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1.

3500
Accesses

Research article   Open Access Highly Accessed

Arg188 in rice sucrose transporter OsSUT1 is crucial for substrate transport

Ye Sun, John M Ward BMC Biochemistry 2012, 13:26 (21 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Arginine-188 of the plant sucrose uptake transporter OsSUT1 is required for substrate translocation but not interaction, implicating the involvement of an alternative substrate binding site in substrate recognition.

2.

2844
Accesses

Research article   Open Access Highly Accessed

A proteomic view on the developmental transfer of homologous 30 kDa lipoproteins from peripheral fat body to perivisceral fat body via hemolymph in silkworm, Bombyx mori

Britto Pakkianathan, Nitin Singh, Muthukalingan Krishnan, Simone König BMC Biochemistry 2012, 13:5 (28 February 2012)

Abstract | Full text | PDF | PubMed

3.

2568
Accesses

Research article   Open Access Highly Accessed

Lipid-bound apolipoproteins in tyrosyl radical-oxidized HDL stabilize ABCA1 like lipid-free apolipoprotein A-I

Mohammad A Hossain, Sereyrath Ngeth, Teddy Chan, Michael N Oda, Gordon A Francis BMC Biochemistry 2012, 13:1 (16 January 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Lipid-bound apolipoproteins on the surface of spherical high density lipoprotein (HDL) particles can behave like lipid-free apolipoprotein A-I (apoA-I) to increase ATP-binding cassette transporter A1 (ABCA1) protein levels and activity.

4.

2486
Accesses

Methodology article   Open Access Highly Accessed

A simplified method for analysis of polyunsaturated fatty acids

Jing X Kang, Jingdong Wang BMC Biochemistry 2005, 6:5 (24 March 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

5.

2458
Accesses

Research article   Open Access Highly Accessed

Characterization of a β-glucanase produced by Rhizopus microsporus var. microsporus, and its potential for application in the brewing industry

Klecius Celestino, Ricardo B Cunha, Carlos R Felix BMC Biochemistry 2006, 7:23 (5 December 2006)

Abstract | Full text | PDF | PubMed

6.

2456
Accesses

Research article   Open Access Highly Accessed

Thermodynamic analysis of DNA binding by a Bacillus single stranded DNA binding protein

Esther E Biswas-Fiss, Jirayu Kukiratirat, Subhasis B Biswas BMC Biochemistry 2012, 13:10 (14 June 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Transient formation of a DNA-dependent tetrameric structure enables SSB-BA (single stranded DNA binding protein from Bacillus anthracis) to reversibly form high affinity protein-DNA complexes and may enable SSB-BA to efficiently assemble and disassemble protein-DNA complexes during DNA replication

7.

2297
Accesses

Research article   Open Access Highly Accessed

Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro

Jana Pytelková, Martin Lepšík, Miloslav Šanda, Pavel Talacko, Lucie Marešová, Michael Mareš BMC Biochemistry 2012, 13:3 (31 January 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The first protein-level characterization of the group 4 alpha-amylase allergen Aca s 4 from the food storage mite Acarus siro reveals a distinct inhibition pattern and unusual alpha-amylolytic activity that may play an important role in allergenic hypersensitivity

8.

2208
Accesses

Research article   Open Access Highly Accessed

The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-κB activity by blocking ubiquitination mediated proteasomal degradation of IκBα in human hepatoma cells

Milan Surjit, Bhavna Varshney, Sunil K Lal BMC Biochemistry 2012, 13:7 (16 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The open reading frame 2 glycoprotein of the hepatitis E virus (HEV) inhibits nuclear factor kappa B (NF-kB), which is crucial to host survival, by blocking degradation of cellular I kappa B alpha.

9.

2184
Accesses

Review   Open Access Highly Accessed

Role of the ubiquitin proteasome system in Parkinson's disease

Kah-Leong Lim, Jeanne MM Tan BMC Biochemistry 2007, 8(Suppl 1):S13 (22 November 2007)

Abstract | Full text | PDF | PubMed

10.

2059
Accesses

Research article   Open Access Highly Accessed

Characterization of rubber particles and rubber chain elongation in Taraxacum koksaghyz

Thomas Schmidt, Malte Lenders, Andrea Hillebrand, Nicole van Deenen, Oliver Munt, Rudolf Reichelt, Wolfgang Eisenreich, Rainer Fischer, Dirk Prüfer, Christian Gronover BMC Biochemistry 2010, 11:11 (19 February 2010)

Abstract | Full text | PDF | PubMed

11.

2054
Accesses

Research article   Open Access Highly Accessed

Fatty acyl-CoA reductases of birds

Janine Hellenbrand, Eva-Maria Biester, Jens Gruber, Mats Hamberg, Margrit Frentzen BMC Biochemistry 2011, 12:64 (12 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Fatty acyl-CoA reductases (FARs) cloned from the preening glands of barn owls, chickens and geese represent two distinct groups of isozymes that may be involved in wax ester biosynthesis and other pathways such as ether lipid synthesis

12.

2053
Accesses

Research article   Open Access Highly Accessed

Extraction and inhibition of enzymatic activity of botulinum neurotoxins /B1, /B2, /B3, /B4, and /B5 by a panel of monoclonal anti-BoNT/B antibodies

Suzanne R Kalb, Wanda I Santana, Isin N Geren, Consuelo Garcia-Rodriguez, Jianlong Lou, Theresa J Smith, James D Marks, Leonard A Smith, James L Pirkle, John R Barr BMC Biochemistry 2011, 12:58 (15 November 2011)

Abstract | Full text | PDF | PubMed

13.

