BMC Biology is the flagship biology journal of the BMC series, publishing peer-reviewed research and methodology articles of special importance and broad interest in any area of biology, as well as commissioned reviews, opinion pieces, comment and Q&As on topics of special or topical interest.
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Review & comment
Mark Pellegrino and Cole Haynes, in a topical review, explain how mitochondrial stress leads to failures of mitochondrial protein import that are exploited to trigger the repair or the segregation and destruction of damaged mitochondria in infection and disease
How is organ size regulated? Khammash and colleagues address this central mystery of biology with a mathematical model, and in an accompanying Commentary Charles Stevens explains why this is not ‘just a theory’.
No-one who knows anything about life would accuse it of being characterised by equilibrium - yet this is exactly the assumption many biological models make. Highlighting a recent paper from Jeremy Gunawardena and colleagues, David Pincus discusses why it's important to incorporate non-equilibrium states into models of gene regulation, and how theoreticians are grappling with the problems inherent in doing so.
In her open questions contribution to BMC Biology, Heidi McBride urges the importance of integrating the emerging cell and molecular biology, with all its –omics, into a new physiological understanding of the mitochondrion
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Question and answer
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Journal of Biology
BMC Biology assimilated the philosophy and distinguished Editorial Board and history of its sister journal Journal of Biology on fusion of the two journals in 2010. The full archive of Journal of Biology is available from its own archive website, and the objectives and aspirations of the combined journal are explained in the editorial that accompanied the fusion.