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	1. 6522 Accesses	Review Modeling the within-host dynamics of HIV infection Alan S Perelson, Ruy M Ribeiro BMC Biology 2013, 11:96 (3 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alan Perelson and Ruy Ribeiro explain how differential equations that model the dynamics of HIV replication in its human host have led to important quantitative insights into the biology of HIV infection.
	2. 3522 Accesses	Comment Open questions: Zombie projects, translational research, and the real secret of the inside of the cell Gregory A Petsko BMC Biology 2013, 11:97 (2 September 2013) Abstract \| Full text \| PDF \| 1 comment \| Editor’s summary Gregory Petsko, writing for the BMC Biology tenth birthday Open questions series, argues, with his usual forthrightness, that we need to pay more attention to where the balance of ‘big’ and ‘little’ science is going, and remember how little we know about the interior of the cell.
	3. 2783 Accesses	Interview From aging worms to the influence of the microbiota: an interview with David Weinkove David Weinkove BMC Biology 2013, 11:94 (29 August 2013) Full text \| PDF \| PubMed \| Editor’s summary David Weinkove explains, in an interview on his BMC Award-winning paper, how an unlooked-for effect of the common food supplement folate on aging in C. elegans caused him to refocus his research on the E. coli that they feed on.
	4. 2642 Accesses	Editorial Tony Pawson and the germination and flowering of cell signaling: an appreciation Bruce J Mayer BMC Biology 2013, 11:95 (28 August 2013) Full text \| PDF \| Editor’s summary The death of Tony Pawson on August 7 was a loss to science and a personal loss to many in his field. Bruce Mayer, in an appreciation of his phenomenal contribution to the understanding of cell signalling, explains how his science grew from the study of an obscure oncogenic kinase, and why he will be so badly missed.
	5. 2516 Accesses	Research article Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence Irena Manov, Mark Hirsh, Theodore C Iancu, Assaf Malik, Nick Sotnichenko, Mark Band, Aaron Avivi, Imad Shams BMC Biology 2013, 11:91 (9 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Blind mole rats resist cancer induced by chemical carcinogens and their fibroblasts suppress the viability and growth of cancer cell lines.
	6. 2246 Accesses	Review Molecular dynamics simulations and drug discovery Jacob D Durrant, J Andrew McCammon BMC Biology 2011, 9:71 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| f1000 \| Editor’s summary Modeling the movements of atoms within macromolecules can predict their conformational flexibility to inform drug discovery. Jacob Durrant and Andrew McCammon explain how this is done in molecular dynamics simulations, reviewing both the successes and current limitations of the approach.
	7. 1888 Accesses	Research article Diversity is maintained by seasonal variation in species abundance Hideyasu Shimadzu, Maria Dornelas, Peter A Henderson, Anne E Magurran BMC Biology 2013, 11:98 (4 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A fish population dataset collected over 30 years shows a connection between seasonal resource abundance and the maintenance of species diversity.
	8. 1814 Accesses	Comment Low-dose radiation, scientific scrutiny, and requirements for demonstrating effects Anders Møller, Timothy Mousseau BMC Biology 2013, 11:92 (30 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Anders Møller and Timothy Mousseau make a case for more research on chronic radiation exposure, and lay out what they see as the key questions to be answered.
	9. 1758 Accesses	Question and Answer Q&A: What is the Golgi apparatus, and why are we asking? Sean Munro BMC Biology 2011, 9:63 (30 September 2011) Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary Sean Munro explains in Q&A format why the Golgi apparatus remains a gently seething cauldron of controversy more than 120 years after its discovery.
	10. 1434 Accesses	Research article Evolution and diversity of Rickettsia bacteria Lucy A Weinert, John H Werren, Alexandre Aebi, Graham N Stone, Francis M Jiggins BMC Biology 2009, 7:6 (2 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Twenty new strains of Rickettsia have been identified and although some species cause disease in mammals and can infect protists, they comprise only a few branches of the phylogenetic tree and the bacteria primarily infect arthropods.
	11. 1317 Accesses	Research article Systematics and plastid genome evolution of the cryptically photosynthetic parasitic plant genus Cuscuta (Convolvulaceae) Joel R McNeal, Kathiravetpilla Arumugunathan, Jennifer V Kuehl, Jeffrey L Boore, Claude W dePamphilis BMC Biology 2007, 5:55 (13 December 2007) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The parasitic plant genus Cuscuta has undergone complex patterns of evolution according to new evidence from DNA sequence data, therefore classifying this unusual group based on morphological or ecological characteristics alone is misleading.
	12. 1310 Accesses	Research article Conditional embryonic lethality to improve the sterile insect technique in Ceratitis capitata (Diptera: Tephritidae) Marc F Schetelig, Carlos Caceres, Antigone Zacharopoulou, Gerald Franz, Ernst A Wimmer BMC Biology 2009, 7:4 (27 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel transgenic lethality system in the male Mediterranean fruit fly Ceratitis capitata results in all progeny dying during embryogenesis, ensuring 100% effective pest control without the need for irradiation.
