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Antibiotic treatments: are patients willing to wait?

The rise of antibiotic resistant bacteria poses a great threat to human health; one of the main causes is antibiotic overuse

Crystal structure of the MET receptor (yellow, orange) in complex with bacterial ligand internalin B used by Listeria monocytogenes (purple, cyan) to infect normally non-phagocytic host cells. Image source: Dietz et al, BMC Biophysics  2013, 6:6. Crystal structure data: RSCB PDB file 2UZY.

To bind or not to bind: intricacies of ligand-induced receptor dimerization

For a receptor to become active, the ligand must bind to two domains. Do the domains exist as two inactive monomers, single preformed dimers or both?

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Viral beginnings: Virophages allude to a network-like evolution of viruses

Phylogenomic analysis of known virophages provides insight into the evolution of virophages as well as viruses as a whole.

Flower of the Liriodendron Tulipifera. (C) wlcutler (flickr)

Unearthing a mitochondrial ‘fossil’

The oldest living organism in New York City is said to be a tulip tree (Liriodendron tulipifera) and it now has a new claim for extraordinary agedness

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Clues to kidney cancer growth revealed by metabolomics of the urea cycle

A recent study in Cancer & Metabolism revealed unexpected metabolic changes caused by loss of fumarate hydratase activity in kidney cancer.

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Squished bug genomics: insect goo aids biodiversity research

A new approach to studying biodiversity from a team at BGI Shenzhen gives first insights into how poorly characterized local insect communities are.

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Exercise training program ameliorates cardiovascular effects of childhood SLE

A supervised exercise training program safely and effectively ameliorates cardiovascular effects of childhood-onset Systemic Lupus Erythematosus

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Does DNA methylation repress gene expression?

Richard Meehan, Wendy Bickmore and colleagues show that an intact DNA methylome is required for Polycomb-mediated gene repression.

Molecular model of methane monooxygenase, which once activated by metal ions provided by the methanobactins, can promote the metabolism of methane.

Methanobactins: more about metal than methane?

A genome mining study highlights genes involved in the production of methanobactin, which are important for copper-uptake in methanotrophs, but also suggests that not all of these bacteria have them.

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Moderate exercise can improve fatigue in fibromyalgia

Aerobic exercise can reduce fatigue in individuals with fibromyalgia in a BMI- linked manner, with leaner individuals reporting benefits sooner.