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  • Head injury leads immune system to attack brain

    Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration.

    Acta Neuropathologica Communications 2014, 2:143
  • Image attributed to: istock

    Can alcohol consumption predict IHD risk?

    Low alcohol consumption without heavy drinking reduces ischemic heart disease (IHD) risk, but episodic and heavy drinking have no beneficial effect, suggesting that average alcohol consumption measures are not sufficient to predict IHD risk.

    BMC Medicine 2014, 12:182
  • Video Q&A: global alcohol burden

    In this video Q&A, we interview Sir Ian Gilmore on the global burden of alcohol in terms of its scale and consequences relating to illness, and discuss the strategies that are addressing the problem.

    BMC Medicine 2014, 12:209
  • Image attributed to: Flickr CC (Fredrik Rubensson)

    Why do we accept alcohol risks?

    Despite the known harms of excessive alcohol consumption, it is considered an acceptable risk; Jürgen Rehm et al. explore this issue, finding that alcohol’s special status may be due to overestimation of its health benefits when consumed in moderation.

    BMC Medicine 2014, 12:189
  • Image attributed to: Alan Lopez

    Video Q&A: tobacco and mortality

    Alan Lopez, a global health expert and epidemiologist, answers our questions about global burden of tobacco-related mortality, highlighting ways in which countries could apply tobacco control measures to alleviate this burden.

    BMC Medicine 2014, 12:162
  • Image attributed to: David, Wikimedia Commons

    Aging, metabolism and cancer

    David Gius and colleagues review the evidence that sirtiuns are tumor suppressor proteins that regulate mitochondrial metabolism, thereby linking aging mechanisms with carcinogenesis

    Cancer & Metabolism 2014, 2:15
  • Image attributed to: pixabay

    PDE5 inhibitors have cardioprotective effects

    Phosphodiesterase type 5 (PDE5) inhibitors are commonly used to treat erectile dysfunction; evidence from a meta-analysis suggests that these drugs also protect against cardiac remodelling, indicating that they could be used to treat heart disease.

    BMC Medicine 2014, 12:185
  • Image attributed to: Image credit: Alice Plane, BMC Biology

    Cancer cell signaling: What goes wrong?

    As the latest addition to our series of Open Questions, Steven Wiley focuses on the feedback controls on cell signaling and proliferation, and the need to understand how they are disrupted in cancer cells.

    BMC Biology 2014, 12:88
  • Image attributed to: Tietew, Wikimedia Commons

    Emerging picornaviruses in Hong Kong

    Human parechovirus, Aichi virus and salivirus were found in fecal samples from children in Hong Kong with gastroenteritis, providing the first information on the epidemiology of these emerging viruses in this region.

    Virology Journal 2014, 11:182
  • Image attributed to: Wikipedia, CCMesserWoland

    Genes, environment & breast cancer

    Evidence suggests that gene-environment interactions could modify breast cancer risk; Olivia Fletcher and Frank Dudbridge discuss progress in elucidating these interactions, highlighting that further validation in large cohort studies is required.

    BMC Medicine 2014, 12:195
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