Open Access Research article

Evolutionary and sequence-based relationships in bacterial AdoMet-dependent non-coding RNA methyltransferases

Jeanneth Mosquera-Rendón12, Sonia Cárdenas-Brito1, Juan D Pineda3, Mauricio Corredor12 and Alfonso Benítez-Páez1*

Author Affiliations

1 Bioinformatics Analysis Group – GABi, Centro de Investigación y Desarrollo en Biotecnología – CIDBIO, 111221 Bogotá, D.C, Colombia

2 GEBIOMIC Group, Faculty of Life Sciences, Universidad de Antioquia, Medellín, Colombia

3 APOLO Computing Center. EAFIT, Medellín, Colombia

For all author emails, please log on.

BMC Research Notes 2014, 7:440  doi:10.1186/1756-0500-7-440

Published: 10 July 2014

Additional files

Additional file 1: Figure S1:

The Cumulative Substitution Rate plots for genes rlmN and rsmG. A comparative analysis done with the genes and pathogens for the distribution of the synonymous and non-synonymous substitutions in genes rlmN and rsmG is shown. Those genes are well known to be associated to antibiotic resistance. Critical sites for the protein function are highlighted in gray. The correlation between the high accumulation of the non-synonymous substitutions and hotspots for the functional inactivation of RsmG are more clearly inferred.

Format: PDF Size: 174KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2: Figure S2:

Close view for Cumulative Substitution Rate in rsmG. Two plots showing the distribution of the synonymous and non-synonymous substitutions at amino acid sequence level in rsmG genes from H. pylori and P. aeruginosa. Red lines show cumulative synonymous substitutions and green lines show non-synonymous substitutions. Hotspots for protein inactivation (gray shaded amino acid positions) were compiled from [27,85].

Format: PDF Size: 70KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data