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Research article   Open Access

Molecular basis for prey relocation in viperid snakes

Anthony J Saviola, David Chiszar, Chardelle Busch, Stephen P Mackessy BMC Biology 2013, 11:20 (1 March 2013)

Abstract | Provisional PDF |  Editor’s summary

Viperid snakes bite their prey and then let them go to avoid retaliation. By measuring snake behavior and analysing venom chemistry, Stephen Mackessy and colleagues provide an answer to how they find them again.

Research article   Open Access

A functional genomics screen for microRNA regulators of NF-kappaB signaling

Anthony O Olarerin-George, Lauren Anton, Yih-Chii Hwang, Michal A Elovitz, John B Hogenesch BMC Biology 2013, 11:19 (28 February 2013)

Abstract | Provisional PDF

Editorial   Open Access

Q&A: Re-review opt-out and painless publishing

Miranda Robertson BMC Biology 2013, 11:18 (28 February 2013)

Abstract | Full text | PDF |  Editor’s summary

BMC Biology operates on the principle that the function of a journal is to facilitate publication of sound research results. Miranda Robertson reviews in Q&A format the journal’s re-review opt-out policy and how it has worked over the four years of its operation.

Comment   Open Access

Open questions: What is there left for cell biologists to do?

Sean Munro BMC Biology 2013, 11:16 (27 February 2013)

Abstract | Full text | PDF |  Editor’s summary

In a contribution to the 10th anniversary series on open questions in biology, Sean Munro asks provocatively what there is left for cell biologists to do, and with great elan and a touch of waspish humor produces five unanswered questions on issues from the special properties of non-dividing cells to the architecture of the brain.

Research article   Open Access

Genome mining for methanobactins

Grace E Kenney, Amy C Rosenzweig BMC Biology 2013, 11:17 (26 February 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Methanotrophic bacteria have potential as a biological methane sink, and methanobactins are a set of peptides important in regulating this activity. A genome mining study highlights genes involved in methanobactin production, but also suggests that not all methanotrophs have them.

Research article   Open Access

Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts

Jose Vinuelas, Gael Kaneko, Antoine Coulon, Elodie Vallin, Valerie Morin, Camila Mejia-Pous, Jean-Jacques Kupiec, Guillaume Beslon, Olivier Gandrillon BMC Biology 2013, 11:15 (25 February 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A combined biological and computational approach adds further detail to a growing body of evidence that most genes undergo short bursts of transcription interspersed between long periods of downtime.

Commentary   Open Access

Predicting the evolution of antibiotic resistance

Martijn F Schenk, J Arjan GM de Visser BMC Biology 2013, 11:14 (22 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Commenting on research in BMC Evolutionary Biology, Arjan de Visser and Martijn Schenk discuss how two genetic properties, pleiotropy and epistasis, might help us to predict the evolution of antibiotic resistance.

Research article   Open Access

Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles

Jingxia Xu, Thomas Gridley BMC Biology 2013, 11:13 (13 February 2013)

Abstract | Provisional PDF | PubMed

Research article   Open Access

MST1, a key player, in enhancing fast skeletal muscle atrophy

Bin Wei, Wen Dui, Dong Liu, Yan Xing, Zengqqiang Yuan, Guangju Ji BMC Biology 2013, 11:12 (1 February 2013)

Abstract | Provisional PDF | PubMed

Comment   Open Access

Open questions: Chromosome condensation - Why does a chromosome look like a chromosome?

Frank Uhlmann BMC Biology 2013, 11:9 (31 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In his contribution to the ‘Open questions’ anniversary collection for BMC Biology, Frank Uhlmann poses the unsolved problem of chromosome packaging

Comment   Open Access

Open questions - in brief: Beyond -omics, missing motor proteins, and getting from molecules to organisms

Stephen J Benkovic, Julie Theriot, Dagmar Ringe BMC Biology 2013, 11:8 (31 January 2013)

Abstract | Full text | PDF | PubMed

Editorial   Open Access

Open questions in biology - a tenth anniversary series

Miranda Robertson BMC Biology 2013, 11:7 (31 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

To celebrate its tenth anniversary, BMC Biology asked its Editorial Board members to write a paragraph or two on their favorite open questions in biology, and this month it publishes the first contributions, on topics from the challenges of proteomics to the mechanisms of apoptosis.

Methodology article   Open Access

Multi-channel acoustic recording and automated analysis of Drosophila courtship songs

Benjamin J Arthur, Tomoko Sunayama-Morita, Philip Coen, Mala Murthy, David L. Stern BMC Biology 2013, 11:11 (31 January 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Drosophila fruit flies' "singing" during courtship is a model system for both genetic and neural control of behaviour. A newly-designed recording system allows for analysis of the songs' various rhythms and cycles in unprecedented detail.

