Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development
BMC Biology 2015, 13:42 (20 June 2015)
The tumour suppressor APC plays a critical role in cancer growth, largely through its negative regulation of the Wnt pathway. Shi and colleagues investigate the role of APC in mesenchymal cells in the developing lung, and find surprising results in both the breadth and downstream effects of APC’s dysregulation.
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
BMC Biology 2013, 11:114 (19 November 2013)