2017
Accesses

Research article   Open Access Highly Accessed

Alternative splicing produces structural and functional changes in CUGBP2

Hitoshi Suzuki, Makoto Takeuchi, Ayumu Sugiyama, AHM Alam, Luyen Vu, Yoshiharu Sekiyama, Hieu Dam, Shin-ya Ohki, Toshifumi Tsukahara BMC Biochemistry 2012, 13:6 (20 March 2012)

Abstract | Full text | PDF | PubMed

14.

1983
Accesses

Research article   Open Access Highly Accessed

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

Silvia Jordans, Saša Jenko-Kokalj, Nicole M Kühl, Sofia Tedelind, Wolfgang Sendt, Dieter Brömme, Dušan Turk, Klaudia Brix BMC Biochemistry 2009, 10:23 (22 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Cathepsin cysteine proteases are active under conditions simulating extracellular and intracellular compartments with a range of pHs and redox potentials, as shown by cleavage of the natural substrate thyroglobulin in distinct ways in different physiologic environments.

15.

1960
Accesses

Research article   Open Access Highly Accessed

Acetylcholinesterase assay for cerebrospinal fluid using bupivacaine to inhibit butyrylcholinesterase

Wolfram H Kluge, Harald H Kluge, Heike I Bauer, Stefan Pietsch, Jens Anders, Rudolf A Venbrocks BMC Biochemistry 2001, 2:17 (21 December 2001)

Abstract | Full text | PDF | PubMed

16.

1958
Accesses

Review   Open Access Highly Accessed

Patented small molecule inhibitors in the ubiquitin proteasome system

Philippe Guédat, Frédéric Colland BMC Biochemistry 2007, 8(Suppl 1):S14 (22 November 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

1925
Accesses

Research article   Open Access Highly Accessed

Identification of avian wax synthases

Eva-Maria Biester, Janine Hellenbrand, Jens Gruber, Mats Hamberg, Margrit Frentzen BMC Biochemistry 2012, 13:4 (4 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Homology searching of avian databases has identified wax synthase genes expressed in the bird preen gland; analysis of the expressed proteins confirms they are capable of catalysing wax synthesis.

18.

1890
Accesses

Research article   Open Access Highly Accessed

The role of molecular chaperonins in warm ischemia and reperfusion injury in the steatotic liver: A proteomic study

Venkataswarup Tiriveedhi, Kendra D Conzen, Jane Liaw-Conlin, Gundumi Upadhya, James Malone, R Townsend, Robnet Kerns, Jianluo Jia, Krista Csontos, Sabarinathan Ramachandran, Thallachallour Mohanakumar, Christopher D Anderson, William C Chapman BMC Biochemistry 2012, 13:17 (10 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Reduced chaperonin levels in the steatotic rat liver convey an increased susceptibility to ischemia/reperfusion (I/R) injury during transplant surgery, suggesting chaperone family members as potential targets for improving steatotic liver allograft viability.

19.

1880
Accesses

Research article   Open Access Highly Accessed

The roles of aldehyde dehydrogenases (ALDHs) in the PDH bypass of Arabidopsis

Yanling Wei, Ming Lin, David J Oliver, Patrick S Schnable BMC Biochemistry 2009, 10:7 (25 March 2009)

Abstract | Full text | PDF | PubMed

20.

1866
Accesses

Research article   Open Access Highly Accessed

Insulin glycation by methylglyoxal results in native-like aggregation and inhibition of fibril formation

Luis MA Oliveira, Ana Lages, Ricardo A Gomes, Henrique Neves, Carlos Família, Ana V Coelho, Alexandre Quintas BMC Biochemistry 2011, 12:41 (5 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

1865
Accesses

Research article   Open Access Highly Accessed

The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols

Arumugam Rajavelu, Zumrad Tulyasheva, Rakesh Jaiswal, Albert Jeltsch, Nikolai Kuhnert BMC Biochemistry 2011, 12:16 (21 April 2011)

Abstract | Full text | PDF | PubMed

22.

1864
Accesses

Research article   Open Access Highly Accessed

Measurement of peroxisomal enzyme activities in the liver of brown trout (Salmo trutta), using spectrophotometric methods

Maria Rocha, Eduardo Rocha, Albina D Resende, Alexandre Lobo-da-Cunha BMC Biochemistry 2003, 4:2 (11 March 2003)

Abstract | Full text | PDF | PubMed

23.

1838
Accesses

Research article   Open Access Highly Accessed

Purification and characterization of cysteine protease from germinating cotyledons of horse gram

Rajeswari Jinka, Vadde Ramakrishna, Sridhar K Rao, Ramakrishna P Rao BMC Biochemistry 2009, 10:28 (17 November 2009)

Abstract | Full text | PDF | PubMed

24.

1838
Accesses

Research article   Open Access Highly Accessed

Regulation of the BRCA1 gene by an SRC3/53BP1 complex

Dale Corkery, Gobi Thillainadesan, Niamh Coughlan, Ryan D Mohan, Majdina Isovic, Marc Tini, Joseph Torchia BMC Biochemistry 2011, 12:50 (13 September 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The tumor suppressor 53BP1 and the oncogene SRC3 occupy the same region of the BRCA1 promoter and are both required for BRCA1 expression, suggesting that this complex plays an important role in DNA repair and genomic stability

25.

1790
Accesses

Review   Open Access Highly Accessed

HPV E6, E6AP and cervical cancer

Sylvie Beaudenon, Jon M Huibregtse BMC Biochemistry 2008, 9(Suppl 1):S4 (21 October 2008)

Abstract | Full text | PDF | PubMed

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