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  • Image attributed to: flick cc Rosino

    More research needed for dementia care

    There is a high prevalence of comorbid conditions in people with dementia; evidence from a scoping review suggests there is a need for more research into how dementia impacts healthcare, as well as patient involvement in clinical decision making.

    BMC Medicine 2014, 12:192
  • Image attributed to: Sara Booth;

    Intervention aids breathlessness management

    In a randomised trial, patients with advanced cancer receiving the multidisciplinary Breathlessness Intervention Service (BIS) have lower levels of distress than those being given standard care, highlighting the promise of BIS for palliative care.

    BMC Medicine 2014, 12:194
  • Rodent malaria genomics

    Plasmodium parasites that infect rodents are promising laboratory models for human malaria, but our ability to interrogate their biology has been limited by a scarcity of genomic data. As a comprehensive resource for future research, Otto and colleagues have generated a wealth of genomic, transcriptomic and genotype diversity data.

    BMC Biology 2014, 12:86
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    TB active case finding is cost-effective

    In a modeling study, active case finding (ACF) for tuberculosis (TB) is highly cost-effective in India, China and South Africa, and long-term gains outweigh high initial costs, highlighting that ACF should be considered as a tool for TB control.

    BMC Medicine 2014, 12:216
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    Inappropriate antibiotics for sepsis

    Carbapenem-resistant Acinetobacter spp. sepsis patients in the ICU are at risk of inappropriate initial antibiotic therapy, a predictor of hospital mortality, indicating the need for novel diagnostic tools and concerted efforts to prevent the spread of resistant organisms

    BMC Infectious Diseases 2014, 14:572
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    Medical education reporting

    Rachel Ellaway comments on the recently published STructured apprOach to the Reporting In healthcare education of Evidence Synthesis (STORIES) statement, highlighting that it will enable research to be translated into medical education practice.

    BMC Medicine 2014, 12:193
  • RNA polymerase crosstalk

    RNA polymerase III complexes, when bound to DNA, regulate RNA polymerase II transcription of neighboring genomic regions.

    BMC Biology 2014, 12:89
  • Image attributed to: Flickr (CC, Lars Ploughman)

    Triple P program has short-term advantages

    In a randomized controlled trial, the parenting support program Stepping Stones Triple P effectively reduces psychosocial problems in children with disabilities over a 3 month period, but not after 6 months, suggesting short-term benefits of the program.

    BMC Medicine 2014, 12:191
  • Image attributed to: From Fig 1 of Hrdlickova and colleagues

    ‘Guilt by association’ in AID

    Genome-wide association studies mapped 90% of loci linked to autoimmune and immune-related diseases to non-coding regions.  A ‘guilt by association’ approach suggests a role for lncRNAs in autoimmunity.

    Genome Medicine 2014, 6:88
  • Image attributed to: Image credit: Baum and Baum, BMC Biology 2014

    Inside-out origins - how eukaryotes began

    How far could a proto-eukaryote have got before it swallowed its proto-mitochondria? Not far enough to provide the energy for phagocytosis to swallow them, say David and Buzz Baum, who have developed an alternative to the accepted theory for the origin of eukaryotes

    BMC Biology 2014, 12:76
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