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	1. 580 Accesses	Research article Side chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the V_H1-69 germline segment Alex Stewart, Joseph S Harrison, Lauren K Regula, Jonathan R Lai BMC Biochemistry 2013, 14:9 (8 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	2. 535 Accesses	Research article The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand Amanda J Boyle, Leigh Ann Roddick, Varsha Bhakta, Melissa D Lambourne, Murray S Junop, Patricia C Liaw, Jeffrey I Weitz, William P Sheffield BMC Biochemistry 2013, 14:6 (7 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An isolated form of N-terminal acidic extension of Heparin cofactor II (HCII 1-75) binds thrombin with a higher affinity than glycosaminoglycans (GAGs), suggesting that this region of Heparin cofactor II (HCII) is required for binding of thrombin exosite 1.
	3. 447 Accesses	Reviewer acknowledgement Annual acknowledgement of manuscript reviewers Emilie Aime BMC Biochemistry 2013, 14:7 (21 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	4. 418 Accesses	Research article Biochemical characterization of three putative ATPases from a new type IV secretion system of Aeromonas veronii plasmid pAC3249A Ashraf Y Rangrez, Mohammad Y Abajy, Walter Keller, Yogesh Shouche, Elisabeth Grohmann BMC Biochemistry 2010, 11:10 (9 February 2010) Abstract \| Full text \| PDF \| PubMed
	5. 409 Accesses	Research article Glutathionylation of beta-actin via a cysteinyl sulfenic acid intermediary Magnus Johansson, Mathias Lundberg BMC Biochemistry 2007, 8:26 (10 December 2007) Abstract \| Full text \| PDF \| PubMed
	6. 379 Accesses	Research article Nedd8 processing enzymes in Schizosaccharomyces pombe Jean E O’Donoghue, Dawadschargal Bech-Otschir, Ida B Larsen, Mairi Wallace, Rasmus Hartmann-Petersen, Colin Gordon BMC Biochemistry 2013, 14:8 (15 March 2013) Abstract \| Full text \| PDF \| PubMed
	7. 362 Accesses	Research article Construction of a chimeric thermoacidophilic beta-endoglucanase Kristina Kufner, Georg Lipps BMC Biochemistry 2013, 14:11 (29 April 2013) Abstract \| Full text \| PDF \| PubMed
	8. 304 Accesses	Research article Expression, purification and biochemical characterization of Schizosaccharomyces pombe Mcm4, 6 and 7 Meng Xu, Y Paul Chang, Xiaojiang S Chen BMC Biochemistry 2013, 14:5 (27 February 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	9. 304 Accesses	Methodology article A simplified method for analysis of polyunsaturated fatty acids Jing X Kang, Jingdong Wang BMC Biochemistry 2005, 6:5 (24 March 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	10. 273 Accesses	Research article Metazoan-like signaling in a unicellular receptor tyrosine kinase Kira P Schultheiss, Barbara P Craddock, Michael Tong, Markus Seeliger, W Todd Miller BMC Biochemistry 2013, 14:4 (12 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary RTKB2 kinase from the unicellular choanoflagellate Monosiga brevicollis demonstrates regulatory functions as complex as those performed by mammalian receptor tyrosine kinases (RTKs), showing that complex signal transduction circuitry predates the evolution of metazoans.
