A schematic view of the spindle assembly checkpoint and anaphase. A: Before all chromosomes are all attached, the mitotic checkpoint complex inhibits the Cdc20 molecules binding with APC/C to prevent premature separation of sister chromatids. This signal ubiquitylates Cdc20. B: When all chromosomes are properly attached, the inhibiting signal is shut down. C and D: Activation of APC/C triggers the separation of the chromatids and ultimately the anaphase.
Dao Duc and Holcman BMC Biophysics 2012 5:1 doi:10.1186/2046-1682-5-1