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	26. 80 Accesses	Research article Spindles and active vortices in a model of confined filament-motor mixtures David A Head, WJ Briels, Gerhard Gompper BMC Biophysics 2011, 4:18 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A discrete filament-motor protein model of subcellular microtubule self-assembly in fission yeast spontaneously generates a number of steady states, including spindles, nematics, and asters, highlighting potential mechanisms for self-organisation in filaments
	27. 78 Accesses	Methodology article A Bayesian method for inferring quantitative information from FRET data Catherine A Lichten, Peter S Swain BMC Biophysics 2011, 4:10 (9 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new Bayesian algorithm is available for extracting quantitative information on molecular interactions from FRET (Forster resonance energy transfer) data which yields both an estimate of the dissociation constant and the uncertainty associated with that estimate.
	28. 78 Accesses	Research article Arbitrary protein−protein docking targets biologically relevant interfaces Juliette Martin, Richard Lavery BMC Biophysics 2012, 5:7 (6 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Docking of target proteins against an arbitrary set of partners generally leads to non-random localization of interaction interfaces as the false complexes favor residues from true interaction sites, allowing prediction of biologically relevant protein interfaces
	29. 76 Accesses	Research article Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations Haina Qin, Liangzhong Lim, Jianxing Song BMC Biophysics 2012, 5:2 (25 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Structural determination of the EphA4 ligand binding domain provides the first experimental and computational evidence that intrinsic dynamics are most likely to be responsible for the observed high conformational diversity that mediates binding affinity and specificity.
	30. 74 Accesses	Research article Sensing the Heat Stress by Mammalian Cells Jordan Cates, Garrett C Graham, Natalie Omattage, Elizabeth Pavesich, Ian Setliff, Jack Shaw, Caitlin Smith, Ovidiu Lipan BMC Biophysics 2011, 4:16 (11 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new system-level mathematical approach is proposed to model the heat-shock response network in mammalian cells and the key heat-shock transcription factor-1 (HSF) which is transiently activated by elevated temperatures.
	31. 72 Accesses	Research article Wavelet-based protocols for ion channel electrophysiology Armin Kargol BMC Biophysics 2013, 6:3 (14 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	32. 68 Accesses	Research article Pulling chromatin apart: Unstacking or Unwrapping? Jean Marc Victor, Jordanka Zlatanova, Maria Barbi, Julien Mozziconacci BMC Biophysics 2012, 5:21 (27 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A zig-zag model of chromatin fiber morphology is able to quantitatively explain the mechanical properties of chromatin under external stress, and provides an alternative explanation to the widespread solenoid model interpretation.
	33. 68 Accesses	Research article Thermotropic phase behavior and headgroup interactions of the nonbilayer lipids phosphatidylethanolamine and monogalactosyldiacylglycerol in the dry state Antoaneta V Popova, Dirk K Hincha BMC Biophysics 2011, 4:11 (10 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The thermotropic phase behavior and molecular interactions of the two biologically important non-bilayer lipids, egg phosphatidylethanolamine (EPE) and monogalactosyldiacylglycerol (MGDG) have been comprehensively characterized by Fourier-transform Infrared spectroscopy and Differential Scanning Calorimetry.
	34. 68 Accesses	Research article Membrane microdomains emergence through non-homogeneous diffusion Hédi A Soula, Antoine Coulon, Guillaume Beslon BMC Biophysics 2012, 5:6 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Non-homogeneous diffusion in cell membranes leads to the formation of protein/ lipid enriched microdomains in a model of membrane dynamics, with domains of high viscosity tending to gather a statistically larger proportion of diffusive particles
	35. 66 Accesses	Research article Lipid recognition propensities of amino acids in membrane proteins from atomic resolution data Mizuki Morita, AVSK Katta, Shandar Ahmad, Takaharu Mori, Yuji Sugita, Kenji Mizuguchi BMC Biophysics 2011, 4:21 (14 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Tightly-bound lipid molecules and lipids in the annular shell interact with membrane proteins in a similar manner, largely explained by general lipophilicity, that suggests a common pattern of lipid tail-amino acid interactions
	36. 65 Accesses	Research article Brownian dynamics simulation of analytical ultracentrifugation experiments AI Díez, A Ortega, J Garcia de la Tore BMC Biophysics 2011, 4:6 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Using Brownian dynamics to simulate the trajectories of the particles could lead to improved and efficient predictions of time-dependent concentration profiles during analytical ultracentrifugation experiments.
	37. 64 Accesses	Research article Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells Erik S Welf, Ulhas P Naik, Babatunde A Ogunnaike BMC Biophysics 2011, 4:15 (9 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cells can sense the availability of extracellular matrix binding sites and in response they regulate the sizes, shapes, and locations of integrin clusters that mediate cell adhesion to surrounding tissues.
