Table 3

Summary of studies that have examined hepatotoxicity rates in patients with paracetamol overdose
Author Year Location n Hepatotoxicity % Survival % Paracetamol Dose
Proudfoot [22] 1970 Edinburgh, U.K. 41 39% 97.6% 39% > 15 g
Schiodt [14] 1997 Texas, U.S. 71 32% 93% Median = 17.6 g 93% > 4 g
Hawton [17] 1996 Oxford, U.K. 80 31% NA 69% > 12.5 g
Gyamlani [15] 2001 New York, USA 93 16% 98% NA
James [16] 2008 USA 157 15% (1.3% ALF) 100% Mean 18 g
Ayonrinde [5] 2005 Australia 188 14% 100% Median = 12 g
Mohd-Zain [9] 2006 Penang, Malaysia 165 7.3% 100% 38% > 10 g
Current study 2011 Kuala Lumpur , Malaysia 1024 7.5% 100% Median 10 g (54.3% > 10 g)
Chan [10] 1993 Hong Kong 104 6% 100% Median 5 g 6.7% > 10 g
Mills [19] 2008 Jamaica 49 2% 100% Range 2–30 g
Schmidt [18] 2002 Copenhagen, Denmark 737 No data on hepatotoxicity (0.9% ALF) 99.9% Median 25 g

Marzilawati et al.

Marzilawati et al. BMC Pharmacology and Toxicology 2012 13:8   doi:10.1186/2050-6511-13-8

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