• Top
• Introduction
• Structure
• References

Introduction

Pharmacokinetics (PK) today is an established discipline in drug development and pharmaceutical research. For optimum therapeutic use of any drug it is essential to know its fate in the body after administration and to characterize its disposition. For this purpose there are two different approaches that have evolved in pharmacokinetics which either assume the existence of kinetic compartments ('compartmental pharmacokinetics') or do not ('non-compartmental pharmaco-kinetics'). This practical workshop provides an introduction to applied compartmental and non-compartmental pharmacokinetics. The workshop is focused at the presentation of methods used in pharmacokinetic data analysis. Standardized methods are proposed and presented with practical examples. All pharmacokinetic parameters are clearly defined, and methods for their determination are presented.

Structure

The workshop is organised to focus on the following items: Physiological model of PK; Drug concentration and directly derived parameters; Types of elimination / Mechanisms of transports; Compartmental model / Mathematical model; Bioavailability (absolute and relative); Bioequivalence; Factors influencing bioavailability; Dose proportionality, PK parameters Clearance, Area under the curve, C_max, t_max, Half life.

References

1. Pharmakokinetik.

   Wissenschaftliche Verlagsgesellschaft mbH Stuttgart(Edited by: Derendorf H, Gramatté T, Schäfer HG). 2002.

2. Parameters for Compartment-free Pharmacokinetics.

   Shaker Verlag(Edited by: Cawello W). 2003.

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