There is a high prevalence of comorbid conditions in people with dementia; evidence from a scoping review suggests there is a need for more research into how dementia impacts healthcare, as well as patient involvement in clinical decision making.
In a randomised trial, patients with advanced cancer receiving the multidisciplinary Breathlessness Intervention Service (BIS) have lower levels of distress than those being given standard care, highlighting the promise of BIS for palliative care.
Plasmodium parasites that infect rodents are promising laboratory models for human malaria, but our ability to interrogate their biology has been limited by a scarcity of genomic data. As a comprehensive resource for future research, Otto and colleagues have generated a wealth of genomic, transcriptomic and genotype diversity data.
In a modeling study, active case finding (ACF) for tuberculosis (TB) is highly cost-effective in India, China and South Africa, and long-term gains outweigh high initial costs, highlighting that ACF should be considered as a tool for TB control.
Carbapenem-resistant Acinetobacter spp. sepsis patients in the ICU are at risk of inappropriate initial antibiotic therapy, a predictor of hospital mortality, indicating the need for novel diagnostic tools and concerted efforts to prevent the spread of resistant organisms
Rachel Ellaway comments on the recently published STructured apprOach to the Reporting In healthcare education of Evidence Synthesis (STORIES) statement, highlighting that it will enable research to be translated into medical education practice.
RNA polymerase III complexes, when bound to DNA, regulate RNA polymerase II transcription of neighboring genomic regions.
In a randomized controlled trial, the parenting support program Stepping Stones Triple P effectively reduces psychosocial problems in children with disabilities over a 3 month period, but not after 6 months, suggesting short-term benefits of the program.
Genome-wide association studies mapped 90% of loci linked to autoimmune and immune-related diseases to non-coding regions. A ‘guilt by association’ approach suggests a role for lncRNAs in autoimmunity.
How far could a proto-eukaryote have got before it swallowed its proto-mitochondria? Not far enough to provide the energy for phagocytosis to swallow them, say David and Buzz Baum, who have developed an alternative to the accepted theory for the origin of eukaryotes
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