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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Danielle Burgess PhD
Welcome to BMC Bioinformatics published by BioMed Central
BMC Bioinformatics is an open access journal publishing original peer-reviewed research articles in all aspects of the development, testing and novel application of computational and statistical methods for the modeling and analysis of all kinds of biological data, as well as other areas of computational biology.
BMC Bioinformatics (ISSN 1471-2105) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, EMBASE, Scopus, Thomson Reuters (ISI) and Google Scholar.
BMC Bioinformatics 2010, 11 :68
A new method for clustering time-course microarray gene expression datasets, using a Granger causality approach to test the temporal relationships between genes, provides a promising way to group functionally related genes.
BMC Bioinformatics 2010, 11 :57
Combining sequence and structural information can be used successfully to predict substrate specificity of members of the acyl:CoA synthetase family, while using homology for the same task proves difficult due to great diversity within the family.
BMC Bioinformatics 2009, 10 :447
Next generation sequencing technologies have resulted in an explosion of transcriptome projects in non-model organisms and est2assembly is a useful tool for the assembly, annotation, analysis and visualization of such data.
BMC Bioinformatics 2009, 10 :421
With the advent of more complete genomes BLAST has been re-written to include a new set of command line searches and a new modular structure, giving substantial speed improvements for long queries and an improved user interface.
BMC Bioinformatics 2009, 10 :402
Double filtering using fold change and t test to find differentially expressed genes loses power due to differing assumptions about variance, whereas combining Bayesian mixture models with SAM approaches the performance of the theoretically best likelihood ratio test statistic.
Volume 11 Suppl 1
Research
Bangalore, India. 18-21 January 2010
Volume 10 Suppl 15
Proceedings
Singapore. 7-11 September 2009
Volume 10 Suppl 14
Research
more info ]
Methodology article
Physicochemical property distributions for accurate and rapid pairwise protein homology detection Bobbie-Jo M Webb-Robertson, Kyle G Ratuiste, Christopher S Oehmen BMC Bioinformatics 2010, 11 :145 (19 [Abstract ] [Provisional PDF ]
Research article
Large-scale prediction of protein-protein interactions from structures Martial Hue, Michael Riffle, Jean-Philippe Vert, William S Noble BMC Bioinformatics 2010, 11 :144 (18 [Abstract ] [Provisional PDF ]
Software
MPprimer: a program for reliable multiplex PCR primer design Zhiyong Shen, Wubin Qu, Wen Wang, Yiming Lu, Yonghong Wu, Zhifeng Li, Xingyi Hang, Xiaolei Wang, Dongsheng Zhao, Chenggang Zhang BMC Bioinformatics 2010, 11 :143 (18 [Abstract ] [Provisional PDF ]
Software
MISHIMA - a new method for high speed multiple alignment of nucleotide sequences of bacterial genome scale data Kirill Kryukov, Naruya Saitou BMC Bioinformatics 2010, 11 :142 (18 [Abstract ] [Provisional PDF ]
Software
YODA: Software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast Brady Olsen, Christopher J Murakami, Matt Kaeberlein BMC Bioinformatics 2010, 11 :141 (18 [Abstract ] [Provisional PDF ]
Research article
Gene regulatory networks modelling using a dynamic evolutionary hybrid Ioannis A Maraziotis, Andrei Dragomir, Dimitris Thanos BMC Bioinformatics 2010, 11 :140 (18 [Abstract ] [Provisional PDF ]
Methodology article
