Table 2

Similarities between Hepatitis C and HIV

HCV

HIV

Envelope and Core Ags

+

+

Glycosylated envelope protein

+

+

Envelope is neut. target, but hypervariable

+

+

Chronic viremia

+

+

Escape mutation

+

+

Geographical genetic variation

+

+

PD-1 Upregulated

+

+

High titer neutralizing Ab protects

+

+

Strong cell responses against multiple epitopes necessary for control of viremia

+

+

CD4+ cells needed to sustain CD8+ T cells

+

+

Tcm cells needed for long-term control

+

+

Plotkin Journal of the International AIDS Society 2009 12:2   doi:10.1186/1758-2652-12-2