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Volume 11 (2013) - January 2013

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Methodology article   Open Access

Multi-channel acoustic recording and automated analysis of Drosophila courtship songs

Benjamin J Arthur, Tomoko Sunayama-Morita, Philip Coen, Mala Murthy, David L. Stern BMC Biology 2013, 11:11 (31 January 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Drosophila fruit flies' "singing" during courtship is a model system for both genetic and neural control of behaviour. A newly-designed recording system allows for analysis of the songs' various rhythms and cycles in unprecedented detail.

Comment   Open Access

Open questions: missing pieces from the immunological jigsaw puzzle

Gillian M Griffiths BMC Biology 2013, 11:10 (31 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Gillian Griffiths, in her ‘Open questions’ contribution for BMC Biology, pinpoints some critical missing links in the cell-biological specializations of immune cells

Comment   Open Access

Open questions: Chromosome condensation - Why does a chromosome look like a chromosome?

Frank Uhlmann BMC Biology 2013, 11:9 (31 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In his contribution to the ‘Open questions’ anniversary collection for BMC Biology, Frank Uhlmann poses the unsolved problem of chromosome packaging

Comment   Open Access

Open questions - in brief: Beyond -omics, missing motor proteins, and getting from molecules to organisms

Stephen J Benkovic, Julie Theriot, Dagmar Ringe BMC Biology 2013, 11:8 (31 January 2013)

Abstract | Full text | PDF | PubMed

Editorial   Open Access

Open questions in biology - a tenth anniversary series

Miranda Robertson BMC Biology 2013, 11:7 (31 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

To celebrate its tenth anniversary, BMC Biology asked its Editorial Board members to write a paragraph or two on their favorite open questions in biology, and this month it publishes the first contributions, on topics from the challenges of proteomics to the mechanisms of apoptosis.

Commentary   Open Access

Trade-offs in cavefish sensory capacity

Helen Gunter, Axel Meyer BMC Biology 2013, 11:5 (24 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Gunter and Meyer, commenting on recent research on cavefish eye evolution, explain how new interdisciplinary approaches can lead to fresh insight into old evolutionary questions.

Research article   Open Access

Shift happens: trailing edge contraction associated with recent warming trends threatens a distinct genetic lineage in the marine macroalga Fucus vesiculosus

Katy R Nicastro, Gerardo I Zardi, Sara Teixeira, Joao Neiva, Ester A Serrao, Gareth A Pearson BMC Biology 2013, 11:6 (23 January 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

The Atlantic populations of the macroalga Fucus vesiculosus can be divided into distinguishable northern and southern populations, but a recent range shift northwards – with ocean warming a likely culprit – threatens the southern population with extinction, which would result in a significant loss of genetic diversity.

Commentary   Open Access Highly Accessed

Role of aerobic glycolysis in genetically engineered mouse models of cancer

Chi V Dang BMC Biology 2013, 11:3 (23 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Chi Van Dang gives his perspective on research published in the newly launched Cancer and Metabolism suggesting a new target for intervention in the aerobic glycolysis that supports tumor development.

Methodology article   Open Access

Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation

Tyson A Clark, Xingyu Lu, Khai Luong, Qing Dai, Matthew Boitano, Stephen W Turner, Chuan He, Jonas Korlach BMC Biology 2013, 11:4 (22 January 2013)

Abstract | Provisional PDF | PubMed

Commentary   Open Access Highly Accessed

Revisiting the relationship between regenerative ability and aging

Ashley W Seifert, S Voss BMC Biology 2013, 11:2 (21 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The lens can regenerate in neonate axolotl but only for a defined period. Seifert and Voss speculate that developmental understanding of regeneration may provide insight into aging.

Research article   Open Access Highly Accessed

The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ

Daniel N Düring, Alexander Ziegler, Christopher K Thompson, Andreas Ziegler, Cornelius Faber, Johannes Müller, Constance Scharff, Coen PH Elemans BMC Biology 2013, 11:1 (8 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The three-dimensional anatomy of the zebra finch vocal organ is described in unprecedented detail, providing new insights into the biomechanics of song production in a species widely used as an experimental model for vocal learning.


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