Table 2

Classification of opioid ligands based on their DMR agonist activity in the five distinct cell lines
Name HEK MOR DOR KOR SH-SY5Y Literature classification
β-Funaltrexamine off-target Partial agonist Partial agonist Partial agonist Mu antagonist
BNTX off-target off-target off-target off-target off-target Delta antagonist
Dynorphin A (2–13) off-target Partial agonist Partial agonist Kappa agonist
Etonitazenyl off-target Partial agonist Partial agonist Mu agonist
ICI 199,441 off-target Full agonist Partial agonist Full agonist Kappa agonist
Nociceptin (1–13) off-target Partial agonist Partial agonist ORL1 agonist
α-Neoendorphin Partial agonist Full agonist Full agonist Full agonist Kappa agonist
BRL-52537 Partial agonist Full agonist Kappa agonist
BUBUC Partial agonist Full agonist Partial agonist Partial agonist Delta agonist
DADLE Partial agonist Full agonist Partial agonist Full agonist Delta agonist
DALDA Partial agonist Full agonist Mu agonist
DAMGO Full agonist Partial agonist Partial agonist Full agonist Mu agonist
DAMME Full agonist Full agonist Partial agonist Full agonist Mu/Delta agonist
Deltorphin II Partial agonist Full agonist Delta agonist
DIPPA Partial agonist Partial agonist Full agonist Kappa antagonist
DPDPE Partial agonist Full agonist Partial agonist Full agonist Delta agonist
DSLET Full agonist Full agonist Partial agonist Full agonist Delta agonist
DTLET Full agonist Full agonist Partial agonist Full agonist Delta agonist
Dynorphin A (1–13) Full agonist Full agonist Full agonist Partial agonist Kappa agonist
Dynorphin A (1–8) Full agonist Full agonist Full agonist Full agonist Kappa agonist
Dynorphin B Partial agonist Full agonist Full agonist Full agonist Kappa agonist
Endomorphin-1 Partial agonist Partial agonist Partial agonist Mu agonist
Endomorphin-2 Partial agonist Partial agonist Partial agonist Full agonist Mu agonist
(Leu5)-Enkephalin Full agonist Full agonist Partial agonist Full agonist Mu/Delta agonist
(Met5)-Enkephalin Full agonist Full agonist Partial agonist Full agonist Mu/Delta agonist
GR 89696 Partial agonist Partial agonist Full agonist Full agonist Kappa agonist
ICI 204,448 Partial agonist Partial agonist Full agonist Full agonist Kappa agonist
Levallorphan Partial agonist Partial agonist Partial Mu/delta agonist
Morphiceptin Partial agonist Partial agonist Mu agonist
Nalbuphine Partial agonist Partial agonist Partial agonist Partial Mu/kappa agonist
Naloxonazine Partial agonist Mu antagonist
Naloxone HCl Opioid antagonist
Naloxone methiodide Opioid antagonist
Naltrexone Partial agonist Opioid antagonist
Naltriben Delta antagonist
Naltrindole Delta antagonist
N-Benzylnaltrindole Partial agonist Partial agonist Delta antagonist
N-MPPP Partial agonist Partial agonist Full agonist Kappa agonist
NNC 63-0532 Partial agonist Partial agonist Partial agonist Full agonist ORL1 agonist
Nociceptin Partial agonist ORL1 agonist
Nor-Binaltorphimine Kappa antagonist
(−)-Norcodeine Partial agonist Partial agonist Partial agonist Opioid antagonist
Salvinorin A Partial agonist Full agonist Kappa agonist
SKF10047 Partial agonist Partial agonist Opioid agonist/antagonist
SNC 121 Partial agonist Partial agonist Partial agonist Delta agonist
SNC 80 Partial agonist Partial agonist Partial agonist Partial agonist Delta agonist
Syndyphalin SD-25 Full agonist Partial agonist Partial agonist Partial agonist Mu agonist
TAPP Partial agonist Partial agonist Partial agonist Full agonist Mu agonist
Tramadol Partial agonist Weak Mu agonist
(−)-U-50488 Partial agonist Partial agonist Full agonist Kappa partial agonist
(+)-U-50488 Full agonist Kappa partial agonist
U-50,488H Partial agonist Partial agonist Full agonist Kappa agonist
U-54494A Partial agonist Partial agonist Partial agonist Kappa agonist
U-62066 Partial agonist Full agonist Kappa agonist
U-69593 Partial agonist Partial agonist Full agonist Kappa agonist

The blank indicates that the ligand did not result in any noticeable DMR.

Morse et al.

Morse et al. BMC Pharmacology and Toxicology 2013 14:17   doi:10.1186/2050-6511-14-17

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