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1.

6522
Accesses

Review   Open Access Highly Accessed

Modeling the within-host dynamics of HIV infection

Alan S Perelson, Ruy M Ribeiro BMC Biology 2013, 11:96 (3 September 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Alan Perelson and Ruy Ribeiro explain how differential equations that model the dynamics of HIV replication in its human host have led to important quantitative insights into the biology of HIV infection.

2.

3522
Accesses

Comment   Open Access Highly Accessed

Open questions: Zombie projects, translational research, and the real secret of the inside of the cell

Gregory A Petsko BMC Biology 2013, 11:97 (2 September 2013)

Abstract | Full text | PDF | 1 comment |  Editor’s summary

Gregory Petsko, writing for the BMC Biology tenth birthday Open questions series, argues, with his usual forthrightness, that we need to pay more attention to where the balance of ‘big’ and ‘little’ science is going, and remember how little we know about the interior of the cell.

3.

2783
Accesses

Interview   Open Access Highly Accessed

From aging worms to the influence of the microbiota: an interview with David Weinkove

David Weinkove BMC Biology 2013, 11:94 (29 August 2013)

Full text | PDF | PubMed |  Editor’s summary

David Weinkove explains, in an interview on his BMC Award-winning paper, how an unlooked-for effect of the common food supplement folate on aging in C. elegans caused him to refocus his research on the E. coli that they feed on.

4.

2642
Accesses

Editorial   Open Access Highly Accessed

Tony Pawson and the germination and flowering of cell signaling: an appreciation

Bruce J Mayer BMC Biology 2013, 11:95 (28 August 2013)

Full text | PDF |  Editor’s summary

The death of Tony Pawson on August 7 was a loss to science and a personal loss to many in his field. Bruce Mayer, in an appreciation of his phenomenal contribution to the understanding of cell signalling, explains how his science grew from the study of  an obscure oncogenic kinase, and why he will be so badly missed.

5.

2516
Accesses

Research article   Open Access Highly Accessed

Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence

Irena Manov, Mark Hirsh, Theodore C Iancu, Assaf Malik, Nick Sotnichenko, Mark Band, Aaron Avivi, Imad Shams BMC Biology 2013, 11:91 (9 August 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Blind mole rats resist cancer induced by chemical carcinogens and their fibroblasts suppress the viability and growth of cancer cell lines.

6.

2246
Accesses

Review   Open Access Highly Accessed

Molecular dynamics simulations and drug discovery

Jacob D Durrant, J Andrew McCammon BMC Biology 2011, 9:71 (28 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | f1000 |  Editor’s summary

Modeling the movements of atoms within macromolecules can predict their conformational flexibility to inform drug discovery. Jacob Durrant and Andrew McCammon explain how this is done in molecular dynamics simulations, reviewing both the successes and current limitations of the approach.

7.

1888
Accesses

Research article   Open Access

Diversity is maintained by seasonal variation in species abundance

Hideyasu Shimadzu, Maria Dornelas, Peter A Henderson, Anne E Magurran BMC Biology 2013, 11:98 (4 September 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A fish population dataset collected over 30 years shows a connection between seasonal resource abundance and the maintenance of species diversity.

8.

1814
Accesses

Comment   Open Access

Low-dose radiation, scientific scrutiny, and requirements for demonstrating effects

Anders Møller, Timothy Mousseau BMC Biology 2013, 11:92 (30 August 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Anders Møller and Timothy Mousseau make a case for more research on chronic radiation exposure, and lay out what they see as the key questions to be answered.

9.

1758
Accesses

Question and Answer   Open Access Highly Accessed

Q&A: What is the Golgi apparatus, and why are we asking?

Sean Munro BMC Biology 2011, 9:63 (30 September 2011)

Full text | PDF | PubMed | 2 comments |  Editor’s summary

Sean Munro explains in Q&A format why the Golgi apparatus remains a gently seething cauldron of controversy more than 120 years after its discovery.

10.

1434
Accesses

Research article   Open Access Highly Accessed

Evolution and diversity of Rickettsia bacteria

Lucy A Weinert, John H Werren, Alexandre Aebi, Graham N Stone, Francis M Jiggins BMC Biology 2009, 7:6 (2 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Twenty new strains of Rickettsia have been identified and although some species cause disease in mammals and can infect protists, they comprise only a few branches of the phylogenetic tree and the bacteria primarily infect arthropods.

11.

1317
Accesses

Research article   Open Access Highly Accessed

Systematics and plastid genome evolution of the cryptically photosynthetic parasitic plant genus Cuscuta (Convolvulaceae)

Joel R McNeal, Kathiravetpilla Arumugunathan, Jennifer V Kuehl, Jeffrey L Boore, Claude W dePamphilis BMC Biology 2007, 5:55 (13 December 2007)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The parasitic plant genus Cuscuta has undergone complex patterns of evolution according to new evidence from DNA sequence data, therefore classifying this unusual group based on morphological or ecological characteristics alone is misleading.

12.

1310
Accesses

Research article   Open Access Highly Accessed

Conditional embryonic lethality to improve the sterile insect technique in Ceratitis capitata (Diptera: Tephritidae)

Marc F Schetelig, Carlos Caceres, Antigone Zacharopoulou, Gerald Franz, Ernst A Wimmer BMC Biology 2009, 7:4 (27 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A novel transgenic lethality system in the male Mediterranean fruit fly Ceratitis capitata results in all progeny dying during embryogenesis, ensuring 100% effective pest control without the need for irradiation.

13.

