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Open Access Short Report

Statin cost effectiveness in primary prevention: A systematic review of the recent cost-effectiveness literature in the United States

Aaron P Mitchell1* and Ross J Simpson2

Author affiliations

1 Duke University Medical Center, Medical Residency Office Rm 8254DN, 2301 Erwin Rd, Durham, NC, 27710, USA

2 Department of Cardiology, UNC-Chapel Hill School of Medicine, 101 Manning Drive, Chapel Hill, NC, 27514, USA

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Citation and License

BMC Research Notes 2012, 5:373  doi:10.1186/1756-0500-5-373

Published: 24 July 2012

Abstract

Background

The literature on the cost-effectiveness of statin drugs in primary prevention of coronary heart disease is complex. The objective of this study is to compare the disparate results of recent cost-effectiveness analyses of statins.

Findings

We conducted a systematic review of the literature on statin cost-effectiveness. The four studies that met inclusion criteria reported varying conclusions about the cost-effectiveness of statin treatment, without a clear consensus as to whether statins are cost-effective for primary prevention. However, after accounting for each study’s assumptions about statin costs, we found substantial agreement among the studies. Studies that assumed statins to be more expensive found them to be less cost-effective, and vice-versa. Furthermore, treatment of low-risk groups became cost-effective as statins became less expensive.

Conclusions

Drug price is the primary determinant of statin cost-effectiveness within a given risk group. As more statin drugs become generic, patients at low risk for coronary disease may be treated cost-effectively. Though many factors must be weighed in any medical decision, from a cost-effectiveness perspective, statins may now be considered an appropriate therapy for many patients at low risk for heart disease.

Keywords:
Statin; Cost-effectiveness; Primary prevention; Drug cost; Systematic review