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	1. 65242 Accesses	Research article The first metazoa living in permanently anoxic conditions Roberto Danovaro, Antonio Dell'Anno, Antonio Pusceddu, Cristina Gambi, Iben Heiner, Reinhardt Møbjerg Kristensen BMC Biology 2010, 8:30 (6 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| F1000 Biology \| Editor’s summary An expedition to a deep sea hypersaline anoxic basin in the Mediterranean has discovered the first multicellular animals that live and reproduce in the absence of oxygen.
	2. 47505 Accesses	Research article scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby BMC Biology 2009, 7:62 (24 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Scribble, a cell polarity regulator in Drosophila, represses tumorigenesis by inhibiting atypical protein kinase C and Jun N-terminal kinase-dependent pathways, and this might be relevant for how human Scrib restrains oncogene-mediated transformation.
	3. 32040 Accesses	Review Molecular dynamics simulations and drug discovery Jacob D Durrant, J Andrew McCammon BMC Biology 2011, 9:71 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Modeling the movements of atoms within macromolecules can predict their conformational flexibility to inform drug discovery. Jacob Durrant and Andrew McCammon explain how this is done in molecular dynamics simulations, reviewing both the successes and current limitations of the approach.
	4. 30643 Accesses	Research article Extensive population genetic structure in the giraffe David M Brown, Rick A Brenneman, Klaus-Peter Koepfli, John P Pollinger, Borja Milá, Nicholas J Georgiadis, Edward E Louis, Gregory F Grether, David K Jacobs, Robert K Wayne BMC Biology 2007, 5:57 (21 December 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Giraffes can travel widely but have recently been found to comprise eleven genetically distinct populations with little interbreeding, a finding which is unprecedented among large African mammals with significant implications for giraffe conservation management.
	5. 30461 Accesses	Question and Answer Q&A: What is the Golgi apparatus, and why are we asking? Sean Munro BMC Biology 2011, 9:63 (30 September 2011) Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary Sean Munro explains in Q&A format why the Golgi apparatus remains a gently seething cauldron of controversy more than 120 years after its discovery.
	6. 29784 Accesses	Research article Pair of lice lost or parasites regained: the evolutionary history of anthropoid primate lice David L Reed, Jessica E Light, Julie M Allen, Jeremy J Kirchman BMC Biology 2007, 5:7 (7 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The coevolution of parasitic lice on primate hosts involved cospeciation and host switching, resulting in humans sharing body lice with gorillas and head lice being shared between humans and chimpanzees.
	7. 27520 Accesses	Review Microarrays, deep sequencing and the true measure of the transcriptome John H Malone, Brian Oliver BMC Biology 2011, 9:34 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Global measures of gene expression can now be extracted either from microarrays or from RNA-seq, which do not always seem to give the same answer. Malone and Oliver review the advantages and limitations of each and conclude that, with some important exceptions, they tell the same story.
	8. 25998 Accesses	Methodology article Use of the viral 2A peptide for bicistronic expression in transgenic mice Georgios Trichas, Jo Begbie, Shankar Srinivas BMC Biology 2008, 6:40 (15 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Germline transmission of a bicistronic vector using the 2A peptide to allow co-translational cleavage is stable in mice and shows no developmental side-effects, giving a superior alternative to the internal ribosomal entry site for expressing multiple transgenes.
	9. 24222 Accesses	Research article Evidence that a West-East admixed population lived in the Tarim Basin as early as the early Bronze Age Chunxiang Li, Hongjie Li, Yinqiu Cui, Chengzhi Xie, Dawei Cai, Wenying Li, Victor H Mair, Zhi Xu, Quanchao Zhang, Idelisi Abuduresule, Li Jin, Hong Zhu, Hui Zhou BMC Biology 2010, 8:15 (17 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genetic analysis of human remains from the Tarim Basin in China reveals that the Xiaohe people comprised an admixture of populations originating from both the East and the West dating from the early Bronze Age.
	10. 24210 Accesses	Question and Answer Q&A: Antibiotic resistance: where does it come from and what can we do about it? Gerard D Wright BMC Biology 2010, 8:123 (20 September 2010) Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary As long as we continue to use antibiotics the development of resistance is inevitable. Gerard Wright explains why it is an increasing problem, and what can be done about it.
	11. 24104 Accesses	Question and Answer Q&A: ChIP-seq technologies and the study of gene regulation Edison T Liu, Sebastian Pott, Mikael Huss BMC Biology 2010, 8:56 (14 May 2010) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Edison Liu and colleagues explain in Q&A format how ChIP-seq technology allows investigation of transcriptional regulation on a genomic scale, and what is next.
	12. 23646 Accesses	Question and Answer Q&A: 'Toxic' effects of sugar: should we be afraid of fructose? Luc Tappy BMC Biology 2012, 10:42 (21 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Before the colonial era of sugar plantations we consumed, on average, about 15-fold less fructose than we do today. Luc Tappy explains, in question and answer format, the special features of fructose metabolism and discusses the evidence that high fructose intake has contributed to the current epidemic of obesity and metabolic disease.
	13. 22493 Accesses	Methodology article Modulation of Aβ₄₂low-n oligomerization using a novel yeast reporter system Sviatoslav Bagriantsev, Susan Liebman BMC Biology 2006, 4:32 (26 September 2006) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new yeast model allows investigation of the pathways that regulate the accumulation of toxic amyloid oligomers, the causative agents of Alzheimer's disease, providing a means to interfere with this step in the pathogenic process.
