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	1. 40432 Accesses	Research article scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby BMC Biology 2009, 7:62 (24 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Scribble, a cell polarity regulator in Drosophila, represses tumorigenesis by inhibiting atypical protein kinase C and Jun N-terminal kinase-dependent pathways, and this might be relevant for how human Scrib restrains oncogene-mediated transformation.
	2. 26586 Accesses	Review Molecular dynamics simulations and drug discovery Jacob D Durrant, J Andrew McCammon BMC Biology 2011, 9:71 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Modeling the movements of atoms within macromolecules can predict their conformational flexibility to inform drug discovery. Jacob Durrant and Andrew McCammon explain how this is done in molecular dynamics simulations, reviewing both the successes and current limitations of the approach.
	3. 23646 Accesses	Question and Answer Q&A: 'Toxic' effects of sugar: should we be afraid of fructose? Luc Tappy BMC Biology 2012, 10:42 (21 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Before the colonial era of sugar plantations we consumed, on average, about 15-fold less fructose than we do today. Luc Tappy explains, in question and answer format, the special features of fructose metabolism and discusses the evidence that high fructose intake has contributed to the current epidemic of obesity and metabolic disease.
	4. 22215 Accesses	Question and Answer Q&A: What is the Golgi apparatus, and why are we asking? Sean Munro BMC Biology 2011, 9:63 (30 September 2011) Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary Sean Munro explains in Q&A format why the Golgi apparatus remains a gently seething cauldron of controversy more than 120 years after its discovery.
	5. 18908 Accesses	Forum What does the concept of the stem cell niche really mean today? Arthur D Lander, Judith Kimble, Hans Clevers, Elaine Fuchs, Didier Montarras, Margaret Buckingham, Anne L Calof, Andreas Trumpp, Thordur Oskarsson BMC Biology 2012, 10:19 (9 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary How do current researchers view the stem cell niche? Eight experts from different fields provide their perspective, and ask how stem cells evolve in such an environment, launching a new Forum article type within the cross-journal collection on stem cells.
	6. 13501 Accesses	Review Microarrays, deep sequencing and the true measure of the transcriptome John H Malone, Brian Oliver BMC Biology 2011, 9:34 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Global measures of gene expression can now be extracted either from microarrays or from RNA-seq, which do not always seem to give the same answer. Malone and Oliver review the advantages and limitations of each and conclude that, with some important exceptions, they tell the same story.
	7. 12064 Accesses	Question and Answer Q&A: What is a pathogen? A question that begs the point Liise-anne Pirofski, Arturo Casadevall BMC Biology 2012, 10:6 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Arturo Casadevall and Liise-anne Pirofski explain in Q&A format the emergent properties of microbial pathogenesis that make the question impossible to answer, and the emergence of new pathogens almost impossible to predict.
	8. 11043 Accesses	Methodology article Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation Maria Vinci, Sharon Gowan, Frances Boxall, Lisa Patterson, Miriam Zimmermann, William Court, Cara Lomas, Marta Mendiola, David Hardisson, Suzanne A Eccles BMC Biology 2012, 10:29 (22 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A high throughput method to assay for the growth, invasiveness and angiogenic activity of tumor cells grown in 3-dimensions is validated by testing known cancer drugs, and offers a tool-kit for testing new ones.
	9. 8362 Accesses	Forum What determines cell size? Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu, Adrienne HK Roeder BMC Biology 2012, 10:101 (14 December 2012) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary In a Forum article in the Cell geometry series, ten experts in ten different systems explain why it matters what size a cell is, and offer ten different answers on how it is controlled – probably all of them right.
	10. 7937 Accesses	Research article The first metazoa living in permanently anoxic conditions Roberto Danovaro, Antonio Dell'Anno, Antonio Pusceddu, Cristina Gambi, Iben Heiner, Reinhardt Møbjerg Kristensen BMC Biology 2010, 8:30 (6 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| F1000 Biology \| Editor’s summary An expedition to a deep sea hypersaline anoxic basin in the Mediterranean has discovered the first multicellular animals that live and reproduce in the absence of oxygen.
	11. 7511 Accesses	Research article Evidence that a West-East admixed population lived in the Tarim Basin as early as the early Bronze Age Chunxiang Li, Hongjie Li, Yinqiu Cui, Chengzhi Xie, Dawei Cai, Wenying Li, Victor H Mair, Zhi Xu, Quanchao Zhang, Idelisi Abuduresule, Li Jin, Hong Zhu, Hui Zhou BMC Biology 2010, 8:15 (17 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genetic analysis of human remains from the Tarim Basin in China reveals that the Xiaohe people comprised an admixture of populations originating from both the East and the West dating from the early Bronze Age.
	12. 7349 Accesses	Opinion Logic modeling and the ridiculome under the rug Michael L Blinov, Ion I Moraru BMC Biology 2012, 10:92 (21 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary What is logic modeling useful for? Blinov and Moraru explain its uses for cell biologists - with recent examples of a whole-cell computational model of a prokaryote and a modeling platform for cell signaling.
	13. 7271 Accesses	Comment Mending walls Gregory A Petsko BMC Biology 2012, 10:41 (11 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The real topic of Gregory Petsko's Comment in our Metabolism diet and disease series is not, despite its title, mending walls, but patterns of comorbidity that argue for cross-disciplinary research: obesity and cancer are linked, for example, but apparently not if you are also schizophrenic.
