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Research article   Open Access

Quality prevails over identity in the sexually selected vocalisations of an ageing mammal

Elodie Briefer, Elisabetta Vannoni, Alan G McElligott BMC Biology 2010, 8:35 (9 April 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The calls of male fallow deer enable individual recognition and are indicative of male quality but over time their acoustic structure is affected by age and dominance rank and become more reliable cues of male quality than individuality.

Commentary   Open Access

Adherens junctions remain dynamic

Matthias M Falk BMC Biology 2010, 8:34 (8 April 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Matthias Falk comments on a new type of adherens junction reported in BMC Biology, explaining how its provision of a dynamic connection between the stress fibers of neighboring endothelial cells adds to our evolving view of the versatility of this class of cell-cell junction.

Research article   Open Access

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy

Francesca Froldi, Marcello Ziosi, Flavio Garoia, Andrea Pession, Nicola A Grzeschik, Paola Bellosta, Dennis Strand, Helena E Richardson, Annalisa Pession, Daniela Grifoni BMC Biology 2010, 8:33 (7 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In Drosophila, loss of the conserved junctional protein ‘lethal giant large’ results in abnormal growth and impaired dMyc expression, eventually leading to cell death through cell competition, suggesting that dMyc oncoprotein is required to promote invasive overgrowth.

Commentary   Open Access Highly Accessed

Anaerobic animals from an ancient, anoxic ecological niche

Marek Mentel, William Martin BMC Biology 2010, 8:32 (6 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Marek Mentel and William Martin argue that the tiny anoxic animals reported by Danovaro et al, with their hydrogenosome-like organelles, are relevant to metazoan evolution before the rise of deep marine oxygen levels, about 550-600 million years ago.

Commentary   Open Access Highly Accessed

Anaerobic Metazoans: No longer an oxymoron

Lisa A Levin BMC Biology 2010, 8:31 (6 April 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Lisa Levin discusses how the three new species of Loricifera reported by Danovaro et al. add a new dimension to the community of unicellular organisms that live in anoxic ocean ecosystems.

Research article   Open Access Highly Accessed

The first metazoa living in permanently anoxic conditions

Roberto Danovaro, Antonio Dell'Anno, Antonio Pusceddu, Cristina Gambi, Iben Heiner, Reinhardt Møbjerg Kristensen BMC Biology 2010, 8:30 (6 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments | F1000 Biology |  Editor’s summary

An expedition to a deep sea hypersaline anoxic basin in the Mediterranean has discovered the first multicellular animals that live and reproduce in the absence of oxygen.

Research article   Open Access

Gene duplication and fragmentation in the zebra finch major histocompatibility complex

Christopher N Balakrishnan, Robert Ekblom, Martin Völker, Helena Westerdahl, Ricardo Godinez, Holly Kotkiewicz, David W Burt, Tina Graves, Darren K Griffin, Wesley C Warren, Scott V Edwards BMC Biology 2010, 8:29 (1 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Zebra finch possesses a more complex major histocompatibility complex (MHC) from that of other birds, which is probably the result of genomic changes such as gene duplication, pseudogenization and the distribution of MHC genes on multiple chromosomes.

Research article   Open Access

The zebra finch neuropeptidome: prediction, detection and expression

Fang Xie, Sarah E London, Bruce R Southey, Suresh P Annangudi, Andinet Amare, Sandra L Rodriguez-Zas, David F Clayton, Jonathan V Sweedler BMC Biology 2010, 8:28 (1 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Characterization of neuropeptides and prohormones in the zebra finch reveals detailed knowledge of the components involved in song recognition learning and provides a basis for future studies investigating the neural mechanisms underlying vocal communication and behavior.

Research article   Open Access

In vivo trans-specific gene silencing in fungal cells by in planta expression of a double-stranded RNA

Maria Tinoco, Bárbara BA Dias, Rebeca C Dall'Astta, João A Pamphile, Francisco JL Aragão BMC Biology 2010, 8:27 (31 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Tobacco plants expressing small interfering RNAs, corresponding to a particular transgene in a fungal pathogen, can effectively silence the fungal gene upon infection suggesting a novel strategy for the development of broad fungi-resistance in plants.

Research article   Open Access

Molecular evidence for increased regulatory conservation during metamorphosis, and against deleterious cascading effects of hybrid breakdown in Drosophila

Carlo G Artieri, Rama S Singh BMC Biology 2010, 8:26 (31 March 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Patterns of gene expression in species and hybrids of Drosophila are more conserved during the pupal stage as compared to earlier or later stages providing support for a 'developmental hourglass' model of divergence of gene expression.

Research article   Open Access Highly Accessed

To signal or not to signal? Chemical communication by urine-borne signals mirrors sexual conflict in crayfish

Fiona C Berry, Thomas Breithaupt BMC Biology 2010, 8:25 (30 March 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Urine signaling is associated with aggressive behavior in both sexes of crayfish, but during reproductive encounters, chemicals in female urine stimulate males to switch to a courtship behavior and favor mating success.

Research article   Open Access

Denitrification in human dental plaque

Frank Schreiber, Peter Stief, Armin Gieseke, Ines M Heisterkamp, Willy Verstraete, Dirk de Beer, Paul Stoodley BMC Biology 2010, 8:24 (22 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The formation of gaseous nitric oxide from microbial nitrate reduction in dental plaque can potentially affect normal gum physiology and may therefore be as relevant as aerobic respiration and acid fermentation for understanding periodontal disease.

Research article   Open Access

ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function

Sanghoon Kwon, Dongbum Kim, Jae Rhee, Jeong-A Park, Dae-Won Kim, Doo-Sik Kim, Younghee Lee, Hyung-Joo Kwon BMC Biology 2010, 8:23 (19 March 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein ASB9 interacts with the mitochondrial creatine kinase, via the SOCS domain, and is crucial for regulating growth of human cells.

