## Table 2 |
||||||

Classification of opioid ligands based on their DMR agonist activity in the five distinct
cell lines |
||||||

Name |
HEK |
MOR |
DOR |
KOR |
SH-SY5Y |
Literature classification |

β-Funaltrexamine | off-target | Partial agonist | Partial agonist | Partial agonist | Mu antagonist | |

BNTX | off-target | off-target | off-target | off-target | off-target | Delta antagonist |

Dynorphin A (2–13) | off-target | Partial agonist | Partial agonist | Kappa agonist | ||

Etonitazenyl | off-target | Partial agonist | Partial agonist | Mu agonist | ||

ICI 199,441 | off-target | Full agonist | Partial agonist | Full agonist | Kappa agonist | |

Nociceptin (1–13) | off-target | Partial agonist | Partial agonist | ORL1 agonist | ||

α-Neoendorphin | Partial agonist | Full agonist | Full agonist | Full agonist | Kappa agonist | |

BRL-52537 | Partial agonist | Full agonist | Kappa agonist | |||

BUBUC | Partial agonist | Full agonist | Partial agonist | Partial agonist | Delta agonist | |

DADLE | Partial agonist | Full agonist | Partial agonist | Full agonist | Delta agonist | |

DALDA | Partial agonist | Full agonist | Mu agonist | |||

DAMGO | Full agonist | Partial agonist | Partial agonist | Full agonist | Mu agonist | |

DAMME | Full agonist | Full agonist | Partial agonist | Full agonist | Mu/Delta agonist | |

Deltorphin II | Partial agonist | Full agonist | Delta agonist | |||

DIPPA | Partial agonist | Partial agonist | Full agonist | Kappa antagonist | ||

DPDPE | Partial agonist | Full agonist | Partial agonist | Full agonist | Delta agonist | |

DSLET | Full agonist | Full agonist | Partial agonist | Full agonist | Delta agonist | |

DTLET | Full agonist | Full agonist | Partial agonist | Full agonist | Delta agonist | |

Dynorphin A (1–13) | Full agonist | Full agonist | Full agonist | Partial agonist | Kappa agonist | |

Dynorphin A (1–8) | Full agonist | Full agonist | Full agonist | Full agonist | Kappa agonist | |

Dynorphin B | Partial agonist | Full agonist | Full agonist | Full agonist | Kappa agonist | |

Endomorphin-1 | Partial agonist | Partial agonist | Partial agonist | Mu agonist | ||

Endomorphin-2 | Partial agonist | Partial agonist | Partial agonist | Full agonist | Mu agonist | |

(Leu5)-Enkephalin | Full agonist | Full agonist | Partial agonist | Full agonist | Mu/Delta agonist | |

(Met5)-Enkephalin | Full agonist | Full agonist | Partial agonist | Full agonist | Mu/Delta agonist | |

GR 89696 | Partial agonist | Partial agonist | Full agonist | Full agonist | Kappa agonist | |

ICI 204,448 | Partial agonist | Partial agonist | Full agonist | Full agonist | Kappa agonist | |

Levallorphan | Partial agonist | Partial agonist | Partial Mu/delta agonist | |||

Morphiceptin | Partial agonist | Partial agonist | Mu agonist | |||

Nalbuphine | Partial agonist | Partial agonist | Partial agonist | Partial Mu/kappa agonist | ||

Naloxonazine | Partial agonist | Mu antagonist | ||||

Naloxone HCl | Opioid antagonist | |||||

Naloxone methiodide | Opioid antagonist | |||||

Naltrexone | Partial agonist | Opioid antagonist | ||||

Naltriben | Delta antagonist | |||||

Naltrindole | Delta antagonist | |||||

N-Benzylnaltrindole | Partial agonist | Partial agonist | Delta antagonist | |||

N-MPPP | Partial agonist | Partial agonist | Full agonist | Kappa agonist | ||

NNC 63-0532 | Partial agonist | Partial agonist | Partial agonist | Full agonist | ORL1 agonist | |

Nociceptin | Partial agonist | ORL1 agonist | ||||

Nor-Binaltorphimine | Kappa antagonist | |||||

(−)-Norcodeine | Partial agonist | Partial agonist | Partial agonist | Opioid antagonist | ||

Salvinorin A | Partial agonist | Full agonist | Kappa agonist | |||

SKF10047 | Partial agonist | Partial agonist | Opioid agonist/antagonist | |||

SNC 121 | Partial agonist | Partial agonist | Partial agonist | Delta agonist | ||

SNC 80 | Partial agonist | Partial agonist | Partial agonist | Partial agonist | Delta agonist | |

Syndyphalin SD-25 | Full agonist | Partial agonist | Partial agonist | Partial agonist | Mu agonist | |

TAPP | Partial agonist | Partial agonist | Partial agonist | Full agonist | Mu agonist | |

Tramadol | Partial agonist | Weak Mu agonist | ||||

(−)-U-50488 | Partial agonist | Partial agonist | Full agonist | Kappa partial agonist | ||

(+)-U-50488 | Full agonist | Kappa partial agonist | ||||

U-50,488H | Partial agonist | Partial agonist | Full agonist | Kappa agonist | ||

U-54494A | Partial agonist | Partial agonist | Partial agonist | Kappa agonist | ||

U-62066 | Partial agonist | Full agonist | Kappa agonist | |||

U-69593 | Partial agonist | Partial agonist | Full agonist | Kappa agonist |

The blank indicates that the ligand did not result in any noticeable DMR.

Morse * et al.*

Morse * et al.* *BMC Pharmacology and Toxicology* 2013 **14**:17 doi:10.1186/2050-6511-14-17