Table 6

List of top ranked residues and the most persistent edges
Rank Position Number of edges (at λ = 38) Most persistent pair position (edges at penalty λ = 140)
1 A1173.32 41 G902.57, E247 IC3, F2937.40, K2967.43
2 A2726.55 30 L72IC1, G1143.29, S176EC2, Y178EC2
3 E1133.28 29 M441.39, L72IC1, W1263.41, Q237IC3, F2937.40
4 H2115.46 29 F912.58, C140 IC2, F148 IC2
5 A2927.39 28 Y29EC (N-terminus)
6 S186EC2 27 K67IC1, Q244IC3, P2917.38
7 E1223.37 26 I481.43, G902.57, E196EC3, M2075.42, A2696.52, F2937.40, C316IC (C-terminus)
8 G902.57 23 A1173.32, G1203.35, E1223.37, M2075.42, Q237IC3, A2696.52, F2937.40
9 G1143.29 22 S176EC2, A2726.55, Y178EC2
10 M2075.42 22 G902.57, E1223.37, C316IC (C-terminus)

Residues in bold are part of the RT binding pocket extracted from the rhodopsin structure (PDB ID: 1U19). The Ballesteros-Weinstein numbering (superscript) is given for comparison with other GPCRs. Only long-range edges are reported i.e. the edges formed with neighboring residues (8 amino acids on either side) are filtered out.

Moitra et al.

Moitra et al. BMC Biophysics 2012 5:13   doi:10.1186/2046-1682-5-13

Open Data