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	1. 11173 Accesses	Research article scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby BMC Biology 2009, 7:62 (24 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Scribble, a cell polarity regulator in Drosophila, represses tumorigenesis by inhibiting atypical protein kinase C and Jun N-terminal kinase-dependent pathways, and this might be relevant for how human Scrib restrains oncogene-mediated transformation.
	2. 2833 Accesses	Commentary Predicting the evolution of antibiotic resistance Martijn F Schenk, J Arjan GM de Visser BMC Biology 2013, 11:14 (22 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on research in BMC Evolutionary Biology, Arjan de Visser and Martijn Schenk discuss how two genetic properties, pleiotropy and epistasis, might help us to predict the evolution of antibiotic resistance.
	3. 2595 Accesses	Comment Open questions: Chromosome condensation - Why does a chromosome look like a chromosome? Frank Uhlmann BMC Biology 2013, 11:9 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In his contribution to the ‘Open questions’ anniversary collection for BMC Biology, Frank Uhlmann poses the unsolved problem of chromosome packaging
	4. 2541 Accesses	Editorial Open questions in biology - a tenth anniversary series Miranda Robertson BMC Biology 2013, 11:7 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary To celebrate its tenth anniversary, BMC Biology asked its Editorial Board members to write a paragraph or two on their favorite open questions in biology, and this month it publishes the first contributions, on topics from the challenges of proteomics to the mechanisms of apoptosis.
	5. 2519 Accesses	Review Molecular dynamics simulations and drug discovery Jacob D Durrant, J Andrew McCammon BMC Biology 2011, 9:71 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Modeling the movements of atoms within macromolecules can predict their conformational flexibility to inform drug discovery. Jacob Durrant and Andrew McCammon explain how this is done in molecular dynamics simulations, reviewing both the successes and current limitations of the approach.
	6. 2211 Accesses	Methodology article Multi-channel acoustic recording and automated analysis of Drosophila courtship songs Benjamin J Arthur, Tomoko Sunayama-Morita, Philip Coen, Mala Murthy, David L. Stern BMC Biology 2013, 11:11 (31 January 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Drosophila fruit flies' "singing" during courtship is a model system for both genetic and neural control of behaviour. A newly-designed recording system allows for analysis of the songs' various rhythms and cycles in unprecedented detail.
	7. 2040 Accesses	Research article The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ Daniel N Düring, Alexander Ziegler, Christopher K Thompson, Andreas Ziegler, Cornelius Faber, Johannes Müller, Constance Scharff, Coen PH Elemans BMC Biology 2013, 11:1 (8 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The three-dimensional anatomy of the zebra finch vocal organ is described in unprecedented detail, providing new insights into the biomechanics of song production in a species widely used as an experimental model for vocal learning.
	8. 1864 Accesses	Comment Open questions - in brief: Beyond -omics, missing motor proteins, and getting from molecules to organisms Stephen J Benkovic, Julie Theriot, Dagmar Ringe BMC Biology 2013, 11:8 (31 January 2013) Abstract \| Full text \| PDF \| PubMed
	9. 1850 Accesses	Comment Open questions: missing pieces from the immunological jigsaw puzzle Gillian M Griffiths BMC Biology 2013, 11:10 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gillian Griffiths, in her ‘Open questions’ contribution for BMC Biology, pinpoints some critical missing links in the cell-biological specializations of immune cells
	10. 1652 Accesses	Review Microarrays, deep sequencing and the true measure of the transcriptome John H Malone, Brian Oliver BMC Biology 2011, 9:34 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Global measures of gene expression can now be extracted either from microarrays or from RNA-seq, which do not always seem to give the same answer. Malone and Oliver review the advantages and limitations of each and conclude that, with some important exceptions, they tell the same story.
	11. 1610 Accesses	Question and Answer Q&A: What is the Golgi apparatus, and why are we asking? Sean Munro BMC Biology 2011, 9:63 (30 September 2011) Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary Sean Munro explains in Q&A format why the Golgi apparatus remains a gently seething cauldron of controversy more than 120 years after its discovery.
	12. 1588 Accesses	Research article Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish Masato Yoshizawa, Yoshiyuki Yamamoto, Kelly E O'Quin, William R Jeffery BMC Biology 2012, 10:108 (27 December 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The evolutionary loss of eyes is a process repeated in different cavefish populations, and both neutral and adaptive explanations have been put forward. A study of genetic linkage in an Astyanax population suggests that an antagonostic relationship between eye development and sensors for detecting vibration - an important behaviour in the dark cave environment - is responsible.
	13. 1589 Accesses	Research article Single-copy nuclear genes resolve the phylogeny of the holometabolous insects Brian M Wiegmann, Michelle D Trautwein, Jung-Wook Kim, Brian K Cassel, Matthew A Bertone, Shaun L Winterton, David K Yeates BMC Biology 2009, 7:34 (24 June 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Twisted wing parasites (Strepsiptera), an enigmatic order of insects that has posed a long-standing riddle for taxonomists, are closely related to beetles according to a new phylogeny of holometabolous insects based on six nuclear genes.
