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  • Germline epigenome reprogramming

    Epigenetic effects of endocrine disrupting chemicals in germ cells are corrected by germline reprogramming events in the next generation

    Genome Biology 2015, 16:59
  • Diagnosing and managing PCOS

    In this podcast, Richard Legro, an obstetrician and gynecologist, answers our questions on the diagnosis and treatment of polycystic ovary syndrome (PCOS) and highlights the controversies associated with therapies for infertility in PCOS.

    BMC Medicine 2015, 13:64
  • Image attributed to: wikimedia commons-Jeff Weiss

    Host immunity determines influenza virus infection

    Diverse clinical response to two strains of influenza virus in ferrets demonstrated that host immunity, not the virus strain, was the determinant in the outcome of influenza virus infection. 

    Virology Journal 2015, 12:48
  • Image attributed to: istock photo

    Breast cancer chemoprevention

    Evidence from randomized trials suggests that taking selective estrogen receptor modulators could reduce breast cancer risk; Victor Vogel comments on the latest results, recommending that the risks and benefits should be considered for each individual.

    BMC Medicine 2015, 13:63
  • Image attributed to: Harten, BMC Biology 2015

    Genome-wide activity of an epigenetic modifier

    Emma Whitelaw and colleagues explore the genome-wide consequences of the absence of a recently-identified epigenetic modifier, reporting effects on methylation at thousands of loci in embryonic mice, with a bias towards activity at CpG island shores and enhancers.

    BMC Biology 2015, 13:21
  • Making rare diseases visible

    Following revision of the International Classification of Diseases, the European Commission Expert Group on Rare Diseases recommends health care coding systems to use ORPHA codes in addition to ICD10 codes for rare diseases.

    Orphanet Journal of Rare Diseases 2015, 10:35
  • Genome-to-phenome with FAANG

    The FAANG Consortium introduces a new project to produce comprehensive maps of functional elements in the genomes of domesticated animal species.

    Genome Biology 2015, 16:57
  • Lumbar transversus abdominis plane block: the role of local anesthetic volume and concentration

    Lack of consensus surrounds the efficacy and optimal use of lumbar transversus abdominis plane block for multimodal analgesia following abdominal surgeries. Pilot results show a full-scale RCT to evaluate anesthetic volumes on cephalad dermatomal blockade would be feasible.

    Pilot and Feasibility Studies 2015, 1:10
  • MicrobeCensus

    MicrobeCensus is a method for estimating average genome size from shotgun metagenomic data based on single-copy gene families

    Genome Biology 2015, 16:51
  • MUSiCC

    MUSiCC is a method for normalizing metagenomic data, based on the abundances of a panel of universal single-copy genes

    Genome Biology 2015, 16:53
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