How is epigenetic information maintained through generations?

As part of the Epigenetics & Chromatin conference article collection, Jessica Tyler and colleagues discuss mechanisms of how the epigenetic landscape is continued through DNA replication.

Heterogeneous genetic origins of CAS

Whole exome sequencing (WES) of individuals with Childhood Apraxia of Speech (CAS) suggests that CAS is genetically heterogeneous, and that WES could have a potential role in the clinical and genetic diagnosis of pediatric motor speech disorders.

Low transmission potential of H7N9

Mathematical models suggest the novel influenza A/H7N9 virus has low transmission potential in China, but continued monitoring is warranted as changing seasonal factors and relaxed interventional measures might promote its spread.

Umbilical cord stem cells for IVD therapy?

Human umbilical cord stem cells can differentiate into cells exhibiting an immature nucleus pulposus phenotype in a laminin-rich culture environment, and may have therapeutic potential in intervertebral disc (IVD) degeneration.

Mobile DNA in the butterfly genome

The first analysis of transposable elements in a butterfly genome is presented and compared with a moth genome, providing insights into transposable element evolution within the Lepidoptera order.

Identifying gaps in breast cancer research

Current knowledge 'gaps' in the understanding of breast cancer are examined, and research should focus on these to improve future clinical care.

Signaling cell fate in cancer cells

In this important study to help understand the bimodal function of PKA, Hedrick et al present their findings regarding differential activation of PKA and the role of AKAPs in cell survival decisions.

New tool improves communication in ICU

A new tool, Psychosocial Assessment and Communication Evaluation (PACE), shows promising results in improving communication and palliative care for both patients and their families during clinical uncertainty in intensive care units (ICU).

Hypothyroidism increases COPD exacerbations

Increased levels of thyroid stimulating hormone (TSH) in patients with COPD comorbid with hypothyroidism indicate increased frequency of COPD exacerbations, suggesting that detection and management of thyroid conditions could help improve quality of life in COPD patients.

Tetracycline resistance in the African camel

Anne Fischer and colleagues analysed Streptococcus agalactiae populations in the African camel and found widespread tetracycline resistance, associated with acquisition of the gene tetM carried on a Tn916-like element.