Comment   Open Access

Open questions: missing pieces from the immunological jigsaw puzzle

Gillian M Griffiths BMC Biology 2013, 11:10 (31 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Gillian Griffiths, in her ‘Open questions’ contribution for BMC Biology, pinpoints some critical missing links in the cell-biological specializations of immune cells

Commentary   Open Access

Trade-offs in cavefish sensory capacity

Helen Gunter, Axel Meyer BMC Biology 2013, 11:5 (24 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Gunter and Meyer, commenting on recent research on cavefish eye evolution, explain how new interdisciplinary approaches can lead to fresh insight into old evolutionary questions.

Research article   Open Access

Shift happens: trailing edge contraction associated with recent warming trends threatens a distinct genetic lineage in the marine macroalga Fucus vesiculosus

Katy R Nicastro, Gerardo I Zardi, Sara Teixeira, Joao Neiva, Ester A Serrao, Gareth A Pearson BMC Biology 2013, 11:6 (23 January 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

The Atlantic populations of the macroalga Fucus vesiculosus can be divided into distinguishable northern and southern populations, but a recent range shift northwards – with ocean warming a likely culprit – threatens the southern population with extinction, which would result in a significant loss of genetic diversity.

Commentary   Open Access Highly Accessed

Role of aerobic glycolysis in genetically engineered mouse models of cancer

Chi V Dang BMC Biology 2013, 11:3 (23 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Chi Van Dang gives his perspective on research published in the newly launched Cancer and Metabolism suggesting a new target for intervention in the aerobic glycolysis that supports tumor development.

Methodology article   Open Access

Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation

Tyson A Clark, Xingyu Lu, Khai Luong, Qing Dai, Matthew Boitano, Stephen W Turner, Chuan He, Jonas Korlach BMC Biology 2013, 11:4 (22 January 2013)

Abstract | Provisional PDF | PubMed

Commentary   Open Access Highly Accessed

Revisiting the relationship between regenerative ability and aging

Ashley W Seifert, S Voss BMC Biology 2013, 11:2 (21 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The lens can regenerate in neonate axolotl but only for a defined period. Seifert and Voss speculate that developmental understanding of regeneration may provide insight into aging.

Research article   Open Access Highly Accessed

The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ

Daniel N Düring, Alexander Ziegler, Christopher K Thompson, Andreas Ziegler, Cornelius Faber, Johannes Müller, Constance Scharff, Coen PH Elemans BMC Biology 2013, 11:1 (8 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The three-dimensional anatomy of the zebra finch vocal organ is described in unprecedented detail, providing new insights into the biomechanics of song production in a species widely used as an experimental model for vocal learning.

Research article   Open Access Highly Accessed

Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish

Masato Yoshizawa, Yoshiyuki Yamamoto, Kelly E O'Quin, William R Jeffery BMC Biology 2012, 10:108 (27 December 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The evolutionary loss of eyes is a process repeated in different cavefish populations, and both neutral and adaptive explanations have been put forward. A study of genetic linkage in an Astyanax population suggests that an antagonostic relationship between eye development and sensors for detecting vibration - an important behaviour in the dark cave environment - is responsible.

 

Research article   Open Access Highly Accessed

Genomic organization, evolution, and expression of photoprotein and opsin genes in Mnemiopsis leidyi: a new view of ctenophore photocytes

Christine E Schnitzler, Kevin Pang, Meghan L Powers, Adam M Reitzel, Joseph F Ryan, David Simmons, Takashi Tada, Morgan Park, Jyoti Gupta, Shelise Y Brooks, Robert W Blakesley, Shozo Yokoyama, Steven HD Haddock, Mark Q Martindale, Andreas D Baxevanis BMC Biology 2012, 10:107 (21 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The comb jelly Mnemiopsis leidyi has at least ten distinct genes encoding enzymes that catalyse bioluminescence. Their evolutionary origin traces back to the earliest animals, and in Mnemiopsis they are co-expressed with light-absorbing opsin in light-detecting cells. 

Question and Answer   Open Access Highly Accessed

Q&A: Extinctions and the impact of Homo sapiens

Robert M May BMC Biology 2012, 10:106 (20 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Robert May explores in Q&A format the reasons for the acceleration of extinctions due to the activities of a single species (ours), and asks why it matters.

Commentary   Open Access

No strings attached: new insights into epithelial morphogenesis

Lance A Davidson BMC Biology 2012, 10:105 (20 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

What regulates epithelial cell bending during early development? Lance Davidson comments on a paper from Zhirong Bao and colleagues where cell ingression in worm gastrulation is driven by dynamic cytoskeletal changes and cortical flow, challenging previous “purse-string” constriction models.

Opinion   Open Access Highly Accessed

Cilia, calcium and the basis of left-right asymmetry

Dominic P Norris BMC Biology 2012, 10:102 (19 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

What determines left-right asymmetry in the early embryo? Dominic Norris reviews recent insights into mechanisms, including the role of cilia, a leftward flow of liquid in the embryo and asymmetric activation gene activation.

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