When function isn’t always ‘function’ for non-coding RNAs
Pauler and colleagues highlight cases where the transcription of non-coding RNA, rather than the ncRNA itself, may be the key functional element
The upSET over non-coding RNAs: how chromatin structure governs their production
Transcription can be initiated from multiple transcription start sites to produce non-coding RNAs via a tightly regulated process
The epigenetics of rheumatic disease
An increasing number of studies have described alterations of epigenetic mechanisms in inflammatory rheumatic diseases.
5hmC: roles for the ‘6th DNA base’ in development and cancer?
5-hydroxymethylcytosine (5hmC) is a stable DNA base that appears regularly in the mammalian genome, yet its function remains elusive.
Introns: the best thing since spliced bread
Sixty years since Watson and Crick’s double helix DNA structure was published, Genome Biology asks their Editorial Board to name what they think are the most important discoveries and inventions in the field
Podcast: Raymond Gosling – the road to the double helix
Raymond Gosling, a key player on the road to the discovery of the structure of DNA, shares his memories of the race to the double helix in a Genome Biology Editorial
The forging of a cancer-metabolism link and twists in the chain
Grahame Hardie and Dario Alessi look back at developments since discovering a link between the metabolic regulator AMPK and the tumor suppressor LKB1.
Profiling schizophrenia: insights from proteomics
A review in Genome Medicine highlights how proteomics has aided understanding of the pathways involved in schizophrenia, with a view towards new therapies.
What we still don’t know about biology
BMC Biology asks their Editorial Board about the pressing, or just interesting, open questions in their fields.
Medicine for global health
A thematic series in BMC Medicine focussing on public health initiatives, health care policies and evidence-based guidelines towards global health.
