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  • Inter-hospital transfer and mortality in AKI patients

    Inter-hospital transfer of critically ill patients with acute kidney injury (AKI) does not increase risk of death or dialysis dependence 30 days after the initiation of acute renal replacement therapy.

    Critical Care 2014, 18:513
  • Image attributed to: Flickr: Caro Wallis

    Goals for sugar intake should be revised

    There is a log-linear relationship of caries to sugar intake from 0% of energy intake (E) to 10%E sugar at where a costly burden of caries is induced, suggesting public health goals should set sugar intakes ideally less than 3%.

    BMC Public Health 2014, 14:863
  • Image attributed to: MDougM, Wikimedia Commons

    Metabolism and angiogenesis

    Peter Carmeliet reviews how metabolic pathways in endothelial cells regulate angiogenesis during cancer development, providing a hugely useful resource for the cancer metabolism field

    Cancer & Metabolism 2014, 2:19
  • Bronchial epithelial cells in Z-AATD COPD

    Bronchial epithelial cells (BECs) from patients with Z variant alpha-1 antitrypsin (Z-AAT) deficiency, express and secrete Z-AAT and its polymers, suggesting that these cells are involved in the pathogenesis of emphysema and BEC dysfunction.

    Respiratory Research 2014, 15:112
  • Evaluating the Y chromosomal timescale

    The Y-chromosome can be used for paternal demographic and lineage dating, however owing to naturally occuring mutations, results can be incaccurate. Looking into a solution for one of the biggest problems in Y-chromosome phylogenetic studies.

    Investigative Genetics 2014, 5:12
  • Image attributed to: Mitou et al. International Journal of Plant Genomics (CC-BY)

    Targeting autophagy in cancer

    Eileen White discusses how cancer cells use autophagy to survive in low nutrient conditions and how new drugs targeting this process can be used to treat cancer.

    Cancer & Metabolism 2014, 2:14
  • Image attributed to: Wikipedia;ObwiedniaPeptydu

    Searching for cancer biomarkers

    Whole exome and whole genome sequencing has revealed specific mutations for various cancers, and so Eleftherios Diamandis suggests that the combination of genomics and proteomics may help to identify and develop clinically useful biomarkers.

    BMC Medicine 2014, 12:156
  • Histone marks: an alternative form of protection for sperm

    Repression of mobile genetic elements is essential for the survival of germ cells. A new pathway for silencing LINE-1 elements is described by Donal O'Carroll and colleagues.

    Epigenetics & Chromatin 2014, 7:24
  • Image attributed to: Figure 7

    BMP7's role in branching

    Transition from the initial wide branching urinary collecting duct tree to narrower later branching is dependent on the proximity of other branch tips with bone morphogenetic protein 7 (BMP7) acting as a repelling molecule in this process.

    BMC Developmental Biology 2014, 14:35
  • Image attributed to: Stefan Laube, Public Domain

    Slothful trends in evolution

    While existing sloth species have relatively small body sizes, a phylogenetic analysis that includes fossil species suggests this is unrepresentative of long-term evolutionary trends in this group which were towards larger and larger body sizes.

    BMC Evolutionary Biology 2014, 14:184
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