BMC Biophysics | Most Viewed

Submit a manuscript Register Contact us Follow us on Twitter

Explore BMC Biophysics

Advertisement

Articles

Display/download options Articles per page: 25 | 50 | 100

Display options

Editor's summary Citation

Download options

Send
To

	All
	1. 743 Accesses	Research article Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations Haina Qin, Liangzhong Lim, Jianxing Song BMC Biophysics 2012, 5:2 (25 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| f1000 \| Editor’s summary Structural determination of the EphA4 ligand binding domain provides the first experimental and computational evidence that intrinsic dynamics are most likely to be responsible for the observed high conformational diversity that mediates binding affinity and specificity.
	2. 622 Accesses	Research article Physical constraints on the establishment of intracellular spatial gradients in bacteria Carolina Tropini, Naveed Rabbani, Kerwyn Huang BMC Biophysics 2012, 5:17 (29 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	3. 423 Accesses	Methodology article Improving accuracy of cell and chromophore concentration measurements using optical density John A Myers, Brandon S Curtis, Wayne R Curtis BMC Biophysics 2013, 6:4 (22 April 2013) Abstract \| Full text \| PDF
	4. 229 Accesses	Research article Self-consistent field theory for the interactions between keratin intermediate filaments Anna Akinshina, Etienne Jambon-Puillet, Patrick B Warren, Massimo G Noro BMC Biophysics 2013, 6:12 (5 September 2013) Abstract \| Full text \| PDF \| PubMed
	5. 219 Accesses	Commentary Activation of signaling receptors: do ligands bind to receptor monomer, dimer, or both? Xiaodong Pang, Huan-Xiang Zhou BMC Biophysics 2013, 6:7 (3 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Editor’s summary Xiaodong Pang and Huan-Xiang Zhou discuss a recent study in BMC Biophysics that sheds new light on mechanisms of receptor activation, and argue that coexistence of monomers and dimers may be common for cell surface receptors.
	6. 213 Accesses	Research article Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies Anke Steinbach, Christine K Maurer, Elisabeth Weidel, Claudia Henn, Christian Brengel, Rolf W Hartmann, Matthias Negri BMC Biophysics 2013, 6:10 (1 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	7. 202 Accesses	Research article Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells Marina S Dietz, Daniel Haße, Davide M Ferraris, Antonia Göhler, Hartmut H Niemann, Mike Heilemann BMC Biophysics 2013, 6:6 (3 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed \| Cited on BioMed Central \| Editor’s summary Single-molecule photobleaching reveals that the MET receptor exists as both dimers and monomers on cell membranes in the absence of a ligand, with the proportion of dimers increasing significantly upon ligand binding.
	8. 195 Accesses	Editorial Diffusion and association processes in biological systems: theory, computation and experiment Paolo Mereghetti, Daria Kokh, J Andrew McCammon, Rebecca C Wade BMC Biophysics 2011, 4:2 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rebecca Wade and colleagues provide a snapshot of research from a thematic series of articles on biological diffusion and Brownian dynamics simulations, which highlights a vibrant research field with growing synergy between experimental and computational studies.
	9. 169 Accesses	Research article Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase Maria L Kireeva, Kristopher Opron, Steve A Seibold, Céline Domecq, Robert I Cukier, Benoit Coulombe, Mikhail Kashlev, Zachary F Burton BMC Biophysics 2012, 5:11 (7 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The catalytic confirmation of the RNA polymerase ternary elongation complex (TEC) has a closed trigger loop with a relatively dehydrated active site, in contrast to the inactive open confirmation of the trigger loop which supports translocation.
	10. 153 Accesses	Research article Hierarchical super-structure identified by polarized light microscopy, electron microscopy and nanoindentation: Implications for the limits of biological control over the growth mode of abalone sea shells Andreas S Schneider, Birgit Heiland, Nicolas J Peter, Christina Guth, Eduard Arzt, Ingrid M Weiss BMC Biophysics 2012, 5:19 (12 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The hierarchical super-structure of abalone mollusc shells can be revealed by conventional light microscopy methods, opening the potential to study shell growth mechanisms in vivo at high resolution.
	11. 148 Accesses	Methodology article Time-resolved force distribution analysis Bogdan I Costescu, Frauke Gräter BMC Biophysics 2013, 6:5 (1 May 2013) Abstract \| Full text \| PDF \| ePUB \| Editor’s summary Time-resolved force distribution analysis is a new method to monitor the fluctuations of internal forces in complex macromolecular structures, and is an alternative approach to coordinate-based methods for analyzing structural transitions.
	12. 145 Accesses	Research article A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction Jorge L Barreda, Huan-Xiang Zhou BMC Biophysics 2011, 4:5 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analytical solution to modeling the diffusion and reaction of acetylcholine in a neuromuscular junction and the binding of Ca2+ in a dyadic cleft provides a unique benchmark for testing numerical modeling methods.
