Previous research suggested a need for increased prescribing of generic risperidone in Western Europe; Michael Berk and colleagues argue for a balance between cheapest drug use and optimal tailored care to ensure beneficial patient outcomes.
Although phenotypically identical, pericardial adipose tissue-derived stromal cells (ADSCs) in comparison to subcutaneous ADSCs were shown to exhibit potent differentiation towards cardiomyocytes and induced significant structural repair in the injured heart.
Epinephrine may be injected into the bone of anaphylactic children weighing under 15kg, implying that further research is needed to determine the appropriate needle length for pediatric patients.
Active vaccine AADvac1 validates the novel tau target revealed by monoclonal antibody DC8E8 by reducing Alzheimer's disease-type tau hyperphosphorylation by 95% in transgenic rats, and has now entered phase I clinical trials.
Monoclonal antibody DC8E8 disables a novel target on tau protein essential for its pathological function both in vitro and in vivo, and is a suitable candidate molecule for Alzheimer's disease immunotherapy.
Female mocker swallowtail butterflies show a remarkable variety of wing patterns, each mimicking a different poisonous butterfly species; a new study provides insights into the evolution of the supergene locus that makes these polymorphisms possible.
It is a challenge to assess whether rare and patient-specific mutations are cancer drivers. The algorithm DawnRank prioritizes altered genes on a single patient level.
In a randomized trial, a community-based intervention aiming to prevent intimate partner violence (IPV) and HIV-risk behaviors in Uganda successfully reduced acceptance and incidence of IPV, and is now being delivered in other communities.
A self-reported lack of physical activity was associated with shortened telomere length in early stage breast cancer survivors, suggesting a mechanism by which exercise can reduce cellular aging.
Jigisha Patel suggests current flaws within peer review systems in medical journals can be tackled by defining aims of peer review, offering training and recognition for reviewers, and providing readers with a way of identifying individual published articles that have been assessed by ‘trained’ reviewers.
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