Table 1

List of selected novel RASSF1C target genes identified in NSCLC (NCI-H1299) cells
Cell Cycle and Growth
  Gene Gene Description Fold change
BHLHB2 basic helix-loop-helix domain containing, class B, 2 3.06
CAV1 caveolin 1, caveolae protien, 22 kDa 2.9
CLU clusterin 3.66
CREG1 cellular repressor of E1A-stimulated genes 1 2.06
EGFR epidermal growth factor receptor 2.52
EGR1 early growth responds 1 2.35
FGF2 fibroblast growth factor 2 (basic) 2.19
GDF15 growth differentiation factor 15 2.83
HBEGF herapin-binding EGF-like growth factor 2
KLF4 Kruppel-like factor 4 (gut) 2.36
LIF leukemia inhibitory factor (cholinergic differentiation factor) 2.14
MDK midkine (neurite growth-promoting factor 2) 2.51
PLK2 polo-like kinase 2 (Drosophila) 5.79
DAL-1 Differentially expressed in adenocarcinoma of the lung-1 (DAL-1) -3.32
Cell proliferation
  Gene Gene Description Fold change
ABCB ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 8.07
CAV2 caveolin 2 2.05
COL4A1 collagen, type IV, alpha 1 2.96
COL4A2 collagen, type IV, alpha 2 2.92
CRABP2 cellular retinoic acid binding protein 2 2.18
CRIP2 cysteine-rich protein 2 2.23
EFNB2 ephrin-B2 −2.78
GSN gelsolin (amyloidosis, Finnish type) 2.51
KISS1 KiSS metastasis-suppressor −2.97
PIWIL1 piwi-like 1 (Drosophila) 6.87
PLK2 polo-like kinase 2 (Drosophila) 5.79
RASGEF1A RasGEF domain family, member 1A 3
Cell death
  Gene Gene Description Fold change
AMIGO2 adhesion molecule with lg-like domain 2 4.16
CARD8 caspase recruitment domain family, member 8 −2.2
CASP4 caspase 4 −1.6
HBEGF heparin-binding EGF-like growth factor 2
DKK1 dickkopf homolog 1 (Xenopus laevis) 2.62
KLF4 Kruppel-like factor 4 (gut) 2.36
KLF10 Kruppel-like factor 10 2.65

Reeves et al.

Reeves et al. BMC Research Notes 2012 5:239   doi:10.1186/1756-0500-5-239

Open Data