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Open Access Research article

Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family

Megan Morse1, Haiyan Sun2, Elizabeth Tran2, Robert Levenson1* and Ye Fang2*

Author Affiliations

1 Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA

2 Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, NY, USA

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BMC Pharmacology and Toxicology 2013, 14:17  doi:10.1186/2050-6511-14-17

Published: 12 March 2013

Additional files

Additional file 1: Figure S1:

DMR characteristics of a subset of ligands in parental HEK293 cells, Figure S2: A colored heat map based on the DMR of opioid ligands in five different cell lines, Figure S3: A colored heat map based on the selectivity of opioid ligands to block the DMR of control agonists in respective cell lines, Table S1: Opioid ligands and their affinity binding to the MOR, Table S2: Opioid ligands and their affinity binding to the DOR, and Table S3: Opioid ligands and their affinity binding to the KOR.

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