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Open Access Highly Accessed Research article

Pulling chromatin apart: Unstacking or Unwrapping?

Jean Marc Victor1, Jordanka Zlatanova2, Maria Barbi1 and Julien Mozziconacci1*

Author Affiliations

1 , Laboratory for Theoretical Physics of Condensed Matter, UPMC, 75005 Paris, France

2 Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA

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BMC Biophysics 2012, 5:21  doi:10.1186/2046-1682-5-21

Published: 27 November 2012

Abstract

Background

Understanding the mechanical properties of chromatin is an essential step towards deciphering the physical rules of gene regulation. In the past ten years, many single molecule experiments have been carried out, and high resolution measurements of the chromatin fiber stiffness are now available. Simulations have been used in order to link those measurements with structural cues, but so far no clear agreement among different groups has been reached.

Results

We revisit here some of the most precise experimental results obtained with carefully reconstituted fibers.

Conclusions

We show that the mechanical properties of the chromatin fiber can be quantitatively accounted for by the stiffness of the DNA molecule and the 3D structure of the chromatin fiber.