Ben Goldacre and colleagues review why the current guidelines to prescribe anti-psychotics for treatment-resistant OCD may not be the best strategy.
Jean-François Timsit and colleagues review the main elements that should be taken into account when treating bloodstream infections in ICU patients, such as the patient's prior antibiotic use and source of the infection.
Analysis of nine Corynebacterium ulcerans isolates from human patients and their domestic animals by next generation sequencing suggests a zoonotic transmission and reveals a putative novel virulence factor.
A method based on whole genome sequencing can detect phase variation, a genomic diversification mechanism used by bacteria to adjust to stressful environments such as the presence of antibiotics.
Patients with non-celiac wheat sensitivity (NCWS) have higher incidence of osteoporosis than those with irritable bowel syndrome, and bone mass loss is associated with low body mass index, highlighting the need for dietary support in NCWS patients.
Striking conservation across jawed vertebrates is seen at the cis-regulatory level in the homeodomain transcription factor orthopedia (Otp) gene, involved in the regulation of hypothalamic neurons that are responsible for the stress response.
Oral testosterone replacement therapy (TRT) leads to significant cardiovascular (CV) risk, whereas injected or transdermal TRT do not, which could be due to the different routes of administration, which might affect serum dihydrotestosterone.
Evidence from a systematic review and meta-analysis of over 30 million births indicates that the risk of stillbirth in males is around 10% higher than in females, suggesting further research is required to understand the cause of excess male risk.
Blood transcriptional profiling of patients with sepsis, including survivors and non-survivors, reveals survival is associated with a strong immune response and with missense variants in VPS9D1.
Zinc protoporphyrin (ZPP) measured in blood has limited ability to identify iron deficiency in Kenyan pregnant women, and cannot reliably rule out the condition, suggesting that guidelines on the use of ZPP to assess iron status require revision.
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