	14. 7260 Accesses	Editorial What is wrong with this picture? Miranda Robertson BMC Biology 2012, 10:76 (3 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary BMC Biology has always acknowledged that the phylogeny encompassed in its iconic microcell is an artistic distortion of the reality, but had not realized it is actually wrong. Miranda Robertson explains in a short editorial, and invites further corrections.
	15. 7049 Accesses	Question and Answer Q&A: ChIP-seq technologies and the study of gene regulation Edison T Liu, Sebastian Pott, Mikael Huss BMC Biology 2010, 8:56 (14 May 2010) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Edison Liu and colleagues explain in Q&A format how ChIP-seq technology allows investigation of transcriptional regulation on a genomic scale, and what is next.
	16. 6786 Accesses	Methodology article Rapid production of antigen-specific monoclonal antibodies from a variety of animals Nobuyuki Kurosawa, Megumi Yoshioka, Rika Fujimoto, Fuminori Yamagishi, Masaharu Isobe BMC Biology 2012, 10:80 (28 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Using a fluorescent dye to label the greatly expanded endoplasmic reticulum characteristic of antibody-secreting cells, Kurosawa and colleagues demonstrate how monoclonal antibodies can be produced from a variety of immunized animals in just one week.
	17. 6685 Accesses	Research article Cnidocyte discharge is regulated by light and opsin-mediated phototransduction David C Plachetzki, Caitlin R Fong, Todd H Oakley BMC Biology 2012, 10:17 (5 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Sting cell discharge in the eyeless cnidarian hydra is regulated by opsin-mediated phototransduction, a pathway used in vision in other animals.
	18. 6608 Accesses	Methodology article Use of the viral 2A peptide for bicistronic expression in transgenic mice Georgios Trichas, Jo Begbie, Shankar Srinivas BMC Biology 2008, 6:40 (15 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Germline transmission of a bicistronic vector using the 2A peptide to allow co-translational cleavage is stable in mice and shows no developmental side-effects, giving a superior alternative to the internal ribosomal entry site for expressing multiple transgenes.
	19. 6596 Accesses	Research article Macondo crude oil from the Deepwater Horizon oil spill disrupts specific developmental processes during zebrafish embryogenesis T Yvanka de Soysa, Allison Ulrich, Timo Friedrich, Danielle Pite, Shannon L Compton, Deborah Ok, Rebecca L Bernardos, Gerald B Downes, Shizuka Hsieh, Rachael Stein, M Caterina Lagdameo, Katherine Halvorsen, Lydia-Rose Kesich, Michael JF Barresi BMC Biology 2012, 10:40 (4 May 2012) Abstract \| Full text \| PDF \| PubMed
	20. 6511 Accesses	Research article Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model Bhupinder Virk, Gonçalo Correia, David P Dixon, Inna Feyst, Jie Jia, Nikolin Oberleitner, Zoe Briggs, Emily Hodge, Robert Edwards, John Ward, David Gems, David Weinkove BMC Biology 2012, 10:67 (31 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary David Weinkove and colleagues report an accidental discovery in C. elegans that has led them to a series of studies implicating folate in excess of needs in limiting lifespan, with interesting hints from the effects of sulfonamide drugs that the same may apply to mammals.
	21. 6462 Accesses	Research article Updating the evolutionary history of Carnivora (Mammalia): a new species-level supertree complete with divergence time estimates Katrin Nyakatura, Olaf RP Bininda-Emonds BMC Biology 2012, 10:12 (27 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new "supertree" phylogeny covering all carnivore species has been constructed, with revised groupings representing the advances in phylogenetic practice since the previous complete tree was published in 1999.
	22. 6139 Accesses	Research article Phylogenomic analyses support the position of turtles as the sister group of birds and crocodiles (Archosauria) Ylenia Chiari, Vincent Cahais, Nicolas Galtier, Frédéric Delsuc BMC Biology 2012, 10:65 (27 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Turtles have traditionally been hard to place taxonomically because of their unique morphology, and recent research based on microRNA has stirred the pot once again. Contrary to that work, phylogenomic analysis of a large new sequence data set adds strong support to the previous conclusion that turtles' closest evolutionary relatives are birds and crocodiles.
	23. 6008 Accesses	Question and Answer Q&A: Antibiotic resistance: where does it come from and what can we do about it? Gerard D Wright BMC Biology 2010, 8:123 (20 September 2010) Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary As long as we continue to use antibiotics the development of resistance is inevitable. Gerard Wright explains why it is an increasing problem, and what can be done about it.
	24. 5984 Accesses	Research article The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ Daniel N Düring, Alexander Ziegler, Christopher K Thompson, Andreas Ziegler, Cornelius Faber, Johannes Müller, Constance Scharff, Coen PH Elemans BMC Biology 2013, 11:1 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The three-dimensional anatomy of the zebra finch vocal organ is described in unprecedented detail, providing new insights into the biomechanics of song production in a species widely used as an experimental model for vocal learning.
	25. 5934 Accesses	Comment Dangerous for ferrets: lethal for humans? Peter C Doherty, Paul G Thomas BMC Biology 2012, 10:10 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Research on how highly pathogenic H5N1 viruses might become transmissible between humans has ignited heated debate on the balance of risks and benefits of such experiments. Peter Doherty and Paul Thomas give their view.