Correcting for the effects of natural abundance in stable isotope resolved metabolomics experiments involving ultra-high resolution mass spectrometry Hunter N B Moseley BMC Bioinformatics 2010, 11 :139 (17 [Abstract ] [Provisional PDF ]
Methodology article
An optimized TOPS+ comparison method for enhanced TOPS models Mallika Veeramalai, David Gilbert, Gabriel Valiente BMC Bioinformatics 2010, 11 :138 (17 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Indirect two-sided relative ranking: a robust similarity measure for gene expression data Louis Licamele, Lise Getoor BMC Bioinformatics 2010, 11 :137 (17 [Abstract ] [Provisional PDF ]
Research article
Analysis of DNA strand-specific differential expression with high density tiling microarrays Luis Quintales, Mar Sanchez, Francisco Antequera BMC Bioinformatics 2010, 11 :136 (17 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
Library of molecular associations: curating the complex molecular basis of liver diseases Stefan Buchkremer, Jasmin Hendel, Markus Krupp, Arndt Weinmann, Kai Schlamp, Thorsten Maass, Frank Staib, Peter R Galle, Andreas Teufel BMC Genomics 2010, 11 :189 (20 [Abstract ] [Provisional PDF ]
Research
Distinguishing between hot-spots and melting-pots of genetic diversity using haplotype connectivity Binh Nguyen, Andreas Spillner, Brent C Emerson, Vincent Moulton Algorithms for Molecular Biology 2010, 5 :19 (20 [Abstract ] [Provisional PDF ]
Research article
Single feature polymorphism (SFP)-based selective sweep identification and association mapping of growth-related metabolic traits in Arabidopsis thaliana Liam H Childs, Hanna Witucka-Wall, Torsten Gunther, Ronan Sulpice, Maria v. Korff, Mark Stitt, Dirk Walther, Karl J Schmid, Thomas Altmann BMC Genomics 2010, 11 :188 (20 [Abstract ] [Provisional PDF ]
Discovery notes
OST-HTH: a novel predicted RNA-binding domain Vivek Anantharaman, Dapeng Zhang, L Aravind Biology Direct 2010, 5 :13 (19 [Abstract ] [Provisional PDF ]
Research article
Genotype networks in metabolic reaction spaces Areejit Samal, Joao F. Matias Rodrigues, Jurgen Jost, Olivier C. Martin, Andreas Wagner BMC Systems Biology 2010, 4 :30 (19 [Abstract ] [Provisional PDF ]
Short Report
Analysing time course microarray data using Bioconductor: a case study using yeast2 Affymetrix arrays Colin S Gillespie, Guiyuan Lei, Richard J Boys, Amanda Greenall, Darren J Wilkinson BMC Research Notes 2010, 3 :81 (19 [Abstract ] [Provisional PDF ]
Research article
A novel approach to investigate tissue-specific trinucleotide repeat instability Jong-Min Lee, Jie Zhang, Andrew I. Su, John R. Walker, Tim Wiltshire, Kihwa Kang, Ella Dragileva, Tammy Gillis, Edith T. Lopez, Marie-Josee Boily, Michel Cyr, Isaac Kohane, James F. Gusella, Marcy E. MacDonald, Vanessa C. Wheeler BMC Systems Biology 2010, 4 :29 (19 [Abstract ] [Provisional PDF ]
Research
Genetic heterogeneity of residual variance - estimation of variance components using double hierarchical generalized linear models Lars Ronnegard, Majbritt Felleki, Freddy Fikse, Herman A Muller, Erling Strandberg Genetics Selection Evolution 2010, 42 :8 (19 [Abstract ] [Provisional PDF ]
Research
Coregulation mapping based on individual phenotypic variation in response to virus infection German Nudelman, Yongchao Ge, Jianzhong Hu, Madhu Kumar, Jeremy Seto, Jamie L. Duke, Steven H. Kleinstein, Fernand Hayot, Stuart C. Sealfon, James G. Wetmur Immunome Research 2010, 6 :2 (18 [Abstract ] [Provisional PDF ]
Technical Note
Performance evaluation of commercial miRNA expression array platforms Sachin Sah, Matthew N McCall, Deepa Eveleigh, Michael Wilson, Rafael A Irizarry BMC Research Notes 2010, 3 :80 (18 [Abstract ] [Provisional PDF ]
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