Cell population homogeneity measurement. Left diagram (different drugs): normalized proportions of the different cell populations (n ≈ 300 is the number of cells analyzed for each category); untreated control cells show a high fraction (≥ 95%) of pooled similar cells (KL < 4.5); this is true also for the majority of drug concentrations with both cell types (similarity on average ≥ 90%); the lowest homogeneity values being still relatively high at 82% for DU145/0.5 μM AZA and 79% for DU145/10 μM AZA. For simplification purposes, the rest of the cells were summarized as dissimilar cells (KL ≥ 4.5) in this display.
Gertych et al. BMC Pharmacology and Toxicology 2013 14:11 doi:10.1186/2050-6511-14-11