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		Question and Answer Q&A: Evolutionary capacitance Joanna Masel BMC Biology 2013, 11:103 (30 September 2013) Full text \| PDF \| Editor’s summary Joanna Masel explains how evolvability may be conferred by molecular "switches" that can expose cryptic mutations and allow selection to act on them, with the potential for adaptive changes in phenotype.
		Commentary Deciphering the role of natural variation in age-related protein homeostasis Matt Kaeberlein BMC Biology 2013, 11:102 (30 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Commenting on a study showing that genetic variation in wild strains of C. elegans modifies polyglutamine disease, Matt Kaeberlein explains why this nematode worm has proved a useful model for studying age-associated failures of protein homeostasis, and why the new research holds therapeutic promise.
		Research article Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease Tali Gidalevitz, Ning Wang, Tanuja Deravaj, Jasmine Alexander-Floyd, Richard I Morimoto BMC Biology 2013, 11:100 (30 September 2013) Abstract \| Provisional PDF \| Editor’s summary Genetic background affects the age of onset and severity of human disease caused by protein-destabilizing mutations. Now variation has been found between wild strains of C. elegans in the toxicity of polyglutamine expansion, suggesting multiple paths to the expression of toxicity, and multiple natural genetic modifiers of potential therapeutic relevance.
		Research article Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation Qiuhong Qin, Xiaoxi Wang, Bing Zhou BMC Biology 2013, 11:101 (24 September 2013) Abstract \| Provisional PDF \| PubMed
		Research article The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota Widad Dantoft, Monica M Davis, Jessica M Lindvall, Xiongzhuo Tang, Hanna Uvell, Anna Junell, Anne Beskow, Ylva Engström BMC Biology 2013, 11:99 (6 September 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Diversity is maintained by seasonal variation in species abundance Hideyasu Shimadzu, Maria Dornelas, Peter A Henderson, Anne E Magurran BMC Biology 2013, 11:98 (4 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A fish population dataset collected over 30 years shows a connection between seasonal resource abundance and the maintenance of species diversity.
		Review Modeling the within-host dynamics of HIV infection Alan S Perelson, Ruy M Ribeiro BMC Biology 2013, 11:96 (3 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alan Perelson and Ruy Ribeiro explain how differential equations that model the dynamics of HIV replication in its human host have led to important quantitative insights into the biology of HIV infection.
		Comment Open questions: Zombie projects, translational research, and the real secret of the inside of the cell Gregory A Petsko BMC Biology 2013, 11:97 (2 September 2013) Abstract \| Full text \| PDF \| 1 comment \| Editor’s summary Gregory Petsko, writing for the BMC Biology tenth birthday Open questions series, argues, with his usual forthrightness, that we need to pay more attention to where the balance of ‘big’ and ‘little’ science is going, and remember how little we know about the interior of the cell.
		Comment Low-dose radiation, scientific scrutiny, and requirements for demonstrating effects Anders Møller, Timothy Mousseau BMC Biology 2013, 11:92 (30 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Anders Møller and Timothy Mousseau make a case for more research on chronic radiation exposure, and lay out what they see as the key questions to be answered.
		Interview From aging worms to the influence of the microbiota: an interview with David Weinkove David Weinkove BMC Biology 2013, 11:94 (29 August 2013) Full text \| PDF \| PubMed \| Editor’s summary David Weinkove explains, in an interview on his BMC Award-winning paper, how an unlooked-for effect of the common food supplement folate on aging in C. elegans caused him to refocus his research on the E. coli that they feed on.
		Editorial Tony Pawson and the germination and flowering of cell signaling: an appreciation Bruce J Mayer BMC Biology 2013, 11:95 (28 August 2013) Full text \| PDF \| Editor’s summary The death of Tony Pawson on August 7 was a loss to science and a personal loss to many in his field. Bruce Mayer, in an appreciation of his phenomenal contribution to the understanding of cell signalling, explains how his science grew from the study of an obscure oncogenic kinase, and why he will be so badly missed.