	14. 1513 Accesses	Research article Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa Tomislav Domazet-Lošo, Diethard Tautz BMC Biology 2010, 8:66 (21 May 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The origins of genes mutated in cancer can be traced to two pivotal points - growth-controlling "gatekeeper" genes emerge together with multicellular organisms, while "caretaker" genes that safeguard genome stability originate with the evolution of the first cell.
	15. 1341 Accesses	Research article MST1, a key player, in enhancing fast skeletal muscle atrophy Bin Wei, Wen Dui, Dong Liu, Yan Xing, Zengqqiang Yuan, Guangju Ji BMC Biology 2013, 11:12 (1 February 2013) Abstract \| Provisional PDF \| PubMed
	16. 1266 Accesses	Research article Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans Rajarshi Ghosh, Aylia Mohammadi, Leonid Kruglyak, William S Ryu BMC Biology 2012, 10:85 (31 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary By developing a novel assay to quantitate C elegans thermal avoidance behavior, William Ryu and colleagues discovered that different genes are utilized to provide the same phenotypic response, depending on the severity of the applied stimulus.
	17. 1210 Accesses	Research article Modeling the epidemiological history of plague in Central Asia: Palaeoclimatic forcing on a disease system over the past millennium Kyrre Kausrud, Mike Begon, Tamara Ari, Hildegunn Viljugrein, Jan Esper, Ulf Büntgen, Herwig Leirs, Claudia Junge, Bao Yang, Meixue Yang, Lei Xu, Nils Stenseth BMC Biology 2010, 8:112 (27 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Plague pandemics through history may be linked to changes in climate, according to a new analysis in BMC Biology.
	18. 1194 Accesses	Commentary Role of aerobic glycolysis in genetically engineered mouse models of cancer Chi V Dang BMC Biology 2013, 11:3 (23 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Chi Van Dang gives his perspective on research published in the newly launched Cancer and Metabolism suggesting a new target for intervention in the aerobic glycolysis that supports tumor development.
	19. 1126 Accesses	Research article Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles Jingxia Xu, Thomas Gridley BMC Biology 2013, 11:13 (13 February 2013) Abstract \| Provisional PDF \| PubMed
	20. 1114 Accesses	Forum What determines cell size? Wallace F Marshall, Kevin D Young, Matthew Swaffer, Elizabeth Wood, Paul Nurse, Akatsuki Kimura, Joseph Frankel, John Wallingford, Virginia Walbot, Xian Qu, Adrienne HK Roeder BMC Biology 2012, 10:101 (14 December 2012) Abstract \| Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary In a Forum article in the Cell geometry series, ten experts in ten different systems explain why it matters what size a cell is, and offer ten different answers on how it is controlled – probably all of them right.
	21. 1043 Accesses	Question and Answer Q&A: 'Toxic' effects of sugar: should we be afraid of fructose? Luc Tappy BMC Biology 2012, 10:42 (21 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Before the colonial era of sugar plantations we consumed, on average, about 15-fold less fructose than we do today. Luc Tappy explains, in question and answer format, the special features of fructose metabolism and discusses the evidence that high fructose intake has contributed to the current epidemic of obesity and metabolic disease.
	22. 996 Accesses	Question and Answer Q&A: What is a pathogen? A question that begs the point Liise-anne Pirofski, Arturo Casadevall BMC Biology 2012, 10:6 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Arturo Casadevall and Liise-anne Pirofski explain in Q&A format the emergent properties of microbial pathogenesis that make the question impossible to answer, and the emergence of new pathogens almost impossible to predict.
	23. 979 Accesses	Commentary Trade-offs in cavefish sensory capacity Helen Gunter, Axel Meyer BMC Biology 2013, 11:5 (24 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gunter and Meyer, commenting on recent research on cavefish eye evolution, explain how new interdisciplinary approaches can lead to fresh insight into old evolutionary questions.
	24. 952 Accesses	Research article Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour Sarah A Roberts, Deborah M Simpson, Stuart D Armstrong, Amanda J Davidson, Duncan H Robertson, Lynn McLean, Robert J Beynon, Jane L Hurst BMC Biology 2010, 8:75 (3 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Jane Hurst and colleagues have identified a male specific signalling protein, 'darcin', in mouse urine that attracts females and is responsible for learned preference for specific males.
	25. 943 Accesses	Forum What does the concept of the stem cell niche really mean today? Arthur D Lander, Judith Kimble, Hans Clevers, Elaine Fuchs, Didier Montarras, Margaret Buckingham, Anne L Calof, Andreas Trumpp, Thordur Oskarsson BMC Biology 2012, 10:19 (9 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary How do current researchers view the stem cell niche? Eight experts from different fields provide their perspective, and ask how stem cells evolve in such an environment, launching a new Forum article type within the cross-journal collection on stem cells.