Table 2

Functional enrichment in the regulatory hierarchy
Function z-score p-value
Layer-1 Biogenesis of cellular components −2.26 0.02
Cell cycle and DNA processing −2.29 0.01
Cell rescue, defense and virulence −4.16 1.58*10-5
Cell type differentiation −3.28 5.18*10-4
Cellular communication/signal transduction mechanism −2.1 0.01
Cellular transport, transport facilities and transport routes 6.56 2.74*10-11
Interaction with the environment −3.93 4.19*10-5
Metabolism 4.67 1.51*10-6
Protein with binding function or cofactor requirement −2.8 2.56*10-3
Regulation of metabolism and protein function 6.1 5.47*10-10
Layer-2 Cell type differentiation 1.95 0.02
Cellular transport, transport facilities and transport routes −2.18 0.01
Interaction with the environment 2.28 0.01
Layer-3 Metabolism −1.95 0.02
Regulation of metabolism and protein function −1.88 0.03
Cell type differentiation −2.18 0.01
Interaction with the environment −2.62 4.43*10-3
Regulation of metabolism and protein function −1.81 0.03

This table shows all significantly over-represented or under-represented functional categories for cooperative TFs in regulatory hierarchy. Negative z-scores mean under-representation, positive z-scores mean over-representation.

Aguilar and Oliva

Aguilar and Oliva BMC Research Notes 2012 5:227   doi:10.1186/1756-0500-5-227

Open Data