Susy Yusung and Jonathan Braun comment on a modeling study suggesting no molecular mimicry between measles antigens and inflammatory bowel disease (IBD), highlighting that the findings support the safety of pediatric MMR vaccines.
Peter Byass comments on new estimates for the global burden of liver cirrhosis mortality, highlighting the challenges of this analysis and discussing the ways in which the data could be used for risk-reduction strategies.
Hepatitis C virus (HCV) patients undergoing outpatient protease-inhibitor-based triple therapy can find the treatment physically, emotionally and socially draining, and need systematic support from specially trained professionals in symptom management.
Consent for clinical tumor sequencing in children is more dependent on emotional aspects than race or ethnicity, while genomic privacy concerns are low.
Screens in yeast can be used to identify conserved interactions with the mismatch repair pathway to provide new avenues for cancer therapy based on synthetic lethality.
Inter-hospital transfer of critically ill patients with acute kidney injury (AKI) does not increase risk of death or dialysis dependence 30 days after the initiation of acute renal replacement therapy.
There is a log-linear relationship of caries to sugar intake from 0% of energy intake (E) to 10%E sugar at where a costly burden of caries is induced, suggesting public health goals should set sugar intakes ideally less than 3%.
Peter Carmeliet reviews how metabolic pathways in endothelial cells regulate angiogenesis during cancer development, providing a hugely useful resource for the cancer metabolism field
Bronchial epithelial cells (BECs) from patients with Z variant alpha-1 antitrypsin (Z-AAT) deficiency, express and secrete Z-AAT and its polymers, suggesting that these cells are involved in the pathogenesis of emphysema and BEC dysfunction.
Repression of mobile genetic elements is essential for the survival of germ cells. A new pathway for silencing LINE-1 elements is described by Donal O'Carroll and colleagues.
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