Email updates

Keep up to date with the latest news and content from BMC Research Notes and BioMed Central.

Open Access Short Report

Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs

Michail Papamichail12*, Michail Digalakis2, Prigouris Panagiotis3, Odysseas Paisios2, Soyltana Loti2 and Theodoros Sergentanis4

Author Affiliations

1 Department of HBP Surgery, Freeman Hospital, Freeman Road, Newcastle, S57AU, UK

2 General Hospital, Asklipio Voulas, Athens, Greece

3 General Hospital Evangelismos, Athens, Greece

4 Medical School, University of Athens, Athens, Greece

For all author emails, please log on.

BMC Research Notes 2012, 5:463  doi:10.1186/1756-0500-5-463

Published: 28 August 2012

Abstract

Background

Interposition of a reversed jejunal loop in short bowel sydrome has previously been investigated in human along with animal models and seemed able to facilitate intestinal adaptation. However, it is unclear if growth hormone and insulin, well known for their implication in short bowel pathophysiology, intervene on this effect.

Findings

Porcine models were randomly allocated to two cohorts: (1) short bowel (SB) group (nā€‰=ā€‰8) and (2) short bowel reverse jejunal segment (SB-RS) group (nā€‰=ā€‰8). Amongst other parameters serum growth hormone and insulin were measured at baseline, as well as on postoperative day 30 and 60.

Conclusion

Both endogenous hormones failed to demonstrate significant difference in respect to potential direct effect to mechanisms of enhanced intestinal adaptation in reversed group

Keywords:
Growth hormone; Insulin; Short bowel syndrome; Reversed jejunal segment