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Research article   Open Access

Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans

Lei Shi, Ming Li, Qiang Lin, Xuebin Qi, Bing Su BMC Biology 2013, 11:62 (22 May 2013)

Abstract | Provisional PDF

Research article   Open Access

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

Laura Wrzosek, Sylvie Miquel, Marie-Louise Noordine, Stephan Bouet, Marie Joncquel Chevalier-Curt, Véronique Robert, Catherine Philippe, Chantal Bridonneau, Claire Cherbuy, Catherine Robbe-Masselot, Philippe Langella, Muriel Thomas BMC Biology 2013, 11:61 (21 May 2013)

Abstract | Provisional PDF | PubMed

Interview   Open Access

In pursuit of an HIV vaccine: an interview with Andrew McMichael

Andrew J McMichael BMC Biology 2013, 11:60 (21 May 2013)

Full text | PDF | PubMed |  Editor’s summary

Can the immune system be induced to protect itself against HIV infection? Andrew McMichael gives his perspective in an interview, explaining the challenges faced in making a vaccine  and why he remains optimistic about the potential of eliciting strong T cell responses for controlling the virus.

Opinion   Open Access

Thirty years on: HIV receptor gymnastics and the prevention of infection

Robin A Weiss BMC Biology 2013, 11:57 (21 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Robin Weiss, in an article to mark the 30th anniversary of the discovery of the human immunodeficiency virus (HIV), reviews the complex interactions of the virus with the specialized surface molecules by which it gains entry into cells, and how this has led to drugs that block it.

Question and Answer   Open Access

Q&A: Antibiotic resistance: what more do we know and what more can we do?

Gerard D Wright BMC Biology 2013, 11:51 (17 May 2013)

Full text | PDF | PubMed |  Editor’s summary

Antibiotic resistance is both an ancient phenomenon and a worsening medical problem. Gerard Wright explains why, and what should be done about it.

Research article   Open Access

On the origin of POU5F1

Stephen Frankenberg, Marilyn B Renfree BMC Biology 2013, 11:56 (9 May 2013)

Abstract | Provisional PDF | PubMed

Research article   Open Access

Spatial and temporal in vivo analysis of circulating and sessile immune cells in mosquitoes: hemocyte mitosis following infection

Jonas G King, Julián F Hillyer BMC Biology 2013, 11:55 (30 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Observations on the number, location, phagocytic activity and cell division of hemocytes in the body cavity of mosquitoes sheds new light on the biology of insect immune system cells.

Commentary   Open Access Highly Accessed

Somatic and visceral nervous systems - an ancient duality

Paola Bertucci, Detlev Arendt BMC Biology 2013, 11:54 (30 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The idea that vertebrates are composed of a ‘visceral’ and ‘somatic’ self, responding to internal and external stimuli, respectively, was first put forward in the 19th century. Now, molecular fingerprinting indicates a duality between the somatic and visceral nervous systems that appears to predate Bilataria.

Research article   Open Access Highly Accessed

Ancient origin of somatic and visceral neurons

Marc Nomaksteinsky, Stefan Kassabov, Zoubida Chettouh, Henri-Corto Stoeklé, Laure Bonnaud, Gilles Fortin, Eric R Kandel, Jean-François Brunet BMC Biology 2013, 11:53 (30 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The great American palaeontologist and anatomist Alfred Romer speculated that early in animal life, an emerging somatic nervous system, focused on the outside world, struggled to dominate the visceral nervous system that takes care of the internal systems that keep us alive. Jean-François Brunet and colleagues identify the molecular signatures that tell the evolutionary tale of this duality.

Research article   Open Access

Statistical support for the hypothesis of developmental constraint in marsupial skull evolution

C Verity Bennett, Anjali Goswami BMC Biology 2013, 11:52 (26 April 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

High-density linkage mapping in a pine tree reveals a genomic region associated with inbreeding depression and provides clues to the extent and distribution of meiotic recombination

Emilie Chancerel, Jean-Baptiste Lamy, Isabelle Lesur, Céline Noirot, Christophe Klopp, François Ehrenmann, Christophe Boury, Grégoire Le Provost, Philippe Label, Céline Lalanne, Valérie Léger, Franck Salin, Jean-Marc Gion, Christophe Plomion BMC Biology 2013, 11:50 (18 April 2013)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Radial glial cells play a key role in echinoderm neural regeneration

Vladimir S Mashanov, Olga R Zueva, José E García-Arrarás BMC Biology 2013, 11:49 (18 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Repair of a cut radial nerve cord in a sea cucumber is mediated by radial glial cells that dedifferentiate, divide and give rise to new neurons.

Anniversary Update   Open Access

Tropical rain forest evolution: palms as a model group

Thomas LP Couvreur, William J Baker BMC Biology 2013, 11:48 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

White-nose syndrome in bats: illuminating the darkness

Paul M Cryan, Carol Meteyer, Justin G Boyles, David S Blehert BMC Biology 2013, 11:47 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Seeing the Tree of Life behind the phylogenetic forest

Pere Puigbò, Yuri I Wolf, Eugene V Koonin BMC Biology 2013, 11:46 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Arthropods and inherited bacteria: from counting the symbionts to understanding how symbionts count

Olivier Duron, Gregory DD Hurst BMC Biology 2013, 11:45 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Segment assembly, structure alignment and iterative simulation in protein structure prediction

Yang Zhang, Jeffrey Skolnick BMC Biology 2013, 11:44 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Systematic curation of protein and genetic interaction data for computable biology

Kara Dolinski, Andrew Chatr-aryamontri, Mike Tyers BMC Biology 2013, 11:43 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Neurosensory transmission without a synapse: new perspectives on taste signaling

Sue C Kinnamon BMC Biology 2013, 11:42 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Fuzzy species revisited

William P Hanage BMC Biology 2013, 11:41 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

The new micro-kingdoms of eukaryotes

Jan Pawlowski BMC Biology 2013, 11:40 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Editorial   Open Access

Tenth anniversary updates from our authors

Penelope Austin, Kester Jarvis BMC Biology 2013, 11:39 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Opinion   Open Access

Of flies and men: insights on organismal metabolism from fruit flies

Akhila Rajan, Norbert Perrimon BMC Biology 2013, 11:38 (15 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

For many reasons metabolism is now a high-profile topic, and in an update to mark the tenth anniversary of BMC Biology, Norbert Perrimon and Akhila Rajan review the remarkable similarities that make Drosophila a model for mammalian metabolism, and some recent advances made possible by the advantages of this model organism.

Review   Open Access

Drugging Hedgehog: signaling the pathway to translation

Tom J Carney, Philip W Ingham BMC Biology 2013, 11:37 (15 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Ten years ago Jeff Porter and colleagues published a screen for small-molecule modulators of the Hedgehog signaling pathway in the Journal of Biology. For BMC Biology’s 10th anniversary, Tom Carney and Philip Ingham discuss the far-reaching clinical impact of some of the agonists and antagonists they discovered.

Comment   Open Access Highly Accessed

Domesticating the beast

Virginia Walbot BMC Biology 2013, 11:35 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In 2009, Virginia Walbot commented ‘Are we training pit bulls to review our manuscripts?’ Revisiting the topic, she asks if we can tame our pit bull reviewers by involving students more in peer review and teaching them to see things from an authors’ perspective and the perspective of the journal that is responsible for making a decision on publication.

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