BMC Biology | Most Viewed

Submit a manuscript Register Contact us Follow us on Twitter

Explore BMC Biology

Advertisement

Articles

Display/download options Articles per page: 25 | 50 | 100

Display options

Editor's summary Citation

Download options

Send
To

	All
	51. 12631 Accesses	Opinion Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine Myron M Levine BMC Biology 2010, 8:129 (4 October 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Oral vaccines are least effective where they are most needed, in developing countries with poor sanitation and limited resources of skilled medical personnel. Myron Levine draws on his experience with cholera vaccine to suggest why, and what can be done about it.
	52. 12540 Accesses	Research article The planetary biology of cytochrome P450 aromatases Eric A Gaucher, Logan G Graddy, Tang Li, Rosalia CM Simmen, Frank A Simmen, David R Schreiber, David A Liberles, Christine M Janis, Steven A Benner BMC Biology 2004, 2:19 (17 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The duplication of the pig aromatase genes involved in estrogen production coincided with the evolution of larger litter sizes during climatic change in the Eocene.
	53. 12375 Accesses	Research article Environmentally-acquired bacteria influence microbial diversity and natural innate immune responses at gut surfaces Imke E Mulder, Bettina Schmidt, Christopher R Stokes, Marie Lewis, Mick Bailey, Rustam I Aminov, James I Prosser, Bhupinder P Gill, John R Pluske, Claus-Dieter Mayer, Corran C Musk, Denise Kelly BMC Biology 2009, 7:79 (20 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Pigs reared indoors or in isolation have a less healthy gut microbiota than outdoor-reared pigs, and signs of immune activation in gut tissues, reinforcing human data associating childhood hygiene with inflammatory bowel disease.
	54. 12275 Accesses	Research article African-American mitochondrial DNAs often match mtDNAs found in multiple African ethnic groups Bert Ely, Jamie Wilson, Fatimah Jackson, Bruce A Jackson BMC Biology 2006, 4:34 (12 October 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Only a small fraction of African American mtDNA haplotypes uniquely match databased mtDNA haplotypes, suggesting that more haplotypes need to be identified if African Americans are to be able to trace their African ancestry.
	55. 12171 Accesses	Research article Evolution and diversity of Rickettsia bacteria Lucy A Weinert, John H Werren, Alexandre Aebi, Graham N Stone, Francis M Jiggins BMC Biology 2009, 7:6 (2 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Twenty new strains of Rickettsia have been identified and although some species cause disease in mammals and can infect protists, they comprise only a few branches of the phylogenetic tree and the bacteria primarily infect arthropods.
	56. 12153 Accesses	Question and Answer Q&A: Life, synthetic biology and risk Steven A Benner BMC Biology 2010, 8:77 (14 June 2010) Full text \| PDF \| PubMed \| Editor’s summary What is life? In a Q&A, Steven Benner explains, in the light of recent developments in Craig Venter's laboratory, his point of view on the definition of life, and on the dangers of both natural and synthetic forms.
	57. 11976 Accesses	Research article Wnt5 signaling in vertebrate pancreas development Hyon J Kim, Jack R Schleiffarth, Jose Jessurun, Saulius Sumanas, Anna Petryk, Shuo Lin, Stephen C Ekker BMC Biology 2005, 3:23 (24 October 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary An interaction of Wnt-5 with Fz-2 is critical for insulin cell migration in the zebrafish, and this requirement of Wnt-5 signaling for pancreatic development is conserved in the mouse.
	58. 11970 Accesses	Editorial Pit-bull reviewing, the pursuit of perfection and the victims of success Miranda Robertson BMC Biology 2011, 9:84 (1 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The festering discontent with reviewing and editorial practices in the high-profile biology journals has erupted into a new high-quality open access journal to be launched in 2012. Miranda Robertson explores the problem and the solutions offered, and revisits the re-review opt-out policy operated by BMC Biology.
	59. 11874 Accesses	Research article PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors Enrico K Schmidt, Serge Fichelson, Stephan M Feller BMC Biology 2004, 2:7 (18 May 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary When applied to blood cell progenitors in physiological concentrations, erythropoietin induces a pathway that unexpectedly uses PI3 kinase gamma to activate mitogenic kinases, which mediate cell proliferation.
	60. 11853 Accesses	Research article A rapidly evolving secretome builds and patterns a sea shell Daniel J Jackson, Carmel McDougall, Kathryn Green, Fiona Simpson, Gert Wörheide, Bernard M Degnan BMC Biology 2006, 4:40 (22 November 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel expression analysis of genes involved in the formation and patterning of the mollusk shell reveals the unexpected complexity of molecular mechanisms governing the formation and pigmentation of mineralized structures.
	61. 11767 Accesses	Research article Single-copy nuclear genes resolve the phylogeny of the holometabolous insects Brian M Wiegmann, Michelle D Trautwein, Jung-Wook Kim, Brian K Cassel, Matthew A Bertone, Shaun L Winterton, David K Yeates BMC Biology 2009, 7:34 (24 June 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Twisted wing parasites (Strepsiptera), an enigmatic order of insects that has posed a long-standing riddle for taxonomists, are closely related to beetles according to a new phylogeny of holometabolous insects based on six nuclear genes.
	62. 11759 Accesses	Research article Reconstructing the ups and downs of primate brain evolution: implications for adaptive hypotheses and Homo floresiensis Stephen H Montgomery, Isabella Capellini, Robert A Barton, Nicholas I Mundy BMC Biology 2010, 8:9 (27 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Brain expansion began early in primate evolution and has occurred in all major clades, however in some lineages this trend has been reversed, accomodating plausible scenarios for the evolution of the small-brained hominin, Homo floresiensis.
