The music of the genes: Mark Jobling on the mysteries of musical talent

Posted by Biome on 30th January 2014 - 0 Comments


This article was written by Mark Jobling, professor of genetics at the University of Leicester, and originally published in Investigative Genetics.

 

The most famous of musical dynasties is that of the Bachs. In Leipzig for a conference, I visited the Bach Museum opposite the Thomaskirche where the greatest Bach of all worked as Kapellmeister for 27 years, and is now buried. There, the family’s many names are laid out on a wall, from Johann Sebastian’s great-great-grandfather Veit, a miller and player of the cittern, born around 1550, via J.S. himself, and on to his grandson Wilhelm Friedrich Ernst. One by one, the names light up, and as each Bach is illuminated his music fills the air.

The occurrence of so many great musicians in seven generations of one family might suggest musical ability in the genes. Francis Galton, in his Hereditary Genius (Galton F, London: Macmillan, 1869), studied musicians alongside judges, statesmen, scientists, commanders, authors, poets and artists, as one of his classes of ‘eminent men’ (note, no women). As well as these brainy and artistic types, he cast wrestlers and rowers into the mix, too. Galton investigated the pattern of inheritance of exceptional ability within families, showing that the eminence of relatives of an eminent man declined with the degree of relatedness, and taking this as evidence of heritability.

There are two difficulties with Galton’s approach to musical ability – the phenotype (general eminence) is complex and vaguely defined, and the influence of the environment is not accounted for. In the Bach family, for example, musical training at a young age was the norm, and clearly led to a good living, so alternative careers were not necessarily high on the agenda.

Modern geneticists have also been interested in questions of musical inheritance, and have mostly focused on a simpler phenotype, absolute pitch (AP) – the ability to instantly recognize and correctly name the pitch of any of about seventy different notes in the middle of the auditory range. The phenotype is generally rare, and found in only approximately 1 to 2 percent of music students and musical professionals, so is far from being a proxy for musicianship. Clearly, AP requires some prior exposure to notes and their names, and an ability to fix and recall these associations. Oliver Sacks, in a chapter of his book Musicophilia (Sacks O, London: Picador, 2007) entitled ‘Papa Blows his Nose in G’, points out that the real wonder of AP is that for people who possess it, each tone has its own unique characteristic (for example, F-sharp-ness), which to them is often analogous to colour. Indeed, some composers, including Scriabin and Messiaen, explicitly linked notes and colours, possible examples of synesthesia, in which one kind of sensory stimulus evokes another.

AP is a complex trait, involving both genetic and environmental factors: musical training during early development contributes to its acquisition, and it is more frequent in Asians than Europeans, a finding that some have attributed to early exposure to languages in which tone is particularly important. Genome-wide linkage analysis (Hum Mol Genet. 2013, 22:2097-2104) in families showing both AP and synesthesia highlighted a shared region on chromosome 6, supporting the relationship between these phenotypes. Subsequent sequencing of candidate genes revealed otherwise rare amino-acid-changing variants in affected members of four families in EPHA7, a gene encoding a member of a family of cell-surface-bound receptor tyrosine kinases that may play an important role in neural differentiation and connectivity in the developing brain.

One particular genetically defined group appears to exhibit a high natural ability for music. These are people with Williams-Beuren syndrome (WBS) (N Engl J Med. 2010, 362:239-252). Carrying a 1.5 to 1.8 Mb deletion on the long arm of chromosome 7 that removes 26 to 28 genes, subjects suffer from a constellation of abnormalities, with a mean IQ of 55, and severe difficulties in spatial tasks such as solving jigsaw puzzles. However, there are compensating strengths in musical ability, with many showing skill in singing or playing instruments. There is disagreement about the incidence of absolute pitch in WBS: in a study by neuroscientist Howard Lenhoff (Music Percep. 2001, 18:491-503), five young WBS subjects all had AP, but a more recent larger study has failed to find a convincing association (Child Neuropsychol. 2013, 19:78-96). Lenhoff’s own daughter, Gloria, has WBS and is a musical savant, singing almost 2,000 songs in many languages from memory, and performing with renowned orchestras.

As well as phenotypes that enhance musical abilities, there are some that do the opposite. Congenital amusia (or tone deafness) is the failure to acquire the perception and recognition of music, despite having normal hearing, language, and intelligence. One patient seen by Sacks (Sacks O, London: Picador, 2007) could not recognize ‘Happy Birthday to You’, even though, as a school-teacher, she was obliged to play a recording of it at least 30 times a year. To her, the sound of music was ‘like pots and pans being thrown on the floor’. Family studies (Am J Hum Genet. 2007, 81:582-588) show a genetic component, since 39 percent of first-degree relatives of subjects have amusia, compared to a population frequency of about 4 percent, but no gene hunts have yet been undertaken.

Setting aside these unfortunate tone-deaf cases, music is a cultural universal, and findings of prehistoric bone flutes in southern Germany show that humans have been making sophisticated music for at least 42,000 years (Nature. 2009, 460:737-740 & J Hum Evol. 2012, 62:664-676). But what is it all for? Darwin believed that music evolved through sexual selection; by analogy with birds and their songs, the creation and appreciation of music was part of the complex process of attracting the opposite sex. ‘Music has a wonderful power […] of recalling in a vague and indefinite manner, those strong emotions which were felt during long-past ages, when, as is probable, our early progenitors courted each other by the aid of vocal tones’ (Darwin C, London: John Murray, 1872). In Darwin’s opinion, language came after music. Herbert Spencer disagreed, claiming that music arose naturally from the cadences used in emotional speech. In modern times, Steven Pinker (Pinker S, London: Penguin, 1997) has sided with Spencer, arguing that music is simply a useless by-product of language (‘auditory cheesecake’). Steven Mithen (Mithen S, London: Weidenfeld & Nicolson, 2005), however, believes that music is too different from language to be a by-product, and that its emotional power indicates a long and important evolutionary history. A consensus seems unlikely to emerge any time soon.

The Leipzig conference in which I participated was concerned with language, and I learned that linguists disagree violently about some fundamental aspects of what modern languages can tell us about populations in the distant past. Funnily enough, music might help here. Analysing characters such as rhythm, pitch and dynamics in traditional vocal songs from nine indigenous populations of Thailand (Proc R Soc B. 2014, 281:20132072) allows a music-based distance measure to be calculated between them. Comparison of this to analogous distances based on languages and genetics (using maternally inherited mitochondrial DNA) shows that music is a better fit to genetics than language is. Likewise, a geographically broader study of Eurasian populations (Mol Genet Genomics. 2012, 287:337-349) shows that high musical similarity predicts high genetic similarity, and that the relationship is stronger for maternal than for paternal lineages.

Perhaps, then, musicology could replace historical linguistics as a tool to find cultural connections that reflect deep shared ancestry – the language changes, but (like the legacy of Bach) the melody lingers on. Mothers sing to their babies, after all.

 

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The music of the genes

Jobling MA
Investigative Genetics 2014, 5:2

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