 March 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Using Brownian dynamics to simulate the trajectories of the particles could lead to improved and efficient predictions of time-dependent concentration profiles during analytical ultracentrifugation experiments.

8.

Research article   Open Access

A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction

Jorge L Barreda, Huan-Xiang Zhou BMC Biophysics 2011, 4:5 (2 March 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

An analytical solution to modeling the diffusion and reaction of acetylcholine in a neuromuscular junction and the binding of Ca2+ in a dyadic cleft provides a unique benchmark for testing numerical modeling methods.

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