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Volume 5 (2012) - January 2012

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Research article   Open Access Highly Accessed

Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations

Haina Qin, Liangzhong Lim, Jianxing Song BMC Biophysics 2012, 5:2 (25 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Structural determination of the EphA4 ligand binding domain provides the first experimental and computational evidence that intrinsic dynamics are most likely to be responsible for the observed high conformational diversity that mediates binding affinity and specificity.

Research article   Open Access

Using default constraints of the spindle assembly checkpoint to estimate the associated chemical rates

Khanh Dao Duc, David Holcman BMC Biophysics 2012, 5:1 (19 January 2012)

Abstract | Full text | PDF | PubMed