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	26. 902 Accesses	Software Automics: an integrated platform for NMR-based metabonomics spectral processing and data analysis Tao Wang, Kang Shao, Qinying Chu, Yanfei Ren, Yiming Mu, Lijia Qu, Jie He, Changwen Jin, Bin Xia BMC Bioinformatics 2009, 10:83 (16 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary 'Automics' is a new open-source software package for integrated spectral processing and analysis of nuclear magnetic resonance-based metabonomic datasets, which would otherwise require the use of several separate programs.
	27. 884 Accesses	Software Software for selecting the most informative sets of genomic loci for multi-target microbial typing Matthew VN O’Sullivan, Vitali Sintchenko, Gwendolyn L Gilbert BMC Bioinformatics 2013, 14:148 (1 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	28. 877 Accesses	Software MIMO: an efficient tool for molecular interaction maps overlap Pietro Di Lena, Gang Wu, Pier Luigi Martelli, Rita Casadio, Christine Nardini BMC Bioinformatics 2013, 14:159 (15 May 2013) Abstract \| Provisional PDF \| PubMed
	29. 853 Accesses	Software Cloud BioLinux: pre-configured and on-demand bioinformatics computing for the genomics community Konstantinos Krampis, Tim Booth, Brad Chapman, Bela Tiwari, Mesude Bicak, Dawn Field, Karen E Nelson BMC Bioinformatics 2012, 13:42 (19 March 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cloud BioLinux includes over 135 pre-configured bioinformatics tools for sequence alignment, clustering, assembly, display and phylogeny, aimed at reducing costs to researchers of maintaining and configuring hardware, and encouraging sharing of codebase.
	30. 853 Accesses	Software Mojo Hand, a TALEN design tool for genome editing applications Kevin L Neff, David P Argue, Alvin C Ma, Han B Lee, Karl J Clark, Stephen C Ekker BMC Bioinformatics 2013, 14:1 (16 January 2013) Abstract \| Full text \| PDF \| PubMed
	31. 839 Accesses	Methodology article Ensemble-based prediction of RNA secondary structures Nima Aghaeepour, Holger H Hoos BMC Bioinformatics 2013, 14:139 (24 April 2013) Abstract \| Provisional PDF \| PubMed
	32. 838 Accesses	Software Quality control, analysis and secure sharing of Luminex(R) immunoassay data using the open source LabKey Server platform Josh Eckels, Cory Nathe, Elizabeth K Nelson, Sara G Shoemaker, Elizabeth Nostrand, Nicole L Yates, Vicki C Ashley, Linda J Harris, Mark Bollenbeck, Youyi Fong, Georgia D Tomaras, Britt Piehler BMC Bioinformatics 2013, 14:145 (30 April 2013) Abstract \| Provisional PDF \| PubMed
	33. 826 Accesses	Research article Compression-based distance (CBD): a simple, rapid, and accurate method for microbiota composition comparison Fang Yang, Nicholas Chia, Bryan A White, Lawrence B Schook BMC Bioinformatics 2013, 14:136 (23 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	34. 805 Accesses	Software pROC: an open-source package for R and S+ to analyze and compare ROC curves Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frédérique Lisacek, Jean-Charles Sanchez, Markus Müller BMC Bioinformatics 2011, 12:77 (17 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	35. 800 Accesses	Research article An algorithm for automated closure during assembly Sergey Koren, Jason R Miller, Brian P Walenz, Granger Sutton BMC Bioinformatics 2010, 11:457 (10 September 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	36. 788 Accesses	Research article Combining MEDLINE and publisher data to create parallel corpora for the automatic translation of biomedical text Antonio Jimeno Yepes, Élise Prieur-Gaston, Aurélie Névéol BMC Bioinformatics 2013, 14:146 (30 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	37. 771 Accesses	Software Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool Edward Y Chen, Christopher M Tan, Yan Kou, Qiaonan Duan, Zichen Wang, Gabriela Meirelles, Neil R Clark, Avi Ma’ayan BMC Bioinformatics 2013, 14:128 (15 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	38. 755 Accesses	Research article A flood-based information flow analysis and network minimization method for gene regulatory networks Andreas Pavlogiannis, Vadim Mozhayskiy, Ilias Tagkopoulos BMC Bioinformatics 2013, 14:137 (24 April 2013) Abstract \| Provisional PDF \| PubMed
