Immunocompromised patients are at higher risk of contracting tuberculosis with atypical presentations. A 17 year-old man presented with focal fits progressing to epilepsia partialis continua. Mycobacterium tuberculosis was detected in the cerebrospinal fluid and successfully treated.
A method for predicting a sequence’s localization in the A or B compartment of the nucleus based on chromatin data
Part of a series on bioinformatics and systems biology in radiation oncology, this review looks at the promise of next-generation sequencing for developing personalised cancer treatment strategies.
In a systematic review, the inattentive component of attention deficit/hyperactivity disorder (ADHD) has a stronger negative association with mathematical ability than the hyperactive component, highlighting that ADHD domains could have differential etiology.
Transient pharmacological inhibition of DNA-PKcs can stimulate homology-directed repair following Cas9-mediated induction of a double strand break, and is expected to reduce the downstream workload.
A new technique borrows from biomedical engineering to study plant cells in culture conditions that mimic tissue scaffolds, allowing for a more physiologically relevant way to explore cell-environment interactions.
A comparison of in-nucleus and in-solution ligation protocols for Hi-C finds that the former gives much more consistent results
The presence of rheumatoid factor (RF) has a clear association with high levels of disease activity in rheumatoid arthritis (RA) patients whereas autoantibodies against citrullinated proteins (APCA), the characteristic marker, does not.
Robin Allaby discusses the origins of barley, and what this means for our understanding of the evolution of domesticated crops
Does the state of the brain - whether asleep, awake, or sleep-deprived - affect astrocytes (or vice versa)? Profiling of ribosome-associated mRNAs identifies changes in gene expression, while 3-d imaging at nanometer resolution reveals a retraction of astrocytic processes from neural synapses during sleep.
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