Table 1

Correlation between imaging and sequence-based methylcytosine levels
3D-qDMI MethyLight
AZA concentration Normalized MeC intensity Normalized Alu PMR value Normalized Sat2 PMR value Normalized Satα PMR value
No Drug 1.00 1.00 1.00 1.00
0.5 μM 0.72 0.92 0.86 0.37
1 μM 0.34 0.49 0.65 0.20
2.5 μM 0.26 0.51 0.69 0.42
5 μM 0.20 0.31 0.31 0.15
10 μM 0.14 0.17 0.45 0.22
20 μM 0.13 0.61 0.58 0.88
Correlation coefficient R* 0.96 0.89 0.86

* Correlation coefficient R was calculated between the normalized MeC intensities measured by 3D-qDMI and normalized PMR values of the three classes of repetitive elements obtained by MethyLight, excluding the values for 20 μM of AZA.

Gertych et al.

Gertych et al. BMC Pharmacology and Toxicology 2013 14:11   doi:10.1186/2050-6511-14-11

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