miRviewer: a multispecies microRNA homologous viewer
- Equal contributors
1 Division of Genetics, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston MA 02115, USA
2 Program Analysis and Transformation Group, IBM, Watson Research Center, Hawthorne, NY 10532, USA
3 Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
BMC Research Notes 2012, 5:92 doi:10.1186/1756-0500-5-92Published: 13 February 2012
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via binding to the 3' ends of mRNAs. MiRNAs have been associated with many cellular events ascertaining their central role in gene regulation. In order to better understand miRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes.
The miRviewer web-server, presented here, encompasses all known miRNAs of currently fully annotated animal genomes in a visual 'birds-eye' view representation. miRviewer provides a graphical outlook of the current miRNA world together with sequence alignments and secondary structures of each miRNA. As a test case we experimentally examined the expression of several miRNAs in various animals.