Cell bending does not significantly affect the R ∼ P gradient even for small cellular radius of curvature.A) Schematic of a bent cell with radius of curvature Rcwith oppositely localized kinase and phosphatase. B) 3D mathematical modeling of the distribution of [R ∼ P] in a bent cell with radius of curvature Rc = 1 μm. C) [R ∼ P] line scan through the cell middle showing volume-weighted average density along cell length (along the dashed line in A) for different Rc.
Tropini et al. BMC Biophysics 2012 5:17 doi:10.1186/2046-1682-5-17