Epigenetic variation in twin-twin transfusion syndrome

An examination of global and gene specific DNA methylation patterns in children with twin-twin transfusion syndrome, a complication of disproportionate blood supply.

Improved maternal care needed in LMICs

In a clinical trial, interventions based on birth planning, hospital transport and staff training do not reduce perinatal mortality in low- and middle-income countries (LMICs), suggesting more resources are needed to improve obstetric care systems.

Light at night reduces melatonin production in urban birds

Urban birds are active earlier in the day due to the suppression of melatonin production, which is a result of increased light levels at night in urban environments. This suggests that urban birds could become desynchronized with the light-dark cycle which affects daily behaviour as well as annual breeding cycles.

Heterogeneous genetic origins of CAS

Whole exome sequencing (WES) of individuals with Childhood Apraxia of Speech (CAS) suggests that CAS is genetically heterogeneous, and that WES could have a potential role in the clinical and genetic diagnosis of pediatric motor speech disorders.

Low transmission potential of H7N9

Mathematical models suggest the novel influenza A/H7N9 virus has low transmission potential in China, but continued monitoring is warranted as changing seasonal factors and relaxed interventional measures might promote its spread.

Mobile DNA in the butterfly genome

The first analysis of transposable elements in a butterfly genome is presented and compared with a moth genome, providing insights into transposable element evolution within the Lepidoptera order.

How is epigenetic information maintained through generations?

As part of the Epigenetics & Chromatin conference article collection, Jessica Tyler and colleagues discuss mechanisms of how the epigenetic landscape is continued through DNA replication.

Umbilical cord stem cells for IVD therapy?

Human umbilical cord stem cells can differentiate into cells exhibiting an immature nucleus pulposus phenotype in a laminin-rich culture environment, and may have therapeutic potential in intervertebral disc (IVD) degeneration.

Identifying gaps in breast cancer research

Current knowledge 'gaps' in the understanding of breast cancer are examined, and research should focus on these to improve future clinical care.

Tetracycline resistance in the African camel

Anne Fischer and colleagues analysed Streptococcus agalactiae populations in the African camel and found widespread tetracycline resistance, associated with acquisition of the gene tetM carried on a Tn916-like element.