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	1. 13191 Accesses	Research article scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby BMC Biology 2009, 7:62 (24 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Scribble, a cell polarity regulator in Drosophila, represses tumorigenesis by inhibiting atypical protein kinase C and Jun N-terminal kinase-dependent pathways, and this might be relevant for how human Scrib restrains oncogene-mediated transformation.
	2. 3084 Accesses	Research article Ancient origin of somatic and visceral neurons Marc Nomaksteinsky, Stefan Kassabov, Zoubida Chettouh, Henri-Corto Stoeklé, Laure Bonnaud, Gilles Fortin, Eric R Kandel, Jean-François Brunet BMC Biology 2013, 11:53 (30 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The great American palaeontologist and anatomist Alfred Romer speculated that early in animal life, an emerging somatic nervous system, focused on the outside world, struggled to dominate the visceral nervous system that takes care of the internal systems that keep us alive. Jean-François Brunet and colleagues identify the molecular signatures that tell the evolutionary tale of this duality.
	3. 2564 Accesses	Commentary Somatic and visceral nervous systems - an ancient duality Paola Bertucci, Detlev Arendt BMC Biology 2013, 11:54 (30 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The idea that vertebrates are composed of a ‘visceral’ and ‘somatic’ self, responding to internal and external stimuli, respectively, was first put forward in the 19th century. Now, molecular fingerprinting indicates a duality between the somatic and visceral nervous systems that appears to predate Bilataria.
	4. 2177 Accesses	Review LKB1 and AMPK and the cancer-metabolism link - ten years after D Hardie, Dario R Alessi BMC Biology 2013, 11:36 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ten years ago Grahame Hardie published in Journal of Biology (now BMC Biology) the discovery that the upstream activating kinase he was seeking for the multifarious energy sensor AMPK was the tumor suppressor, LKB1, that Dario Alessi was working on in a neighboring lab. For BMC Biology’s tenth anniversary they review some of what they have discovered since.
	5. 2126 Accesses	Review Molecular dynamics simulations and drug discovery Jacob D Durrant, J Andrew McCammon BMC Biology 2011, 9:71 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Modeling the movements of atoms within macromolecules can predict their conformational flexibility to inform drug discovery. Jacob Durrant and Andrew McCammon explain how this is done in molecular dynamics simulations, reviewing both the successes and current limitations of the approach.
	6. 1861 Accesses	Comment Domesticating the beast Virginia Walbot BMC Biology 2013, 11:35 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In 2009, Virginia Walbot commented ‘Are we training pit bulls to review our manuscripts?’ Revisiting the topic, she asks if we can tame our pit bull reviewers by involving students more in peer review and teaching them to see things from an authors’ perspective and the perspective of the journal that is responsible for making a decision on publication.
	7. 1832 Accesses	Interview An interview with Patrick O Brown on the origins and future of open access Patrick O Brown BMC Biology 2013, 11:33 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In an interview for the BMC Biology tenth anniversary collection, Patrick O Brown excavates his memory for the origins of open access publishing, and finds a vision of the future still to be fulfilled.
	8. 1478 Accesses	Research article Spatial and temporal in vivo analysis of circulating and sessile immune cells in mosquitoes: hemocyte mitosis following infection Jonas G King, Julián F Hillyer BMC Biology 2013, 11:55 (30 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Observations on the number, location, phagocytic activity and cell division of hemocytes in the body cavity of mosquitoes sheds new light on the biology of insect immune system cells.
	9. 1478 Accesses	Question and Answer Q&A: Antibiotic resistance: what more do we know and what more can we do? Gerard D Wright BMC Biology 2013, 11:51 (17 May 2013) Full text \| PDF \| PubMed \| Editor’s summary Antibiotic resistance is both an ancient phenomenon and a worsening medical problem. Gerard Wright explains why, and what should be done about it.
	10. 1373 Accesses	Anniversary Update The new micro-kingdoms of eukaryotes Jan Pawlowski BMC Biology 2013, 11:40 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
	11. 1359 Accesses	Opinion Of flies and men: insights on organismal metabolism from fruit flies Akhila Rajan, Norbert Perrimon BMC Biology 2013, 11:38 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary For many reasons metabolism is now a high-profile topic, and in an update to mark the tenth anniversary of BMC Biology, Norbert Perrimon and Akhila Rajan review the remarkable similarities that make Drosophila a model for mammalian metabolism, and some recent advances made possible by the advantages of this model organism.
