Palvimo and colleagues demonstrate that SUMOylation of chromatin-bound proteins represses heat shock-induced gene transcription
A comprehensive comparison of 11 tools for transcript isoform quantification using simulated data and experimentally derived data from RNA-seq and A-seq protocols
The production of interferons that provide the first line of defence against viruses is activated by elaborate little cytoplasmic machines containing ATP-driven helicases that can distinguish viral double-stranded RNA from double-stranded RNA segments of host origin. Denis Gerlier and colleagues shed new light on how this exquisite sensitivity is achieved
Troponin I concentration at hospital admission and after 3 hours identifies acute coronary syndrome (ACS) in patients with chronic atrial fibrillation, suggesting that measuring troponin kinetics could provide useful diagnostic information.
In this forum article, specialists working in malaria research, control and treatment discuss ways in which the disease could be eradicated, explaining how multi-disciplinary and collaborative processes are needed to make eradication a reality.
In a meta-analysis, the Pima CD4 analyzer is sensitive at 350 and 500cells/µl thresholds using capillary and venous derived samples respectively, adding to evidence regarding its use in point-of-care testing for antiretroviral therapy (ART) eligibility.
A clinical omics analysis pipeline using the Workflow Instance Generation and Specialization (WINGS) semantic workflow platform demonstrates transparency, reproducibility and analytical validity.
Iain Frame and Sarah Cant from Prostate Cancer UK answer our questions about the current challenges in prostate cancer research and policy, and how these are being addressed.
A new method for single-cell poly(A)-independent RNA-seq unravels the circRNA landscape in mouse preimplantation embryos
In an effort to enhance the reproducibility of research, BioMed Central launches a trial checklist for authors and reviewers.
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