	11. 271 Accesses	Review Role of the ubiquitin proteasome system in Parkinson's disease Kah-Leong Lim, Jeanne MM Tan BMC Biochemistry 2007, 8(Suppl 1):S13 (22 November 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	12. 243 Accesses	Research article Fatty acyl-CoA reductases of birds Janine Hellenbrand, Eva-Maria Biester, Jens Gruber, Mats Hamberg, Margrit Frentzen BMC Biochemistry 2011, 12:64 (12 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Fatty acyl-CoA reductases (FARs) cloned from the preening glands of barn owls, chickens and geese represent two distinct groups of isozymes that may be involved in wax ester biosynthesis and other pathways such as ether lipid synthesis
	13. 243 Accesses	Research article Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins Xinwen Liang, Alaattin Kaya, Yan Zhang, Dung Le, Deame Hua, Vadim N Gladyshev BMC Biochemistry 2012, 13:21 (23 October 2012) Abstract \| Full text \| PDF \| PubMed
	14. 240 Accesses	Research article Characterization of a β-glucanase produced by Rhizopus microsporus var. microsporus, and its potential for application in the brewing industry Klecius Celestino, Ricardo B Cunha, Carlos R Felix BMC Biochemistry 2006, 7:23 (5 December 2006) Abstract \| Full text \| PDF \| PubMed
	15. 240 Accesses	Research article Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life Pernille Bøttger, Lene Pedersen BMC Biochemistry 2011, 12:21 (17 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	16. 232 Accesses	Research article Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells Rita De Gasperi, Miguel A Gama Sosa, Gregory A Elder BMC Biochemistry 2012, 13:28 (21 December 2012) Abstract \| Full text \| PDF \| PubMed
	17. 226 Accesses	Research article Ski-interacting protein (SKIP) interacts with androgen receptor in the nucleus and modulates androgen-dependent transcription Daniel Abankwa, Susan M Millard, Nick Martel, Catherine S Choong, Miao Yang, Lisa M Butler, Grant Buchanan, Wayne D Tilley, Nobuhide Ueki, Michael J Hayman, Gary M Leong BMC Biochemistry 2013, 14:10 (8 April 2013) Abstract \| Provisional PDF \| PubMed
	18. 221 Accesses	Research article Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions Silvia Jordans, Saša Jenko-Kokalj, Nicole M Kühl, Sofia Tedelind, Wolfgang Sendt, Dieter Brömme, Dušan Turk, Klaudia Brix BMC Biochemistry 2009, 10:23 (22 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cathepsin cysteine proteases are active under conditions simulating extracellular and intracellular compartments with a range of pHs and redox potentials, as shown by cleavage of the natural substrate thyroglobulin in distinct ways in different physiologic environments.
	19. 213 Accesses	Research article Regulation of the BRCA1 gene by an SRC3/53BP1 complex Dale Corkery, Gobi Thillainadesan, Niamh Coughlan, Ryan D Mohan, Majdina Isovic, Marc Tini, Joseph Torchia BMC Biochemistry 2011, 12:50 (13 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The tumor suppressor 53BP1 and the oncogene SRC3 occupy the same region of the BRCA1 promoter and are both required for BRCA1 expression, suggesting that this complex plays an important role in DNA repair and genomic stability
	20. 213 Accesses	Research article Acetylcholinesterase assay for cerebrospinal fluid using bupivacaine to inhibit butyrylcholinesterase Wolfram H Kluge, Harald H Kluge, Heike I Bauer, Stefan Pietsch, Jens Anders, Rudolf A Venbrocks BMC Biochemistry 2001, 2:17 (21 December 2001) Abstract \| Full text \| PDF \| PubMed
	21. 207 Accesses	Research article Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails Ina Bock, Srikanth Kudithipudi, Raluca Tamas, Goran Kungulovski, Arunkumar Dhayalan, Albert Jeltsch BMC Biochemistry 2011, 12:48 (31 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	22. 205 Accesses	Research article Extraction and inhibition of enzymatic activity of botulinum neurotoxins /B1, /B2, /B3, /B4, and /B5 by a panel of monoclonal anti-BoNT/B antibodies Suzanne R Kalb, Wanda I Santana, Isin N Geren, Consuelo Garcia-Rodriguez, Jianlong Lou, Theresa J Smith, James D Marks, Leonard A Smith, James L Pirkle, John R Barr BMC Biochemistry 2011, 12:58 (15 November 2011) Abstract \| Full text \| PDF \| PubMed
	23. 205 Accesses	Research article Arg188 in rice sucrose transporter OsSUT1 is crucial for substrate transport Ye Sun, John M Ward BMC Biochemistry 2012, 13:26 (21 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Arginine-188 of the plant sucrose uptake transporter OsSUT1 is required for substrate translocation but not interaction, implicating the involvement of an alternative substrate binding site in substrate recognition.
	24. 200 Accesses	Research article Purification and characterization of cysteine protease from germinating cotyledons of horse gram Rajeswari Jinka, Vadde Ramakrishna, Sridhar K Rao, Ramakrishna P Rao BMC Biochemistry 2009, 10:28 (17 November 2009) Abstract \| Full text \| PDF \| PubMed
	25. 197 Accesses	Research article Enzymatic properties of Staphylococcus aureus adenosine synthase (AdsA) Vilasack Thammavongsa, Olaf Schneewind, Dominique M Missiakas BMC Biochemistry 2011, 12:56 (28 October 2011) Abstract \| Full text \| PDF \| PubMed