	13. 1271 Accesses	Research article Transcription of a protein-coding gene on B chromosomes of the Siberian roe deer (Capreolus pygargus) Vladimir A Trifonov, Polina V Dementyeva, Denis M Larkin, Patricia CM O’Brien, Polina L Perelman, Fengtang Yang, Malcolm A Ferguson-Smith, Alexander S Graphodatsky BMC Biology 2013, 11:90 (6 August 2013) Abstract \| Full text \| PDF \| PubMed
	14. 1237 Accesses	Forum What determines cell size? Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu, Adrienne HK Roeder BMC Biology 2012, 10:101 (14 December 2012) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary In a Forum article in the Cell geometry series, ten experts in ten different systems explain why it matters what size a cell is, and offer ten different answers on how it is controlled – probably all of them right.
	15. 1238 Accesses	Review LKB1 and AMPK and the cancer-metabolism link - ten years after D Hardie, Dario R Alessi BMC Biology 2013, 11:36 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ten years ago Grahame Hardie published in Journal of Biology (now BMC Biology) the discovery that the upstream activating kinase he was seeking for the multifarious energy sensor AMPK was the tumor suppressor, LKB1, that Dario Alessi was working on in a neighboring lab. For BMC Biology’s tenth anniversary they review some of what they have discovered since.
	16. 1164 Accesses	Opinion RNAi in the regulation of mammalian viral infections Kuan-Teh Jeang BMC Biology 2012, 10:58 (26 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gene silencing by RNA interference is an established antiviral defense in nematodes and fruit flies, but has been widely thought absent - and unnecessary - for mammalian defense against viruses. Kuan-Teh Jeang reviews emerging evidence that RNAi operates against viruses in mammals too.
	17. 1062 Accesses	Research article The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota Widad Dantoft, Monica M Davis, Jessica M Lindvall, Xiongzhuo Tang, Hanna Uvell, Anna Junell, Anne Beskow, Ylva Engström BMC Biology 2013, 11:99 (6 September 2013) Abstract \| Full text \| PDF \| PubMed
	18. 1050 Accesses	Research article Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations Hong Shi, Hua Zhong, Yi Peng, Yong-Li Dong, Xue-Bin Qi, Feng Zhang, Lu-Fang Liu, Si-Jie Tan, Runlin Z Ma, Chun-Jie Xiao, R Spencer Wells, Li Jin, Bing Su BMC Biology 2008, 6:45 (29 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Evidence from a newly studied Y-chromosome line suggests that the first northward expansion of humans through East Asia was much earlier than previously believed, as well as multiple independent migrations into Tibet and Japan.
	19. 1027 Accesses	Review Gene regulation by the act of long non-coding RNA transcription Aleksandra E Kornienko, Philipp M Guenzl, Denise P Barlow, Florian M Pauler BMC Biology 2013, 11:59 (30 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Florian Pauler, Denise Barlow and colleagues review the evidence on long non-protein-coding RNAs for which the process of transcription itself functions in the regulation of nearby genes, but the RNA product may be irrelevant.
	20. 988 Accesses	Research article Gene-environment and protein-degradation signatures characterize genomic and phenotypic diversity in wild Caenorhabditis elegans populations Rita JM Volkers, L Snoek, Caspara J van Hellenberg Hubar, Renata Coopman, Wei Chen, Wentao Yang, Mark G Sterken, Hinrich Schulenburg, Bart P Braeckman, Jan E Kammenga BMC Biology 2013, 11:93 (19 August 2013) Abstract \| Full text \| PDF \| PubMed
	21. 848 Accesses	Research article The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ Daniel N Düring, Alexander Ziegler, Christopher K Thompson, Andreas Ziegler, Cornelius Faber, Johannes Müller, Constance Scharff, Coen PH Elemans BMC Biology 2013, 11:1 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The three-dimensional anatomy of the zebra finch vocal organ is described in unprecedented detail, providing new insights into the biomechanics of song production in a species widely used as an experimental model for vocal learning.
	22. 838 Accesses	Methodology article Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation Maria Vinci, Sharon Gowan, Frances Boxall, Lisa Patterson, Miriam Zimmermann, William Court, Cara Lomas, Marta Mendiola, David Hardisson, Suzanne A Eccles BMC Biology 2012, 10:29 (22 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A high throughput method to assay for the growth, invasiveness and angiogenic activity of tumor cells grown in 3-dimensions is validated by testing known cancer drugs, and offers a tool-kit for testing new ones.
	23. 804 Accesses	Research article Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements Morten Rye, Pål Sætrom, Tony Håndstad, Finn Drabløs BMC Biology 2011, 9:80 (24 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	24. 749 Accesses	Opinion Two patients walk into a clinic...a genomics perspective on the future of schizophrenia Aiden P Corvin BMC Biology 2011, 9:77 (11 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary How will progress in understanding genetic susceptibility to schizophrenia affect patients? Aiden Corvin suggests that it will not continue to be viewed as a single disease, and that diagnosis and treatment will be transformed.
	25. 740 Accesses	Research article Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family Daniel H Haft, Malay Basu, Douglas A Mitchell BMC Biology 2010, 8:70 (25 May 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mitchell and colleagues describe two new gene families, widespread in bacteria, with features suggesting they encode precursor peptides that are post-translationally modified to generate diverse natural products of potential medical relevance.