Crystal structure of EhCaBP1. The sequence on the top shown with the N and C-terminal domains. In the structure only the N-terminal domain was traced since the C-terminal domain is disordered. A) The three molecules of the N-terminal domain come together to form a trimer. B) Each monomer is an extended structure with two EF hand motifs separated by a long helix. This calcium bound structure was reported earlier by Kumar et al., 2007. C-E) The heavy atom complex structures. C) Sr2+ complex, D) Ba2+ complex and E) Pb2+ complex of EhCaBP1 have overall similar structures to the native Ca2+ bound structure.
Kumar et al. BMC Biophysics 2012 5:15 doi:10.1186/2046-1682-5-15