	63. 11705 Accesses	Commentary Not just another genome Diethard Tautz BMC Biology 2011, 9:8 (4 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The genome of Daphnia pulex reveals a surprising number of novel genes compared with other arthropod genomes. Tautz suggests how environmental factors and life-cycle quirks may explain this remarkable genomic plasticity, and consequent rate of adaptation, in Daphnia.
	64. 11653 Accesses	Editorial The noncoding universe Kester Jarvis, Miranda Robertson BMC Biology 2011, 9:52 (28 July 2011) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary In an editorial revisiting the controversy on the extent of the noncoding transcriptome, BMC Biology concludes that the bioinformatic facts are becoming clearer but their biological meaning remains obscure.
	65. 11646 Accesses	Research article Ocean climate and seal condition Burney J Le Boeuf, Daniel E Crocker BMC Biology 2005, 3:9 (28 March 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The condition of elephant seal pups in the Pacific is negatively affected by warmer oceans, such as those seen in El Nino years, due to a change in prey distribution which decreases the foraging success of females.
	66. 11583 Accesses	Forum What determines cell size? Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu, Adrienne HK Roeder BMC Biology 2012, 10:101 (14 December 2012) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary In a Forum article in the Cell geometry series, ten experts in ten different systems explain why it matters what size a cell is, and offer ten different answers on how it is controlled – probably all of them right.
	67. 11487 Accesses	Research article TbAGO1, an Argonaute protein required for RNA interference, is involved in mitosis and chromosome segregation in Trypanosoma brucei Mickaël Durand-Dubief, Philippe Bastin BMC Biology 2003, 1:2 (12 December 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Argonaute protein TbAGO1 is essential for the post-transcriptional destruction of RNA in Trypanosoma brucei. Knockout of this molecule leads to deficits in mitotic spindle assembly and chromosome segregation.
	68. 11464 Accesses	Research article Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress? Susana Peciña, Jay Schulkin, Kent C Berridge BMC Biology 2006, 4:8 (13 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Corticotropin-releasing factor is a stress hormone but a study in rats shows it is also associated with exaggerated reward craving, which may explain why stress in humans can trigger binge eating or drug relapses.
	69. 11454 Accesses	Opinion The edges of understanding Arthur D Lander BMC Biology 2010, 8:40 (12 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Mathematical models of biological systems are never ‘right’, but they are essential for understanding.
	70. 11393 Accesses	Research article Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation Christina Kaiser, Stephen R James BMC Biology 2004, 2:23 (2 November 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Acetylation of IRS-1, a key moderator of insulin action, facilitates its tyrosine phosphorylation and insulin-stimulated signal transduction.
	71. 11363 Accesses	Research article Induced metamorphosis in crustacean y-larvae: Towards a solution to a 100-year-old riddle Henrik Glenner, Jens T Høeg, Mark J Grygier, Yoshihisa Fujita BMC Biology 2008, 6:21 (20 May 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The 'adult' form of the enigmatic crustacean y-larva has never been found but can be artificially induced with molting hormones, suggesting that the adult phase does indeed exist, probably as an endoparasite within a marine host.
	72. 11244 Accesses	Research article Microtubule plus-ends reveal essential links between intracellular polarization and localized modulation of endocytosis during division-plane establishment in plant cells Pankaj Dhonukshe, Jaideep Mathur, Martin Hülskamp, Theodorus WJ Gadella BMC Biology 2005, 3:11 (14 April 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A study in plant cells with labeled microtubule plus-ends reveals that polarized microtubule growth accompanies localization of endocytic vesicles at the future division plane, while disrupting polarization with an auxin inhibitor produces abnormal division planes.
	73. 11231 Accesses	Research article Rapid sympatric ecological differentiation of crater lake cichlid fishes within historic times Kathryn R Elmer, Topi K Lehtonen, Andreas F Kautt, Chris Harrod, Axel Meyer BMC Biology 2010, 8:60 (12 May 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Since colonising a crater lake only about 100 years ago, Midas cichlid fish have diverged into fat and thin-lipped morphs with distinct diets, suggesting a process of incipient speciation.
	74. 11113 Accesses	Research article Ab initio modeling of small proteins by iterative TASSER simulations Sitao Wu, Jeffrey Skolnick, Yang Zhang BMC Biology 2007, 5:17 (8 May 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Modeling the three-dimensional structures of proteins from their amino acid sequence is possible using the Iterative TASSER (Threading/ASSEmbly/Refinement) method, which correctly predicts folds for small single-domain proteins faster than existing methods.
	75. 11032 Accesses	Research article Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D₃receptor Jeffrey N Joyce, Cheryl Woolsey, Han Ryoo, Sabine Borwege, Diane Hagner BMC Biology 2004, 2:22 (11 October 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Low doses of pramipexole protect against MPTP-induced dopamine neuron and fibre loss in a Parkinson's disease mouse model, probably acting via the D3 receptor to downregulate the dopamine transporter.