Disk-shaped cells can support gradients along the source/sink axis.A) Schematic of a disk-shaped cell with distance r2 = 1 μm from the center to the poles and equatorial radius r1 between 0.2 and 1.25 μm, with oppositely localized kinase and phosphatase. B) 2D Mathematical modeling of the distribution of [R ∼ P] in an ellipse geometry. C) [R ∼ P] line scan through the cell middle showing volume-weighted average density along cell length (along the dashed line in A) for varying ellipticity.
Tropini et al. BMC Biophysics 2012 5:17 doi:10.1186/2046-1682-5-17