		Research article Gene-environment and protein-degradation signatures characterize genomic and phenotypic diversity in wild Caenorhabditis elegans populations Rita JM Volkers, L Snoek, Caspara J van Hellenberg Hubar, Renata Coopman, Wei Chen, Wentao Yang, Mark G Sterken, Hinrich Schulenburg, Bart P Braeckman, Jan E Kammenga BMC Biology 2013, 11:93 (19 August 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence Irena Manov, Mark Hirsh, Theodore C Iancu, Assaf Malik, Nick Sotnichenko, Mark Band, Aaron Avivi, Imad Shams BMC Biology 2013, 11:91 (9 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Blind mole rats resist cancer induced by chemical carcinogens and their fibroblasts suppress the viability and growth of cancer cell lines.
		Research article Transcription of a protein-coding gene on B chromosomes of the Siberian roe deer (Capreolus pygargus) Vladimir A Trifonov, Polina V Dementyeva, Denis M Larkin, Patricia CM O’Brien, Polina L Perelman, Fengtang Yang, Malcolm A Ferguson-Smith, Alexander S Graphodatsky BMC Biology 2013, 11:90 (6 August 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages Petra Mlcochova, Annegret Pelchen-Matthews, Mark Marsh BMC Biology 2013, 11:89 (2 August 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Pioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain Inmaculada García-Ruiz, Pablo Solís-Muñoz, Daniel Fernández-Moreira, Teresa Muñoz-Yagüe, José A Solís-Herruzo BMC Biology 2013, 11:88 (1 August 2013) Abstract \| Full text \| PDF \| PubMed
		Comment Open questions: two challenges in chemical biology - chemical engineering and the science of diet Philip A Cole BMC Biology 2013, 11:87 (30 July 2013) Full text \| PDF \| PubMed \| Editor’s summary In his contribution to the 10th anniversary Open questions series in BMC Biology, Philip Cole proposes synthetic biology for probing the mysteries of protein modifications and dynamics, and chemoprevention through diet for improving public health.
		Research article Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors Guanghua Yang, Karim Si-Tayeb, Sébastien Corbineau, Rémi Vernet, Régis Gayon, Noushin Dianat, Clémence Martinet, Denis Clay, Sylvie Goulinet-Mainot, Gérard Tachdjian, Gérard Tachdjian, Deborah Burks, Ludovic Vallier, Pascale Bouillé, Anne Dubart-Kupperschmitt, Anne Weber BMC Biology 2013, 11:86 (19 July 2013) Abstract \| Full text \| PDF \| PubMed
		Commentary Viral phylogeny in court: the unusual case of the Valencian anesthetist Anne-Mieke Vandamme, Oliver G Pybus BMC Biology 2013, 11:83 (19 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on the publication of analyses of Heptatis C virus evolution used in a high profile court case, Anne-Mieke Vandamme and Oliver Pybus discuss the increasing use of viral phylogenies in criminal trials and the theoretical and practical challenges associated with this.
		Research article Molecular evolution in court: analysis of a large hepatitis C virus outbreak from an evolving source Fernando González-Candelas, María Bracho, Borys Wróbel, Andrés Moya BMC Biology 2013, 11:76 (19 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Phylogenetic analyses of an exceptionally large and complex outbreak of Hepatitis C virus, previously presented in a trial leading to the conviction of an anesthetist for infecting 275 of his patients, are now published in BMC Biology.
		Research article Juvenile hormone regulation of Drosophila aging Rochele Yamamoto, Hua Bai, Adam G Dolezal, Gro Amdam, Marc Tatar BMC Biology 2013, 11:85 (17 July 2013) Abstract \| Full text \| PDF \| PubMed
		Commentary Brain H2A.Z: the long and the short Juan Ausió BMC Biology 2013, 11:84 (17 July 2013) Abstract \| Full text \| PDF \| PubMed \| 1 comment
		Opinion The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated? Matthew D Hall, Dieter Ebert BMC Biology 2013, 11:79 (15 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Theory suggests that interactions between genes may be more important for determining disease susceptibility than for other complex traits. Matthew Hall and Dieter Ebert look at the evidence, and wonder if the effect of gene interaction may have been overestimated.
		Correspondence Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish: response to Borowsky (2013) Masato Yoshizawa, Kelly E O’Quin, William R Jeffery BMC Biology 2013, 11:82 (11 July 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Correspondence Eye regression in blind Astyanax cavefish may facilitate the evolution of an adaptive behavior and its sensory receptors Richard Borowsky BMC Biology 2013, 11:81 (11 July 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central

	All
		Question and Answer Q&A: Evolutionary capacitance Joanna Masel BMC Biology 2013, 11:103 (30 September 2013) Full text \| PDF \| Editor’s summary Joanna Masel explains how evolvability may be conferred by molecular "switches" that can expose cryptic mutations and allow selection to act on them, with the potential for adaptive changes in phenotype.