	14. 21746 Accesses	Research article Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet Vincent Corbel, Maria Stankiewicz, Cédric Pennetier, Didier Fournier, Jure Stojan, Emmanuelle Girard, Mitko Dimitrov, Jordi Molgó, Jean-Marc Hougard, Bruno Lapied BMC Biology 2009, 7:47 (5 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Deet, an insect repellent used by 200 million people a year, not only modifies insect behavior but also inhibits cholinesterase in insects and mammals, and interacts with the carbamate insecticides to increase their toxicity.
	15. 21034 Accesses	Research article Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin Jörg M Harms, Frank Schlünzen, Paola Fucini, Heike Bartels, Ada Yonath BMC Biology 2004, 2:4 (1 April 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Analysis of the crystal structure of the Deinococcus radiodurans ribosome reveals how two antibiotics, streptogramin A and B, synergize to inhibit bacterial protein synthesis.
	16. 20969 Accesses	Question and Answer Q&A: Who is H. sapiens really, and how do we know? Mason Liang, Rasmus Nielsen BMC Biology 2011, 9:20 (31 March 2011) Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Modern sequencing technology has made it possible to scavenge the DNA of extinct hominin ancestors for evidence of interbreeding with Homo sapiens. Liang and Nielsen examine the evidence, what it tells us and how sure we can be
	17. 20842 Accesses	Research article The colonization of land by animals: molecular phylogeny and divergence times among arthropods Davide Pisani, Laura L Poling, Maureen Lyons-Weiler, S Hedges BMC Biology 2004, 2:1 (19 January 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An unexpectedly close relationship between myriapods (millipedes, centipedes) and chelicerates (spiders, scorpions, horseshoe crabs) is revealed by a molecular phylogenetic study, which also suggests arthropods adapted to terrestrial environments relatively late in their evolutionary history.
	18. 20142 Accesses	Opinion Wing pathology of white-nose syndrome in bats suggests life-threatening disruption of physiology Paul M Cryan, Carol Meteyer, Justin G Boyles, David S Blehert BMC Biology 2010, 8:135 (11 November 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary WNS, a disease caused by the invasive skin fungus Geomyces destructans, is killing hibernating bats in North America. Cryan, Meteyer, and coauthors propose that disruption of the normal physiological role of the wings during hibernation is key to explaining the mortality of this disease.
	19. 19793 Accesses	Research article Multigene phylogeny of the Mustelidae: Resolving relationships, tempo and biogeographic history of a mammalian adaptive radiation Klaus-Peter Koepfli, Kerry A Deere, Graham J Slater, Colleen Begg, Keith Begg, Lon Grassman, Mauro Lucherini, Geraldine Veron, Robert K Wayne BMC Biology 2008, 6:10 (14 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A multigene phylogeny of the weasel family, the most species-rich family of the Carnivora, provides evidence for two bursts of diversification during the Neogene period that coincide with major environmental changes and speciation events in other vertebrates.
	20. 18908 Accesses	Forum What does the concept of the stem cell niche really mean today? Arthur D Lander, Judith Kimble, Hans Clevers, Elaine Fuchs, Didier Montarras, Margaret Buckingham, Anne L Calof, Andreas Trumpp, Thordur Oskarsson BMC Biology 2012, 10:19 (9 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary How do current researchers view the stem cell niche? Eight experts from different fields provide their perspective, and ask how stem cells evolve in such an environment, launching a new Forum article type within the cross-journal collection on stem cells.
	21. 18410 Accesses	Research article Intensive language training enhances brain plasticity in chronic aphasia Marcus Meinzer, Thomas Elbert, Christian Wienbruch, Daniela Djundja, Gabriela Barthel, Brigitte Rockstroh BMC Biology 2004, 2:20 (25 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The extent of improvement in the language function of chronic aphasics brought about by speech therapy correlates with the magnitude of change in slow wave activity around their brain lesion.
	22. 18319 Accesses	Question and Answer Q&A: What is a pathogen? A question that begs the point Liise-anne Pirofski, Arturo Casadevall BMC Biology 2012, 10:6 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Arturo Casadevall and Liise-anne Pirofski explain in Q&A format the emergent properties of microbial pathogenesis that make the question impossible to answer, and the emergence of new pathogens almost impossible to predict.
	23. 18098 Accesses	Commentary Altered metabolism in cancer Jason W Locasale, Lewis C Cantley BMC Biology 2010, 8:88 (25 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cancer cells have metabolic requirements that differ from those of normal cells. Locasale and Cantley discuss how they reconfigure metabolic pathway fluxes to support cell-autonomous proliferation.
	24. 17878 Accesses	Research article Real-time phase-contrast x-ray imaging: a new technique for the study of animal form and function John J Socha, Mark W Westneat, Jon F Harrison, James S Waters, Wah-Keat Lee BMC Biology 2007, 5:6 (1 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Sophisticated x-ray imaging techniques are revolutionizing the study of the internal workings of small living insects by providing clear visualizations of the internal anatomy in real time whilst minimising harmful effects.
	25. 17584 Accesses	Research article The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications The Rice Chromosomes 11 and 12 Sequencing Consortia* BMC Biology 2005, 3:20 (27 September 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Analysis of the complete sequences of rice chromosomes 11 and 12, comprising 1/7 of the whole genome, identifies nearly 6000 genes, of which more than 5% are involved in disease resistance or defense, a greater proportion than on other chromosomes.