Impact of CNX-011-67 on islet insulin synthesis and β-cell stress. Post 72 h of treatments, RNA was isolated and expression of (A) PDX1, (B) INS1, (C) PPARα, (D) TXNIP and (E) CHOP mRNA expression were measured as described under Methods (N = 2, n = 4). Statistical analysis was performed by One-Way ANOVA with Dunnett’s post test correction (*p < 0.05, **p < 0.01 and ***p < 0.001).
Gowda et al. BMC Pharmacology and Toxicology 2013 14:28 doi:10.1186/2050-6511-14-28