	39. 755 Accesses	Software The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes F Meyer, D Paarmann, M D'Souza, R Olson, EM Glass, M Kubal, T Paczian, A Rodriguez, R Stevens, A Wilke, J Wilkening, RA Edwards BMC Bioinformatics 2008, 9:386 (19 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	40. 752 Accesses	Research article Conotoxin protein classification using free scores of words and support vector machines Nazar Zaki, Stefan Wolfsheimer, Gregory Nuel, Sawsan Khuri BMC Bioinformatics 2011, 12:217 (29 May 2011) Abstract \| Full text \| PDF \| PubMed
	41. 744 Accesses	Methodology article Statistical significance of quantitative PCR Yann Karlen, Alan McNair, Sébastien Perseguers, Christian Mazza, Nicolas Mermod BMC Bioinformatics 2007, 8:131 (20 April 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	42. 743 Accesses	Research article PubMed related articles: a probabilistic topic-based model for content similarity Jimmy Lin, W John Wilbur BMC Bioinformatics 2007, 8:423 (30 October 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	43. 705 Accesses	Proceedings An overview of the Hadoop/MapReduce/HBase framework and its current applications in bioinformatics Ronald C Taylor BMC Bioinformatics 2010, 11(Suppl 12):S1 (21 December 2010) Abstract \| Full text \| PDF \| PubMed
	44. 704 Accesses	Research article Empirical Bayesian analysis of paired high-throughput sequencing data with a beta-binomial distribution Thomas J Hardcastle, Krystyna A Kelly BMC Bioinformatics 2013, 14:135 (23 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	45. 705 Accesses	Research article Quantifying variances in comparative RNA secondary structure prediction James WJ Anderson, Ádám Novák, Zsuzsanna Sükösd, Michael Golden, Preeti Arunapuram, Ingolfur Edvardsson, Jotun Hein BMC Bioinformatics 2013, 14:149 (1 May 2013) Abstract \| Provisional PDF \| PubMed
	46. 680 Accesses	Software MUSCLE: a multiple sequence alignment method with reduced time and space complexity Robert C Edgar BMC Bioinformatics 2004, 5:113 (19 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	47. 667 Accesses	Software A metadata-aware application for remote scoring and exchange of tissue microarray images Lorna Morris, Andrew Tsui, Charles Crichton, Steve Harris, Peter H Maccallum, William J Howat, Jim Davies, James D Brenton, Carlos Caldas BMC Bioinformatics 2013, 14:147 (1 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	48. 660 Accesses	Research article Mining prokaryotic genomes for unknown amino acids: a stop-codon-based approach Masashi Fujita, Hisaaki Mihara, Susumu Goto, Nobuyoshi Esaki, Minoru Kanehisa BMC Bioinformatics 2007, 8:225 (28 June 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary As two rare amino acids are stop codon-encoded, a 23rd undiscovered amino acid might also be, but a systematic search for 'readthrough proteins’ in prokaryotes showed no trace of an additional stop codon-encoded amino acid.
	49. 652 Accesses	Research article Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis Pan Du, Xiao Zhang, Chiang-Ching Huang, Nadereh Jafari, Warren A Kibbe, Lifang Hou, Simon M Lin BMC Bioinformatics 2010, 11:587 (30 November 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	50. 651 Accesses	Methodology article Greedy feature selection for glycan chromatography data with the generalized Dirichlet distribution Marie C Galligan, Radka Saldova, Matthew P Campbell, Pauline M Rudd, Thomas B Murphy BMC Bioinformatics 2013, 14:155 (7 May 2013) Abstract \| Provisional PDF \| PubMed