Relationship between cluster size and distributions of cluster shapes. (a) shows a heatmap of the normalized empirical frequency distribution for integrin cluster shape, characterized by eccentricity, for different ranges of integrin cluster sizes. The cluster sizes separated into columns in all panes of (a) are: 0.1-0.2 μm2, 0.2-0.3 μm2, 0.3-0.4 μm2, 0.4-0.6 μm2, 0.6-1 μm2. (b) shows the fitted beta probability distributions for integrin clusters of different sizes in cells adhering to 10 μg/mL Fg, and (c) shows the corresponding estimated beta distribution parameters along with 95% confidence intervals on the parameter estimates.
Welf et al. BMC Biophysics 2011 4:15 doi:10.1186/2046-1682-4-15