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  • Global chromatin SUMOylation

    Palvimo and colleagues demonstrate that SUMOylation of chromatin-bound proteins represses heat shock-induced gene transcription

    Genome Biology 2015, 16:153
  • Transcript isoform abundance

    A comprehensive comparison of 11 tools for transcript isoform quantification using simulated data and experimentally derived data from RNA-seq and A-seq protocols

    Genome Biology 2015, 16:150
  • Innate  immunity to viruses – how to recognize your enemy

    The production of interferons that provide the first line of defence against viruses is activated by elaborate little cytoplasmic machines containing ATP-driven helicases that can distinguish viral double-stranded RNA from double-stranded RNA segments of host origin. Denis Gerlier and colleagues shed new light on how this exquisite sensitivity is achieved

    BMC Biology 2015, 13:54
  • Image attributed to: istock photo

    Can troponin I predict ACS?

    Troponin I concentration at hospital admission and after 3 hours identifies acute coronary syndrome (ACS) in patients with chronic atrial fibrillation, suggesting that measuring troponin kinetics could provide useful diagnostic information.

    BMC Medicine 2015, 13:169
  • Image attributed to: iStock Photo

    Towards malaria eradication

    In this forum article, specialists working in malaria research, control and treatment discuss ways in which the disease could be eradicated, explaining how multi-disciplinary and collaborative processes are needed to make eradication a reality.

    BMC Medicine 2015, 13:167
  • Image attributed to: istock

    Pima CD4 analyzer useful for ART tests

    In a meta-analysis, the Pima CD4 analyzer is sensitive at 350 and 500cells/&#181l thresholds using capillary and venous derived samples respectively, adding to evidence regarding its use in point-of-care testing for antiretroviral therapy (ART) eligibility.

    BMC Medicine 2015, 13:168
  • Image attributed to: By apple2000

    Semantic workflow for clinical omics

    A clinical omics analysis pipeline using the Workflow Instance Generation and Specialization (WINGS) semantic workflow platform demonstrates transparency, reproducibility and analytical validity.

    Genome Medicine 2015, 7:73
  • Video Q&A: prostate cancer

    Iain Frame and Sarah Cant from Prostate Cancer UK answer our questions about the current challenges in prostate cancer research and policy, and how these are being addressed.

    BMC Medicine 2015, 13:166
  • SUPeR-Seq

    A new method for single-cell poly(A)-independent RNA-seq unravels the circRNA landscape in mouse preimplantation embryos

    Genome Biology 2015, 16:148
  • Better reporting for better research

    In an effort to enhance the reproducibility of research, BioMed Central launches a trial checklist for authors and reviewers.

    GigaScience 2015, 4:32
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