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1.
Q&A: Antibiotic resistance: what more do we know and what more can we do?
Gerard D Wright BMC Biology 2013, 11 :51 (17 May 2013)
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Editor’s summary
Antibiotic resistance is both an ancient phenomenon and a worsening medical problem. Gerard Wright explains why, and what should be done about it.
2.
On the origin of POU5F1
Stephen Frankenberg, Marilyn B Renfree BMC Biology 2013, 11 :56 (9 May 2013)
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3.
Somatic and visceral nervous systems - an ancient duality
Paola Bertucci, Detlev Arendt BMC Biology 2013, 11 :54 (30 April 2013)
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Editor’s summary
The idea that vertebrates are composed of a ‘visceral’ and ‘somatic’ self, responding to internal and external stimuli, respectively, was first put forward in the 19th century. Now, molecular fingerprinting indicates a duality between the somatic and visceral nervous systems that appears to predate Bilataria.
4.
Spatial and temporal in vivo analysis of circulating and sessile immune cells in mosquitoes: hemocyte mitosis following infection
Jonas G King, Julián F Hillyer BMC Biology 2013, 11 :55 (30 April 2013)
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Editor’s summary
Observations on the number, location, phagocytic activity and cell division of hemocytes in the body cavity of mosquitoes sheds new light on the biology of insect immune system cells.
5.
Ancient origin of somatic and visceral neurons
Marc Nomaksteinsky, Stefan Kassabov, Zoubida Chettouh, Henri-Corto Stoeklé, Laure Bonnaud, Gilles Fortin, Eric R Kandel, Jean-François Brunet BMC Biology 2013, 11 :53 (30 April 2013)
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Editor’s summary
The great American palaeontologist and anatomist Alfred Romer speculated that early in animal life, an emerging somatic nervous system, focused on the outside world, struggled to dominate the visceral nervous system that takes care of the internal systems that keep us alive. Jean-François Brunet and colleagues identify the molecular signatures that tell the evolutionary tale of this duality.
6.
Statistical support for the hypothesis of developmental constraint in marsupial skull evolution
C Verity Bennett, Anjali Goswami BMC Biology 2013, 11 :52 (26 April 2013)
Abstract | Provisional PDF
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7.
High-density linkage mapping in a pine tree reveals a genomic region associated with inbreeding depression and provides clues to the extent and distribution of meiotic recombination
Emilie Chancerel, Jean-Baptiste Lamy, Isabelle Lesur, Céline Noirot, Christophe Klopp, François Ehrenmann, Christophe Boury, Grégoire Le Provost, Philippe Label, Céline Lalanne, Valérie Léger, Franck Salin, Jean-Marc Gion, Christophe Plomion BMC Biology 2013, 11 :50 (18 April 2013)
Abstract | Provisional PDF
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8.
Radial glial cells play a key role in echinoderm neural regeneration
Vladimir S Mashanov, Olga R Zueva, José E García-Arrarás BMC Biology 2013, 11 :49 (18 April 2013)
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Editor’s summary
Repair of a cut radial nerve cord in a sea cucumber is mediated by radial glial cells that dedifferentiate, divide and give rise to new neurons.
9.
Tropical rain forest evolution: palms as a model group
Thomas LP Couvreur, William J Baker BMC Biology 2013, 11 :48 (15 April 2013)
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10.
Seeing the Tree of Life behind the phylogenetic forest
Pere Puigbò, Yuri I Wolf, Eugene V Koonin BMC Biology 2013, 11 :46 (15 April 2013)
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11.
Arthropods and inherited bacteria: from counting the symbionts to understanding how symbionts count
Olivier Duron, Gregory DD Hurst BMC Biology 2013, 11 :45 (15 April 2013)
Full text | PDF | PubMed | Cited on BioMed Central
12.
Fuzzy species revisited
William P Hanage BMC Biology 2013, 11 :41 (15 April 2013)
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13.
The new micro-kingdoms of eukaryotes
Jan Pawlowski BMC Biology 2013, 11 :40 (15 April 2013)
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14.
Tenth anniversary updates from our authors
Penelope Austin, Kester Jarvis BMC Biology 2013, 11 :39 (15 April 2013)
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15.
