Nuclear codistribution of H3K9me3 and global DNA. Heterchromatin-associated H3K9me3 (red) significantly colocalizes with DAPI-intense areas (blue) in untreated and AZA-treated Huh-7 cells. The scatter plots show that the signal in both channels gradually decreases with increasing drug concentration. The relatively stable inclination of the colocalization graph indicates that both signals regress proportionally, which could be interpreted as a tight correlation between heterochromatin and DAPI-intense regions.
Gertych et al. BMC Pharmacology and Toxicology 2013 14:11 doi:10.1186/2050-6511-14-11