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Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder

Xiaohui Xu1*, Gerome Breen1, Lucy Luo2, Bo Sun2, Chih-Ken Chen345, Ursula M Paredes1, Yu-Shu Huang45, Yu-Yu Wu45 and Philip Asherson1

Author affiliations

1 MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London, UK

2 School of Medicine, King’s College London, London, UK

3 Department of Psychiatry, Chang Gung Memorial Hospital, Taoyuan, Taiwan

4 Chang Gung University School of Medicine, Taoyuan, Taiwan

5 Division of Mental Health & Drug Abuse Research, National Health Research Institutes, Taoyuan, Taiwan

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Citation and License

BMC Research Notes 2013, 6:29  doi:10.1186/1756-0500-6-29

Published: 26 January 2013

Abstract

Background

Genome-wide association studies (GWAS) have been conducted on many psychiatric disorders. Evidence from large GWAS indicates that the single nucleotide polymorphism (SNP) rs1344706 in the zinc-finger protein 804A gene (ZNF804A) is associated with psychotic disorders including bipolar disorder and schizophrenia. One study also found significant association between rs1344706 and the executive control network of attention. In this study we examine the role of the rs1344706 polymorphism that previously showed association with BD and is known to alter expression of the gene in two clinical family-based ADHD samples from the UK and Taiwan.

Findings

To investigate the association between rs1344706 and ADHD, two family samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212) were genotyped using TaqMan SNP genotyping assays and analysed using within-family transmission disequilibrium test. No significant associations were found between rs1344706 polymorphism and ADHD in either of the samples from Taiwan (P = 0.91) and UK (P = 0.41). Even combining the two datasets together the A allele of rs1344706 SNP was still not significantly over-transmitted to affected probands (P = 0.50). Furthermore, there was no evidence of association with the specific symptoms subgroups of inattention or hyperactivity-impulsivity.

Conclusions

In this study we used family-based ADHD data in the UK and Taiwanese population to test for an association between rs1344706 SNP in the ZNF804A gene and ADHD. Results showed no significant association of rs1344706 with ADHD in UK and Taiwanese samples.

Keywords:
Attention deficit hyperactivity disorder; ZNF804A; Single nucleotide polymorphism; Association study; Bipolar disorder