Of flies and men: insights on organismal metabolism from fruit flies
Akhila Rajan, Norbert Perrimon BMC Biology 2013, 11 :38 (15 April 2013)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
For many reasons metabolism is now a high-profile topic, and in an update to mark the tenth anniversary of BMC Biology , Norbert Perrimon and Akhila Rajan review the remarkable similarities that make Drosophila a model for mammalian metabolism, and some recent advances made possible by the advantages of this model organism.
16.
A view forward from ten years of BMC Biology
Miranda Robertson BMC Biology 2013, 11 :32 (15 April 2013)
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17.
Mitochondrial genomes as living ‘fossils’
Ian Small BMC Biology 2013, 11 :30 (15 April 2013)
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Editor’s summary
Ian Small discusses why the "fossilised" mitochondrial genome of Liriodendron could have such a slow mutation rate, and what it might tell us about the evolution of RNA editing.
18.
The “fossilized” mitochondrial genome of Liriodendron tulipifera : ancestral gene content and order, ancestral editing sites, and extraordinarily low mutation rate
Aaron O Richardson, Danny W Rice, Gregory J Young, Andrew J Alverson, Jeffrey D Palmer BMC Biology 2013, 11 :29 (15 April 2013)
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Editor’s summary
The mitochondrial genome of the tulip tree has a remarkably slow rate of nucleotide substitution, and could offer insight into the content and organisation of this genome in the ancestral flowering plant.
19.
Biological functions of natural antisense transcripts
Andreas Werner BMC Biology 2013, 11 :31 (12 April 2013)
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20.
Q&A: Who needs a centrosome?
Mónica Bettencourt-Dias BMC Biology 2013, 11 :28 (11 April 2013)
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Editor’s summary
The centrosome is classically regarded as the microtubule-organizing center of the cell. But cells can divide without them, and exactly what they do is largely mysterious. In a Q&A article in a series on cell geometry, Monica Bettencourt-Dias asks what we do know and what we don’t, about normal centrosomes and the abnormalities underlying disease.
21.
The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling
Roman H Khonsari, Maisa Seppala, Alan Pradel, Hugo Dutel, Gaël Clément, Oleg Lebedev, Sarah Ghafoor, Michaela Rothova, Abigael Tucker, John G Maisey, Chen-Ming Fan, Maiko Kawasaki, Atsushi Ohazama, Paul Tafforeau, Brunella Franco, Jill Helms, Courtney J Haycraft, Albert David, Philippe Janvier, Martyn T Cobourne, Paul T Sharpe BMC Biology 2013, 11 :27 (28 March 2013)
Abstract | Full text | PDF | PubMed
22.
Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio )
Alexander G Little, Tatsuya Kunisue, Kurunthachalam Kannan, Frank Seebacher BMC Biology 2013, 11 :26 (26 March 2013)
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Editor’s summary
Thyroid hormone plays an important part in adaptation to changing ambient temperature conditions in mammals, but surprisingly, its role in such adaptation in ectotherms is not known. Alexander Little and colleagues report investigations on zebrafish that suggest it is important for cold-blooded vertebrate adaptation too.
23.
Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae
Michaela de Clare, Stephen G Oliver BMC Biology 2013, 11 :24 (25 March 2013)
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Editor’s summary
An analysis of the effect of copy number variation on growth, apoptosis and the cell cycle for a selected subset of Saccharomyces cerevisiae genes suggests that using this model yeast to predict the effects of similar copy number variants in human cancers is a worthwhile approach.
24.
Frequency of intron loss correlates with processed pseudogene abundance: a novel strategy to test the reverse transcriptase model of intron loss
Tao Zhu, Deng-Ke Niu BMC Biology 2013, 11 :23 (5 March 2013)
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Editor’s summary
It is well established that intron loss is common in gene evolution, but three competing theories have been proposed to explain it. A new study supports the model involving reverse transcription, by analysing genomic byproducts of reverse transcriptase activity.
25.
Molecular basis for prey relocation in viperid snakes
Anthony J Saviola, David Chiszar, Chardelle Busch, Stephen P Mackessy BMC Biology 2013, 11 :20 (1 March 2013)
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Editor’s summary
Viperid snakes bite their prey and then let them go to avoid retaliation. By measuring snake behavior and analysing venom chemistry, Stephen Mackessy and colleagues provide an answer to how they find them again.