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  • Eye disorders in golden retrievers linked to novel mutation in TTC8

    The authors use whole genome scanning to identify an association between the gene TTC8 and inherited eye disorders in golden retrievers. A single mutation in TTC8 was found by DNA sequencing, and then confirmed by screening a larger number of dogs.

    Canine Genetics and Epidemiology 2014, 1:4
  • Genetics of eye disorders in the dog

    Cathryn Mellersh looks at the mutations that have been associated with inherited eye disorders in the dog. Similarities between eye structure and disease in humans and dogs point to an increased role for dogs in helping us to understand and treat eye disorders in both species.

    Canine Genetics and Epidemiology 2014, 1:3
  • Approaches to canine health surveillance

    Authors at the Royal Veterinary College and the University of Sydney review the history and development of health surveillance systems in canine medicine. These systems each have their own strengths and weaknesses when it comes to monitoring dog health.

    Canine Genetics and Epidemiology 2014, 1:2
  • Every dog has its day: a new journal for canine genetics and epidemiology

    We are delighted to announce the launch of Canine Genetics and Epidemiology, an open access journal published by BioMed Central with the support and backing of the UK Kennel Club.

    Canine Genetics and Epidemiology 2014, 1:1
  • Image attributed to: NASA, Wikimedia Commons

    African microbiome research

    Leading researchers present their recommendations for harnessing microbiome and probiotic research in Sub-Saharan Africa.

    Microbiome 2014, 2:12
  • Image attributed to: From Rico et al.

    Gene expression in patient-derived xenografts

    Transcriptomic analysis shows for the first time that patient-derived xenografts in mice are more closely related to primary tumors than cell lines are for pancreatic tumors.

    Genome Medicine 2014, 6:27
  • VMCL vaccination for metastatic melanoma

    Prolonged, repeated Vaccinia Melanoma Cell Lysate vaccination immunotherapy appears to be a clinically effective means of generating high Complete Response rates and long-term survivals, which could be explained by successive immunomodulation

    Journal for ImmunoTherapy of Cancer 2014, 2:9
  • Performance on a pattern separation task

    A pattern separation test in mild to moderate Alzheimer’s disease patients suggests a possible genetic link to poor hippocampal neurogenesis, with performance related to apolipoprotein ϵ4 status and cerebrospinal fluid amyloid-β42 levels.

    Alzheimer's Research & Therapy 2014, 6:20
  • HDAC inhibitors in tumor control

    The histone deacetylase inhibitor,  LBH589 increases the in vivo antitumor response of adoptive T cell therapy by creating a favourable cytokine response and increased expansion of polyfunctional T cells

    Journal for ImmunoTherapy of Cancer 2014, 2:8
  • Image attributed to: istock

    Orthogeriatric care improves mobility

    In a randomized trial, perioperative orthogeriatric care does not reduce delirium and cognitive decline in hip fracture patients, but has a positive effect on mobility, highlighting a need for integration of orthopedic and geriatric services.

    BMC Medicine 2014, 12:63
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