1271
Accesses

Research article   Open Access

Transcription of a protein-coding gene on B chromosomes of the Siberian roe deer (Capreolus pygargus)

Vladimir A Trifonov, Polina V Dementyeva, Denis M Larkin, Patricia CM O’Brien, Polina L Perelman, Fengtang Yang, Malcolm A Ferguson-Smith, Alexander S Graphodatsky BMC Biology 2013, 11:90 (6 August 2013)

Abstract | Full text | PDF | PubMed

14.

1237
Accesses

Forum   Open Access Highly Accessed

What determines cell size?

Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu, Adrienne HK Roeder BMC Biology 2012, 10:101 (14 December 2012)

Abstract | Full text | PDF | PubMed | 2 comments |  Editor’s summary

In a Forum article in the Cell geometry series, ten experts in ten different systems explain why it matters what size a cell is, and offer ten different answers on how it is controlled – probably all of them right.

15.

1238
Accesses

Review   Open Access Highly Accessed

LKB1 and AMPK and the cancer-metabolism link - ten years after

D Hardie, Dario R Alessi BMC Biology 2013, 11:36 (15 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Ten years ago Grahame Hardie published in Journal of Biology (now BMC Biology) the discovery that the upstream activating kinase he was seeking for the multifarious energy sensor AMPK was the tumor suppressor, LKB1, that Dario Alessi was working on in a neighboring lab. For BMC Biology’s tenth anniversary they review some of what they have discovered since.

16.

1164
Accesses

Opinion   Open Access Highly Accessed

RNAi in the regulation of mammalian viral infections

Kuan-Teh Jeang BMC Biology 2012, 10:58 (26 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Gene silencing by RNA interference is an established antiviral defense in nematodes and fruit flies, but has been widely thought absent - and unnecessary - for mammalian defense against viruses. Kuan-Teh Jeang reviews emerging evidence that RNAi operates against viruses in mammals too.

17.

1062
Accesses

Research article   Open Access

The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota

Widad Dantoft, Monica M Davis, Jessica M Lindvall, Xiongzhuo Tang, Hanna Uvell, Anna Junell, Anne Beskow, Ylva Engström BMC Biology 2013, 11:99 (6 September 2013)

Abstract | Full text | PDF | PubMed

18.

1050
Accesses

Research article   Open Access Highly Accessed

Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations

Hong Shi, Hua Zhong, Yi Peng, Yong-Li Dong, Xue-Bin Qi, Feng Zhang, Lu-Fang Liu, Si-Jie Tan, Runlin Z Ma, Chun-Jie Xiao, R Spencer Wells, Li Jin, Bing Su BMC Biology 2008, 6:45 (29 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Evidence from a newly studied Y-chromosome line suggests that the first northward expansion of humans through East Asia was much earlier than previously believed, as well as multiple independent migrations into Tibet and Japan.

19.

1027
Accesses

Review   Open Access Highly Accessed

Gene regulation by the act of long non-coding RNA transcription

Aleksandra E Kornienko, Philipp M Guenzl, Denise P Barlow, Florian M Pauler BMC Biology 2013, 11:59 (30 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Florian Pauler, Denise Barlow and colleagues review the evidence on long non-protein-coding RNAs for which the process of transcription itself functions in the regulation of nearby genes, but the RNA product may be irrelevant.

20.

988
Accesses

Research article   Open Access

Gene-environment and protein-degradation signatures characterize genomic and phenotypic diversity in wild Caenorhabditis elegans populations

Rita JM Volkers, L Snoek, Caspara J van Hellenberg Hubar, Renata Coopman, Wei Chen, Wentao Yang, Mark G Sterken, Hinrich Schulenburg, Bart P Braeckman, Jan E Kammenga BMC Biology 2013, 11:93 (19 August 2013)

Abstract | Full text | PDF | PubMed

21.

848
Accesses

Research article   Open Access Highly Accessed

The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ

Daniel N Düring, Alexander Ziegler, Christopher K Thompson, Andreas Ziegler, Cornelius Faber, Johannes Müller, Constance Scharff, Coen PH Elemans BMC Biology 2013, 11:1 (8 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The three-dimensional anatomy of the zebra finch vocal organ is described in unprecedented detail, providing new insights into the biomechanics of song production in a species widely used as an experimental model for vocal learning.

22.

838
Accesses

Methodology article   Open Access Highly Accessed

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

Maria Vinci, Sharon Gowan, Frances Boxall, Lisa Patterson, Miriam Zimmermann, William Court, Cara Lomas, Marta Mendiola, David Hardisson, Suzanne A Eccles BMC Biology 2012, 10:29 (22 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A high throughput method to assay for the growth, invasiveness and angiogenic activity of tumor cells grown in 3-dimensions is validated by testing known cancer drugs, and offers a tool-kit for testing new ones.

23.

804
Accesses

Research article   Open Access Highly Accessed

Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements

Morten Rye, Pål Sætrom, Tony Håndstad, Finn Drabløs BMC Biology 2011, 9:80 (24 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

749
Accesses

Opinion   Open Access Highly Accessed

Two patients walk into a clinic...a genomics perspective on the future of schizophrenia

Aiden P Corvin BMC Biology 2011, 9:77 (11 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

How will progress in understanding genetic susceptibility to schizophrenia affect patients? Aiden Corvin suggests that it will not continue to be viewed as a single disease, and that diagnosis and treatment will be transformed.

25.

740
Accesses

Research article   Open Access

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

Daniel H Haft, Malay Basu, Douglas A Mitchell BMC Biology 2010, 8:70 (25 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Mitchell and colleagues describe two new gene families, widespread in bacteria, with features suggesting they encode precursor peptides that are post-translationally modified to generate diverse natural products of potential medical relevance.

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