	12. 1351 Accesses	Anniversary Update White-nose syndrome in bats: illuminating the darkness Paul M Cryan, Carol Meteyer, Justin G Boyles, David S Blehert BMC Biology 2013, 11:47 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
	13. 1353 Accesses	Question and Answer Q&A: What is the Golgi apparatus, and why are we asking? Sean Munro BMC Biology 2011, 9:63 (30 September 2011) Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary Sean Munro explains in Q&A format why the Golgi apparatus remains a gently seething cauldron of controversy more than 120 years after its discovery.
	14. 1310 Accesses	Research article Statistical support for the hypothesis of developmental constraint in marsupial skull evolution C Verity Bennett, Anjali Goswami BMC Biology 2013, 11:52 (26 April 2013) Abstract \| Full text \| PDF \| PubMed
	15. 1235 Accesses	Anniversary Update Seeing the Tree of Life behind the phylogenetic forest Pere Puigbò, Yuri I Wolf, Eugene V Koonin BMC Biology 2013, 11:46 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
	16. 1226 Accesses	Commentary Mitochondrial genomes as living ‘fossils’ Ian Small BMC Biology 2013, 11:30 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ian Small discusses why the "fossilised" mitochondrial genome of Liriodendron could have such a slow mutation rate, and what it might tell us about the evolution of RNA editing.
	17. 1178 Accesses	Research article On the origin of POU5F1 Stephen Frankenberg, Marilyn B Renfree BMC Biology 2013, 11:56 (9 May 2013) Abstract \| Provisional PDF \| PubMed
	18. 1159 Accesses	Review Microarrays, deep sequencing and the true measure of the transcriptome John H Malone, Brian Oliver BMC Biology 2011, 9:34 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Global measures of gene expression can now be extracted either from microarrays or from RNA-seq, which do not always seem to give the same answer. Malone and Oliver review the advantages and limitations of each and conclude that, with some important exceptions, they tell the same story.
	19. 1144 Accesses	Research article The “fossilized” mitochondrial genome of Liriodendron tulipifera: ancestral gene content and order, ancestral editing sites, and extraordinarily low mutation rate Aaron O Richardson, Danny W Rice, Gregory J Young, Andrew J Alverson, Jeffrey D Palmer BMC Biology 2013, 11:29 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The mitochondrial genome of the tulip tree has a remarkably slow rate of nucleotide substitution, and could offer insight into the content and organisation of this genome in the ancestral flowering plant.
	20. 1114 Accesses	Anniversary Update Arthropods and inherited bacteria: from counting the symbionts to understanding how symbionts count Olivier Duron, Gregory DD Hurst BMC Biology 2013, 11:45 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
	21. 1059 Accesses	Research article Radial glial cells play a key role in echinoderm neural regeneration Vladimir S Mashanov, Olga R Zueva, José E García-Arrarás BMC Biology 2013, 11:49 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Repair of a cut radial nerve cord in a sea cucumber is mediated by radial glial cells that dedifferentiate, divide and give rise to new neurons.
	22. 1024 Accesses	Forum What determines cell size? Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu, Adrienne HK Roeder BMC Biology 2012, 10:101 (14 December 2012) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary In a Forum article in the Cell geometry series, ten experts in ten different systems explain why it matters what size a cell is, and offer ten different answers on how it is controlled – probably all of them right.
	23. 976 Accesses	Review Drugging Hedgehog: signaling the pathway to translation Tom J Carney, Philip W Ingham BMC Biology 2013, 11:37 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ten years ago Jeff Porter and colleagues published a screen for small-molecule modulators of the Hedgehog signaling pathway in the Journal of Biology. For BMC Biology’s 10^th anniversary, Tom Carney and Philip Ingham discuss the far-reaching clinical impact of some of the agonists and antagonists they discovered.
	24. 890 Accesses	Research article Control of the olive fruit fly using genetics-enhanced sterile insect technique Thomas Ant, Martha Koukidou, Polychronis Rempoulakis, Hong-Fei Gong, Aris Economopoulos, John Vontas, Luke Alphey BMC Biology 2012, 10:51 (19 June 2012) Abstract \| Full text \| PDF \| PubMed
	25. 878 Accesses	Research article Conditional embryonic lethality to improve the sterile insect technique in Ceratitis capitata (Diptera: Tephritidae) Marc F Schetelig, Carlos Caceres, Antigone Zacharopoulou, Gerald Franz, Ernst A Wimmer BMC Biology 2009, 7:4 (27 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel transgenic lethality system in the male Mediterranean fruit fly Ceratitis capitata results in all progeny dying during embryogenesis, ensuring 100% effective pest control without the need for irradiation.