		Commentary Deciphering the role of natural variation in age-related protein homeostasis Matt Kaeberlein BMC Biology 2013, 11:102 (30 September 2013) Abstract \| Full text \| PDF \| Editor’s summary Commenting on a study showing that genetic variation in wild strains of C. elegans modifies polyglutamine disease, Matt Kaeberlein explains why this nematode worm has proved a useful model for studying age-associated failures of protein homeostasis, and why the new research holds therapeutic promise.
		Research article Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease Tali Gidalevitz, Ning Wang, Tanuja Deravaj, Jasmine Alexander-Floyd, Richard I Morimoto BMC Biology 2013, 11:100 (30 September 2013) Abstract \| Provisional PDF \| Editor’s summary Genetic background affects the age of onset and severity of human disease caused by protein-destabilizing mutations. Now variation has been found between wild strains of C. elegans in the toxicity of polyglutamine expansion, suggesting multiple paths to the expression of toxicity, and multiple natural genetic modifiers of potential therapeutic relevance.
		Research article Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation Qiuhong Qin, Xiaoxi Wang, Bing Zhou BMC Biology 2013, 11:101 (24 September 2013) Abstract \| Provisional PDF \| PubMed
		Research article The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota Widad Dantoft, Monica M Davis, Jessica M Lindvall, Xiongzhuo Tang, Hanna Uvell, Anna Junell, Anne Beskow, Ylva Engström BMC Biology 2013, 11:99 (6 September 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Diversity is maintained by seasonal variation in species abundance Hideyasu Shimadzu, Maria Dornelas, Peter A Henderson, Anne E Magurran BMC Biology 2013, 11:98 (4 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A fish population dataset collected over 30 years shows a connection between seasonal resource abundance and the maintenance of species diversity.
		Review Modeling the within-host dynamics of HIV infection Alan S Perelson, Ruy M Ribeiro BMC Biology 2013, 11:96 (3 September 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alan Perelson and Ruy Ribeiro explain how differential equations that model the dynamics of HIV replication in its human host have led to important quantitative insights into the biology of HIV infection.
		Comment Open questions: Zombie projects, translational research, and the real secret of the inside of the cell Gregory A Petsko BMC Biology 2013, 11:97 (2 September 2013) Abstract \| Full text \| PDF \| 1 comment \| Editor’s summary Gregory Petsko, writing for the BMC Biology tenth birthday Open questions series, argues, with his usual forthrightness, that we need to pay more attention to where the balance of ‘big’ and ‘little’ science is going, and remember how little we know about the interior of the cell.
		Comment Low-dose radiation, scientific scrutiny, and requirements for demonstrating effects Anders Møller, Timothy Mousseau BMC Biology 2013, 11:92 (30 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Anders Møller and Timothy Mousseau make a case for more research on chronic radiation exposure, and lay out what they see as the key questions to be answered.
		Interview From aging worms to the influence of the microbiota: an interview with David Weinkove David Weinkove BMC Biology 2013, 11:94 (29 August 2013) Full text \| PDF \| PubMed \| Editor’s summary David Weinkove explains, in an interview on his BMC Award-winning paper, how an unlooked-for effect of the common food supplement folate on aging in C. elegans caused him to refocus his research on the E. coli that they feed on.
		Editorial Tony Pawson and the germination and flowering of cell signaling: an appreciation Bruce J Mayer BMC Biology 2013, 11:95 (28 August 2013) Full text \| PDF \| Editor’s summary The death of Tony Pawson on August 7 was a loss to science and a personal loss to many in his field. Bruce Mayer, in an appreciation of his phenomenal contribution to the understanding of cell signalling, explains how his science grew from the study of an obscure oncogenic kinase, and why he will be so badly missed.