	13. 138 Accesses	Research article Many-particle Brownian and Langevin Dynamics Simulations with the Brownmove package Tihamér Geyer BMC Biophysics 2011, 4:7 (13 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new "brownmove" simulation package designed for coarse-grained many-particle simulations of biologically relevant diffusion and transport processes combines Brownian and Langevin Dynamics propagation with fast hydrodynamics, a flexible protein model and interfaces for "open" simulation settings.
	14. 138 Accesses	Correspondence Can dietary fibre help provide safer food products for sufferers of gluten intolerance? A well-established biophysical probe may help towards providing an answer M Kök, Richard Gillis, Shirley Ang, David Lafond, Arthur S Tatham, Gary Adams, Stephen E Harding BMC Biophysics 2012, 5:10 (17 May 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Stephen Harding and colleagues speculate on the role that the ultracentrifuge assay procedure could play in detecting non-toxic biopolymers capable of sequestering ingested gluten peptides, with the eventual aim of reducing gluten intolerance symptoms.
	15. 136 Accesses	Software DelPhi: a comprehensive suite for DelPhi software and associated resources Lin Li, Chuan Li, Subhra Sarkar, Jie Zhang, Shawn Witham, Zhe Zhang, Lin Wang, Nicholas Smith, Marharyta Petukh, Emil Alexov BMC Biophysics 2012, 5:9 (14 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The DelPhi package is a comprehensive and user-friendly suite of tools for modelling electrostatic potentials in macromolecules using the Poisson-Boltzmann Equation, and is now enriched with additional features for greater usability.
	16. 134 Accesses	Review Diffusion in crowded biological environments: applications of Brownian dynamics Maciej Długosz, Joanna Trylska BMC Biophysics 2011, 4:3 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Maciej Dlugosz and Joanna Trylska review recent developments in particle-based Brownian dynamics algorithms and their application to model diffusive transport in crowded systems, which are proving useful in improving our understanding of metabolism, transport and signaling.
	17. 126 Accesses	Research article Introduction of non-linear elasticity models for characterization of shape and deformation statistics: application to contractility assessment of isolated adult cardiocytes Carlos Bazan, Trevor Hawkins, David Torres-Barba, Peter Blomgren, Paul Paolini BMC Biophysics 2011, 4:17 (22 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel image analysis approach to assess cardiocyte contractility successfully captures the full extent of contractile behavior by incorporating biomechanical properties, energy conservation principles and information content measures.
	18. 126 Accesses	Review Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations Balaji VS Iyer, Martin Kenward, Gaurav Arya BMC Biophysics 2011, 4:8 (15 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gaurav Arya and colleagues review results from state-of-the-art microscopy and chromosome conformation capture techniques that are being used to understand the three dimensional structure of the genome and the physical principles governing its folding.
	19. 125 Accesses	Research article Kinetic effects of TiO₂ fine particles and nanoparticles aggregates on the nanomechanical properties of human neutrophils assessed by force spectroscopy Everton Luis da Rosa BMC Biophysics 2013, 6:11 (19 August 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	20. 125 Accesses	Research article Spindles and active vortices in a model of confined filament-motor mixtures David A Head, WJ Briels, Gerhard Gompper BMC Biophysics 2011, 4:18 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A discrete filament-motor protein model of subcellular microtubule self-assembly in fission yeast spontaneously generates a number of steady states, including spindles, nematics, and asters, highlighting potential mechanisms for self-organisation in filaments
	21. 119 Accesses	Research article Molecular dynamics simulations on aqueous two-phase systems - Single PEG-molecules in solution Stefan A Oelmeier, Florian Dismer, Jürgen Hubbuch BMC Biophysics 2012, 5:14 (8 August 2012) Abstract \| Full text \| PDF \| PubMed
	22. 119 Accesses	Research article Drop drying on surfaces determines chemical reactivity - the specific case of immobilization of oligonucleotides on microarrays Jens Sobek, Catharine Aquino, Wilfried Weigel, Ralph Schlapbach BMC Biophysics 2013, 6:8 (12 June 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	23. 116 Accesses	Research article Clustering of HIV-1 Subtypes Based on gp120 V3 Loop electrostatic properties Aliana López de Victoria, Chris A Kieslich, Apostolos K Rizos, Elias Krambovitis, Dimitrios Morikis BMC Biophysics 2012, 5:3 (7 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The spatial distributions of electrostatic potentials and charges in the V3 loop of HIV-1 protein gp120 may be responsible for both long- and short-range interactions with co-receptors, ultimately affecting viral entry into cells
	24. 112 Accesses	Research article An upper limit for macromolecular crowding effects Andrew C Miklos, Conggang Li, Courtney D Sorrell, L Andrew Lyon, Gary J Pielak BMC Biophysics 2011, 4:13 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Synthetic microgels that interact weakly with proteins do not strongly influence protein dynamics or stability because these large microgels constitute an upper size limit on crowding effects.
	25. 108 Accesses	Research article Wavelet-based protocols for ion channel electrophysiology Armin Kargol BMC Biophysics 2013, 6:3 (14 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed