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Open Access Short Report

Visceral leishmaniasis in 26 HIV-negative adults

Hazar Lahlou1*, Ahmed B Filali1, Meryem Alami1, Moncef Amrani1, Rhizlane Berrady2, Samira Rabhi2 and Wafaa Bono2

Author Affiliations

1 Laboratory of Hematology, University Hospital of Fez, Atlas, Fez, Morocco

2 Internal Medicine Department, University Hospital of Fez, Atlas, Fez, Morocco

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BMC Research Notes 2011, 4:389  doi:10.1186/1756-0500-4-389

Published: 8 October 2011

Abstract

Background

Visceral leishmaniasis is a notifiable parasitic disease that had increased in incidence in our region on the past few years. It is common in children. In adults, it occurs more on a background of immunodeficiency, and frequently with incomplete clinical manifestations, making the diagnosis complicated.

Findings

The aim of our study is to reveal different features of visceral leishmaniasis in adults, through the analysis of its epidemiological, clinical and biological parameters, in a group of 26 patients. No one was infected with HIV or under immunosuppressive therapy Clinical presentation was generally conservative, but there was few differences in adults compared to children, concerning both the clinical symptoms and the laboratory parameters. Diagnosis was provided by direct examination of bone marrow smears in 24 cases (sensitivity 92%), and anti-leishmanial serology in the others.

Conclusion

We should think to the diagnosis of VL even if the patient is not known immunocompromised, and even if the clinical is incomplete, to avoid a delay of care which can lead to serious complications.

Keywords:
visceral leishmaniasis; HIV-negative adults; bone marrow aspirate; immunofluorescent antibody test