		Research article Gene-environment and protein-degradation signatures characterize genomic and phenotypic diversity in wild Caenorhabditis elegans populations Rita JM Volkers, L Snoek, Caspara J van Hellenberg Hubar, Renata Coopman, Wei Chen, Wentao Yang, Mark G Sterken, Hinrich Schulenburg, Bart P Braeckman, Jan E Kammenga BMC Biology 2013, 11:93 (19 August 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence Irena Manov, Mark Hirsh, Theodore C Iancu, Assaf Malik, Nick Sotnichenko, Mark Band, Aaron Avivi, Imad Shams BMC Biology 2013, 11:91 (9 August 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Blind mole rats resist cancer induced by chemical carcinogens and their fibroblasts suppress the viability and growth of cancer cell lines.
		Research article Transcription of a protein-coding gene on B chromosomes of the Siberian roe deer (Capreolus pygargus) Vladimir A Trifonov, Polina V Dementyeva, Denis M Larkin, Patricia CM O’Brien, Polina L Perelman, Fengtang Yang, Malcolm A Ferguson-Smith, Alexander S Graphodatsky BMC Biology 2013, 11:90 (6 August 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages Petra Mlcochova, Annegret Pelchen-Matthews, Mark Marsh BMC Biology 2013, 11:89 (2 August 2013) Abstract \| Full text \| PDF \| PubMed
		Research article Pioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain Inmaculada García-Ruiz, Pablo Solís-Muñoz, Daniel Fernández-Moreira, Teresa Muñoz-Yagüe, José A Solís-Herruzo BMC Biology 2013, 11:88 (1 August 2013) Abstract \| Full text \| PDF \| PubMed
		Comment Open questions: two challenges in chemical biology - chemical engineering and the science of diet Philip A Cole BMC Biology 2013, 11:87 (30 July 2013) Full text \| PDF \| PubMed \| Editor’s summary In his contribution to the 10th anniversary Open questions series in BMC Biology, Philip Cole proposes synthetic biology for probing the mysteries of protein modifications and dynamics, and chemoprevention through diet for improving public health.
		Research article Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors Guanghua Yang, Karim Si-Tayeb, Sébastien Corbineau, Rémi Vernet, Régis Gayon, Noushin Dianat, Clémence Martinet, Denis Clay, Sylvie Goulinet-Mainot, Gérard Tachdjian, Gérard Tachdjian, Deborah Burks, Ludovic Vallier, Pascale Bouillé, Anne Dubart-Kupperschmitt, Anne Weber BMC Biology 2013, 11:86 (19 July 2013) Abstract \| Full text \| PDF \| PubMed
		Commentary Viral phylogeny in court: the unusual case of the Valencian anesthetist Anne-Mieke Vandamme, Oliver G Pybus BMC Biology 2013, 11:83 (19 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on the publication of analyses of Heptatis C virus evolution used in a high profile court case, Anne-Mieke Vandamme and Oliver Pybus discuss the increasing use of viral phylogenies in criminal trials and the theoretical and practical challenges associated with this.
		Research article Molecular evolution in court: analysis of a large hepatitis C virus outbreak from an evolving source Fernando González-Candelas, María Bracho, Borys Wróbel, Andrés Moya BMC Biology 2013, 11:76 (19 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Phylogenetic analyses of an exceptionally large and complex outbreak of Hepatitis C virus, previously presented in a trial leading to the conviction of an anesthetist for infecting 275 of his patients, are now published in BMC Biology.
		Research article Juvenile hormone regulation of Drosophila aging Rochele Yamamoto, Hua Bai, Adam G Dolezal, Gro Amdam, Marc Tatar BMC Biology 2013, 11:85 (17 July 2013) Abstract \| Full text \| PDF \| PubMed
		Commentary Brain H2A.Z: the long and the short Juan Ausió BMC Biology 2013, 11:84 (17 July 2013) Abstract \| Full text \| PDF \| PubMed \| 1 comment
		Opinion The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated? Matthew D Hall, Dieter Ebert BMC Biology 2013, 11:79 (15 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Theory suggests that interactions between genes may be more important for determining disease susceptibility than for other complex traits. Matthew Hall and Dieter Ebert look at the evidence, and wonder if the effect of gene interaction may have been overestimated.
		Correspondence Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish: response to Borowsky (2013) Masato Yoshizawa, Kelly E O’Quin, William R Jeffery BMC Biology 2013, 11:82 (11 July 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Correspondence Eye regression in blind Astyanax cavefish may facilitate the evolution of an adaptive behavior and its sensory receptors Richard Borowsky BMC Biology 2013, 11:81 (11 July 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central