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Open Access Highly Accessed Technical Note

miRviewer: a multispecies microRNA homologous viewer

Adam Kiezun1, Shay Artzi2, Shira Modai3, Naama Volk3, Ofer Isakov3 and Noam Shomron3*

Author Affiliations

1 Division of Genetics, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston MA 02115, USA

2 Program Analysis and Transformation Group, IBM, Watson Research Center, Hawthorne, NY 10532, USA

3 Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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BMC Research Notes 2012, 5:92  doi:10.1186/1756-0500-5-92

Published: 13 February 2012

Abstract

Background

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via binding to the 3' ends of mRNAs. MiRNAs have been associated with many cellular events ascertaining their central role in gene regulation. In order to better understand miRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes.

Findings

The miRviewer web-server, presented here, encompasses all known miRNAs of currently fully annotated animal genomes in a visual 'birds-eye' view representation. miRviewer provides a graphical outlook of the current miRNA world together with sequence alignments and secondary structures of each miRNA. As a test case we experimentally examined the expression of several miRNAs in various animals.

Conclusions

miRviewer completes the homologous miRNA space with hundreds of unreported miRNAs and is available at: http://people.csail.mit.edu/akiezun/miRviewer webcite