Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration.
Low alcohol consumption without heavy drinking reduces ischemic heart disease (IHD) risk, but episodic and heavy drinking have no beneficial effect, suggesting that average alcohol consumption measures are not sufficient to predict IHD risk.
In this video Q&A, we interview Sir Ian Gilmore on the global burden of alcohol in terms of its scale and consequences relating to illness, and discuss the strategies that are addressing the problem.
Despite the known harms of excessive alcohol consumption, it is considered an acceptable risk; Jürgen Rehm et al. explore this issue, finding that alcohol’s special status may be due to overestimation of its health benefits when consumed in moderation.
Alan Lopez, a global health expert and epidemiologist, answers our questions about global burden of tobacco-related mortality, highlighting ways in which countries could apply tobacco control measures to alleviate this burden.
David Gius and colleagues review the evidence that sirtiuns are tumor suppressor proteins that regulate mitochondrial metabolism, thereby linking aging mechanisms with carcinogenesis
Phosphodiesterase type 5 (PDE5) inhibitors are commonly used to treat erectile dysfunction; evidence from a meta-analysis suggests that these drugs also protect against cardiac remodelling, indicating that they could be used to treat heart disease.
As the latest addition to our series of Open Questions, Steven Wiley focuses on the feedback controls on cell signaling and proliferation, and the need to understand how they are disrupted in cancer cells.
Human parechovirus, Aichi virus and salivirus were found in fecal samples from children in Hong Kong with gastroenteritis, providing the first information on the epidemiology of these emerging viruses in this region.
Evidence suggests that gene-environment interactions could modify breast cancer risk; Olivia Fletcher and Frank Dudbridge discuss progress in elucidating these interactions, highlighting that further validation in large cohort studies is required.
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