Research article   Open Access

Geographic and ecologic heterogeneity in elimination thresholds for the major vector-borne helminthic disease, lymphatic filariasis

Manoj Gambhir, Moses Bockarie, Daniel Tisch, James Kazura, Justin Remais, Robert Spear, Edwin Michael BMC Biology 2010, 8:22 (17 March 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Variation in key local factors such as ecological conditions and acquired immunity affecting transmission of the filarial nematode worm that causes lymphatic filariasis or 'elephantiasis' can lead to significant uncertainty in predicting elimination thresholds of this tropical disease.

Correspondence   Open Access

A New Replicator: A theoretical framework for analysing replication

István Zachar, Eörs Szathmáry BMC Biology 2010, 8:21 (10 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Zachar and Szathmáry redefine the concept of a 'replicator' in evolution as an autocatalytic entity which is dependent on a specific working environment and the selective forces acting on it.

Commentary   Open Access

Unraveling the mysteries of dog evolution

Rodney L Honeycutt BMC Biology 2010, 8:20 (9 March 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Rodney Honeycutt discusses the findings of a recent study by Robert Wayne and colleagues (BMC Biology 2010, 8:16), on the use of novel genetic markers to investigate the origin and diversification of the domestic dog.

Correspondence   Open Access

Rapid progress on the vertebrate tree of life

Robert C Thomson, H Bradley Shaffer BMC Biology 2010, 8:19 (8 March 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Progress towards completing the vertebrate 'tree of life' has been rapid but also skewed, with birds and mammals receiving most attention and marine organisms accumulating far fewer data than terrestrial groups.

Methodology article   Open Access

Monitoring the regulation of gene expression in a growing organ using a fluid mechanics formalism

Rémy Merret, Bruno Moulia, Irène Hummel, David Cohen, Erwin Dreyer, Marie-Béatrice Bogeat-Triboulot BMC Biology 2010, 8:18 (4 March 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Simultaneously studying growth rates and gene expression in plant development has resulted in a new mechanistic modeling approach to quantify rates of change in a moving and expanding cell or organ.

Research article   Open Access

Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform

Mohammad G Sabbir, Nichola Wigle, Shauna Loewen, Yuan Gu, Cordula Buse, Geoffrey G Hicks, Michael RA Mowat BMC Biology 2010, 8:17 (3 March 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Embryonic development fails in mice deficient in a single isoform of the tumour suppressor Dlc1, with defects in brain, heart and placental blood vessels indicating an essential in vivo role for this Rho GTPase activating protein.

Research article   Open Access Highly Accessed

The IGF1 small dog haplotype is derived from Middle Eastern grey wolves

Melissa M Gray, Nathan B Sutter, Elaine A Ostrander, Robert K Wayne BMC Biology 2010, 8:16 (24 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Genetic variation in and around the insulin-like growth factor 1 gene defines a small dog haplotype, which appears to have arisen soon after domestication, and to have originated from Middle Eastern gray wolves.

Research article   Open Access Highly Accessed

Evidence that a West-East admixed population lived in the Tarim Basin as early as the early Bronze Age

Chunxiang Li, Hongjie Li, Yinqiu Cui, Chengzhi Xie, Dawei Cai, Wenying Li, Victor H Mair, Zhi Xu, Quanchao Zhang, Idelisi Abuduresule, Li Jin, Hong Zhu, Hui Zhou BMC Biology 2010, 8:15 (17 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Genetic analysis of human remains from the Tarim Basin in China reveals that the Xiaohe people comprised an admixture of populations originating from both the East and the West dating from the early Bronze Age.

Research article   Open Access Highly Accessed

A metabolic signature of long life in Caenorhabditis elegans

Silke Fuchs, Jacob G Bundy, Sarah K Davies, Jonathan M Viney, Jonathan S Swire, Armand M Leroi BMC Biology 2010, 8:14 (10 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Upregulation of gluconeogenesis and the glyoxylate shunt, as well as changes in amino acid catabolism, are metabolic responses that are common to different long-lived mutants of Caenorhabditis elegans.

Research article   Open Access

Stone formation in peach fruit exhibits spatial coordination of the lignin and flavonoid pathways and similarity to Arabidopsis dehiscence

Christopher D Dardick, Ann M Callahan, Remo Chiozzotto, Robert J Schaffer, M Claudia Piagnani, Ralph Scorza BMC Biology 2010, 8:13 (9 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Endocarp development in peach involves lignification in concert with a separate induction of the competing flavonoid pathway, and is regulated by transcription factors previously shown to govern the analagous process in Arabidopsis.

Research article   Open Access

Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families

Robert Kammerer, Wolfgang Zimmermann BMC Biology 2010, 8:12 (4 February 2010)

Abstract | Full text | PDF | PubMed | F1000 |  Editor’s summary

The high evolutionary diversity of carcinoembryonic antigen (CEA) families in mammals could be a result of their involvement in fetal-maternal conflict processes and the pressure exerted by different pathogens binding to CEA receptors.

Research article   Open Access

Adherens junctions connect stress fibres between adjacent endothelial cells

Jaime Millán, Robert J Cain, Natalia Reglero-Real, Carolina Bigarella, Beatriz Marcos-Ramiro, Laura Fernández-Martín, Isabel Correas, Anne J Ridley BMC Biology 2010, 8:11 (2 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Adherens junction proteins connecting adjacent endothelial cells attach to the ends of actin stress fibers rather than cortical F-actin, forming dynamic structures that bridge cells at discontinuous sites of contact.

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