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    Revisiting OCD treatment

    Ben Goldacre and colleagues review why the current guidelines to prescribe anti-psychotics for treatment-resistant OCD may not be the best strategy.

    BMC Psychiatry 2014, 14:317
  • Image attributed to: Calleamanecer on Wikipedia

    How to best treat bloodstream infections in the ICU

    Jean-François Timsit and colleagues review the main elements that should be taken into account when treating bloodstream infections in ICU patients, such as the patient's prior antibiotic use and source of the infection.

    BMC Infectious Diseases 2014, 14:489
  • Image attributed to: Detail of Figure 3_from Meinel et al.

    C. ulcerans transmission and virulence

    Analysis of nine Corynebacterium ulcerans isolates from human patients and their domestic animals by next generation sequencing suggests a zoonotic transmission and reveals a putative novel virulence factor.

    Genome Medicine 2014, 6:113
  • Image attributed to: Detail of Figure 1_from Goldberg et al.

    Detection of phase variation in bacteria

    A method based on whole genome sequencing can detect phase variation, a genomic diversification mechanism used by bacteria to adjust to stressful environments such as the presence of antibiotics.

    Genome Medicine 2014, 6:112
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    Wheat sensitivity linked to bone loss

    Patients with non-celiac wheat sensitivity (NCWS) have higher incidence of osteoporosis than those with irritable bowel syndrome, and bone mass loss is associated with low body mass index, highlighting the need for dietary support in NCWS patients.

    BMC Medicine 2014, 12:230
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    Conserved cis-elements for stress response

    Striking conservation across jawed vertebrates is seen at the cis-regulatory level in the homeodomain transcription factor orthopedia (Otp) gene, involved in the regulation of hypothalamic neurons that are responsible for the stress response.

    BMC Developmental Biology 2014, 14:41
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    Oral testosterone leads to CV risk

    Oral testosterone replacement therapy (TRT) leads to significant cardiovascular (CV) risk, whereas injected or transdermal TRT do not, which could be due to the different routes of administration, which might affect serum dihydrotestosterone.

    BMC Medicine 2014, 12:211
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    Stillbirth risk higher in males

    Evidence from a systematic review and meta-analysis of over 30 million births indicates that the risk of stillbirth in males is around 10% higher than in females, suggesting further research is required to understand the cause of excess male risk.

    BMC Medicine 2014, 12:220
  • Image attributed to: Detail of Figure 3_from Tsalik et al.

    Expressed variants and sepsis outcomes

    Blood transcriptional profiling of patients with sepsis, including survivors and non-survivors, reveals survival is associated with a strong immune response and with missense variants in VPS9D1.

    Genome Medicine 2014, 6:111
  • Image attributed to: istock photo

    Protein unreliable to detect iron status

    Zinc protoporphyrin (ZPP) measured in blood has limited ability to identify iron deficiency in Kenyan pregnant women, and cannot reliably rule out the condition, suggesting that guidelines on the use of ZPP to assess iron status require revision.

    BMC Medicine 2014, 12:229
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