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This article is part of the supplement: 18th Scientific Symposium of the Austrian Pharmacological Society (APHAR)

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Use of ACE inhibitors in Serbia in 2010

Boris Milijašević*, Zdenko Tomić, Ana Sabo, Aleksandar Rašković and Momir Mikov

Author Affiliations

Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia

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BMC Pharmacology and Toxicology 2012, 13(Suppl 1):A3  doi:10.1186/2050-6511-13-S1-A3

The electronic version of this article is the complete one and can be found online at:

Published:17 September 2012

© 2012 Milijašević et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cardiovascular diseases are the most frequent cause of morbidity and mortality in many countries. That explains why medications for the treatment of cardiovascular diseases are the group of drugs with the largest consumption, and ACE inhibitors take a large part in this consumption. The aim of this study was to analyze the consumption of ACE inhibitors in Serbia in 2010 compared with Norway, a country with a developed pharmacotherapeutic practice.


The data about the use of ACE inhibitors in Serbia were taken from the Agency for Drugs and Medical Devices of the Serbia. The data about drug consumption in Norway were taken from the official website of the Norwegian Institute of Public Health.


In Serbia, the use of drugs of first choice in the treatment of hypertension was very uneven, where the consumption of ACE inhibitors was dominant. Opposed to this condition, the consumption of the first choice antihypertensive drugs was very balanced in Norway. Total consumption of ACE inhibitors in Serbia in 2010 year was 190.4 defined daily doses per 1000 inhabitants per day (DID) and total consumption of ACE inhibitors in Norway in 2010 year was 51.7 DID. During the analyzed year the largest use of plain ACE inhibitors in Serbia was for enalapril (81.0 DID), ramipril (34.2 DID), fosinopril (24.5 DID) and cilazapril (13.1 DID) and in Norway was ramipril (27.3 DID), enalapril (11.1 DID) and lisinopril (6.2 DID). In Serbia a significant part of the consumption of ACE inhibitors consisted of more expensive drugs such as fosinopril, cilazapril and quinapril, whereas these have not been used at all in Norway during that period.


In Serbia in the year 2010, ACE inhibitors and their fixed combination with diuretics are the most frequently used drugs within the group of drugs which is used for cardiovascular diseases treatment. The amount and structure of the utilized ACE inhibitors in Serbia is different in a lot of ways from the amount and structure of the utilized ACE inhibitors in Norway. Pharmacoeconomic analyses also show that large financial resources would be saved if the structure of the utilized ACE inhibitors in Serbia were more similar to the one in Norway.


This research was financially supported by the Ministry of Science, Republic of Serbia, project no. 41012.