	38. 64 Accesses	Research article Physical constraints on the establishment of intracellular spatial gradients in bacteria Carolina Tropini, Naveed Rabbani, Kerwyn Huang BMC Biophysics 2012, 5:17 (29 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	39. 62 Accesses	Research article Clustering of HIV-1 Subtypes Based on gp120 V3 Loop electrostatic properties Aliana López de Victoria, Chris A Kieslich, Apostolos K Rizos, Elias Krambovitis, Dimitrios Morikis BMC Biophysics 2012, 5:3 (7 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The spatial distributions of electrostatic potentials and charges in the V3 loop of HIV-1 protein gp120 may be responsible for both long- and short-range interactions with co-receptors, ultimately affecting viral entry into cells
	40. 61 Accesses	Research article A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction Jorge L Barreda, Huan-Xiang Zhou BMC Biophysics 2011, 4:5 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analytical solution to modeling the diffusion and reaction of acetylcholine in a neuromuscular junction and the binding of Ca2+ in a dyadic cleft provides a unique benchmark for testing numerical modeling methods.
	41. 60 Accesses	Research article Fluorescence anisotropy of diphenylhexatriene and its cationic Trimethylamino derivative in liquid dipalmitoylphosphatidylcholine liposomes: opposing responses to isoflurane Steven C Nelson, Steven K Neeley, Eric D Melonakos, John D Bell, David D Busath BMC Biophysics 2012, 5:5 (24 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Steady-state anisotropy of two fluorescent probes at different depths in a lipid bilayer reveals a decrease in anisotropy with increasing isoflurane anesthetic concentration, reflecting changes in the lateral pressure profile of the membrane.
	42. 54 Accesses	Software APM_GUI: analyzing particle movement on the cell membrane and determining confinement Silvia A Menchón, Mauricio G Martín, Carlos G Dotti BMC Biophysics 2012, 5:4 (20 February 2012) Abstract \| Full text \| PDF \| PubMed
	43. 54 Accesses	Research article Differences in adhesion and protrusion properties correlate with differences in migration speed under EGF stimulation Yue Hou, Sarah Hedberg, Ian C Schneider BMC Biophysics 2012, 5:8 (11 May 2012) Abstract \| Full text \| PDF \| PubMed
	44. 53 Accesses	Research article Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences Rasha Bassam, Ilya Digel, Juergen Hescheler, Ayseguel Temiz Artmann, Gerhard M Artmann BMC Biophysics 2013, 6:1 (4 January 2013) Abstract \| Full text \| PDF \| PubMed
	45. 45 Accesses	Review Gated Diffusion-controlled Reactions J Andrew McCammon BMC Biophysics 2011, 4:4 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Andy McCammon discusses both the protein-centric and detailed dynamic simulation methods that have been applied to predict rates of ligand binding and reactivity at protein active sites and the biological implications of these findings.
	46. 45 Accesses	Research article A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors Subhodeep Moitra, Kalyan C Tirupula, Judith Klein-Seetharaman, Christopher Langmead BMC Biophysics 2012, 5:13 (29 June 2012) Abstract \| Full text \| PDF \| PubMed
	47. 42 Accesses	Research article Characterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding Alexandra M Person, Gregg B Wells BMC Biophysics 2011, 4:19 (23 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Manipulation of maximum ligand and receptor concentrations and intentionally increasing ligand depletion are potentially helpful approaches to study low affinity binding of epibatidine to an independent binding site of alpha4beta2 nicotinic acetylcholine receptor.
	48. 33 Accesses	Research article Stability of double-stranded oligonucleotide DNA with a bulged loop: a microarray study Christian Trapp, Marc Schenkelberger, Albrecht Ott BMC Biophysics 2011, 4:20 (13 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Stable DNA duplexes with a bulged loop can form from short strands of unequal length with duplex stability decreasing monotonically with the length of the bulged loop, contributing substantially to microarray fluorescence intensity
	49. 33 Accesses	Research article Effects of spermine NONOate and ATP on the thermal stability of hemoglobin Rasha Bassam, Juergen Hescheler, Ayseguel Temiz-Artmann, Gerhard M Artmann, Ilya Digel BMC Biophysics 2012, 5:16 (28 August 2012) Abstract \| Full text \| PDF \| PubMed
	50. 32 Accesses	Editorial New horizons in Biophysics Elizabeth C Moylan BMC Biophysics 2011, 4:1 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary We are delighted to celebrate the re-launch of PMC Biophysics in its new format as BMC Biophysics with an expanded scope and Editorial Board and a special thematic series of articles on biological diffusion and Brownian dynamics.